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    Chemistry

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    Also known as: Bupivacaine hcl, 18010-40-7, 14252-80-3, Carbostesin, Vivacaine, Sensorcaine
    Molecular Formula
    C18H29ClN2O
    Molecular Weight
    324.9  g/mol
    InChI Key
    SIEYLFHKZGLBNX-UHFFFAOYSA-N
    FDA UNII
    AKA908P8J1
    Bupivacaine Hydrochloride
    A widely used local anesthetic agent.
    1 2D Structure

    Bupivacaine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H
    2.1.3 InChI Key
    SIEYLFHKZGLBNX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    AKA908P8J1
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide

    2. Bupivacain Janapharm

    3. Bupivacain Rpr

    4. Bupivacain-rpr

    5. Bupivacaina Braun

    6. Bupivacaine

    7. Bupivacaine Anhydrous

    8. Bupivacaine Carbonate

    9. Bupivacaine Monohydrochloride, Monohydrate

    10. Buvacaina

    11. Carbostesin

    12. Dolanaest

    13. Marcain

    14. Marcaine

    15. Sensorcaine

    16. Svedocain Sin Vasoconstr

    2.3.2 Depositor-Supplied Synonyms

    1. Bupivacaine Hcl

    2. 18010-40-7

    3. 14252-80-3

    4. Carbostesin

    5. Vivacaine

    6. Sensorcaine

    7. Bupivacaine (hydrochloride)

    8. 1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

    9. Marcain

    10. Ah-2250

    11. Bupivacaine Hydrochloride Anhydrous

    12. Lac-43

    13. Nsc-758631

    14. 1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride

    15. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-, Monohydrochloride

    16. Win 11,318

    17. Aka908p8j1

    18. Chebi:31322

    19. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide Monohydrochloride

    20. Bloqueina

    21. Xaracoll

    22. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-, Hydrochloride (1:1)

    23. (s)-bupivacaine Hydrochloride

    24. Bicain

    25. Marcaine Spinal

    26. Smr000058218

    27. (+-)-bupivacaine Hydrochloride

    28. Bupivacaine Hydrochloride [jan]

    29. Mnarcaine Hydrochloride

    30. Einecs 241-917-8

    31. Bupivacaine Hydrochloride Kit

    32. Unii-aka908p8j1

    33. Lac 43

    34. Sr-05000001874

    35. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide

    36. Levobupivacaine Hydrochloride (anhydrous)

    37. 2',6'-pipecoloxylidide, 1-butyl-, Hydrochloride

    38. Sky 0302

    39. Prestwick_894

    40. 2',6'-pipecoloxylidide, 1-butyl-, Monohydrochloride

    41. Ah 2250

    42. Marcaine Hydrochloride Preservation Free

    43. Bupivacain Hydrochloride

    44. Bupivacaine Hydrochloride Preservation Free

    45. Bupivacaini Hydrochloridum

    46. Bupivacaine Hydrochloride Rs

    47. Bupivacaine Monohydrochloride

    48. Win 11318 Hcl

    49. Schembl34374

    50. Mls001361336

    51. Mls002154259

    52. Spectrum1503818

    53. Bupivacaine-[d9] Hydrochloride

    54. Chembl1200396

    55. Dtxsid0030877

    56. Chebi:77441

    57. Hy-b0405a

    58. Bupivacaine Hydrochloride(marcain)

    59. Hms1568n12

    60. Hms1922i12

    61. Pharmakon1600-01503818

    62. Bupivacaine Hydrochloride (marcain)

    63. Act04725

    64. Bcp22697

    65. Bcp22708

    66. Bupivacaine Hydrochloride (anhydrous)

    67. Ccg-39367

    68. Mfcd00078956

    69. Nsc119660

    70. Nsc758631

    71. S2454

    72. Bupivacaine Hydrochloride [mi]

    73. Akos015889322

    74. Bcp9000461

    75. Fd-0235

    76. Nsc 758631

    77. Nsc-119660

    78. Ncgc00095072-01

    79. Ncgc00095072-02

    80. Anhydrous Bupivacaine Hydrochloride

    81. Bupivacaine Hydrochloride [who-dd]

    82. Bupivacaine Hydrochloride, Anhydrous

    83. B3925

    84. Ft-0607564

    85. Ft-0623287

    86. Ft-0658830

    87. Ft-0663897

    88. Ft-0663899

    89. Sw197015-3

    90. 52b803

    91. Bupivacaine Hydrochloride [usp Impurity]

    92. J-011502

    93. Q-100158

    94. Sr-05000001874-3

    95. Q27888209

    96. 1-butyl-2-piperidylformo-2',6'-xylidide Hydrochloride

    97. 2-piperidinecarboxamide,6-dimethylphenyl)-, Hydrochloride

    98. 1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium Chloride

    99. (+/-)-1-butyl-2',6'-pipecoloxylidide Monohydrochloride

    100. Rac-1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium Chloride

    101. Rac-1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

    102. 15233-43-9

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 324.9 g/mol
    Molecular Formula C18H29ClN2O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass324.1968412 g/mol
    Monoisotopic Mass324.1968412 g/mol
    Topological Polar Surface Area32.3 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity321
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameBupivacaine hydrochloride
    PubMed HealthBupivacaine/Epinephrine (Injection)
    Drug ClassesAnesthetic, Amino Amide Combination, Anesthetic, Local
    Drug LabelSensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
    Active IngredientBupivacaine hydrochloride
    Dosage FormInjectable
    Routeinjection; Spinal; Injection
    Strength0.5%; 0.75%; 0.25%
    Market StatusPrescription
    CompanySagent Agila; Hospira

    2 of 6  
    Drug NameMarcaine
    PubMed HealthBupivacaine (Injection)
    Drug ClassesAnesthetic, Local
    Drug LabelMarcaineBupivacaine Hydrochloride Injection, USPMarcaineWith Epinephrine 1:200,000 (as bitartrate)Bupivacaine Hydrochloride and Epinephrine Injection, USP Rx onlyBupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylpheny...
    Active IngredientBupivacaine hydrochloride
    Dosage FormInjectable
    RouteSpinal
    Strength0.75%
    Market StatusPrescription
    CompanyHospira

    3 of 6  
    Drug NameSensorcaine
    Drug LabelSensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
    Active IngredientBupivacaine hydrochloride; epinephrine bitartrate
    Dosage FormInjectable
    RouteSpinal; Injection
    Strength0.5%; 0.0091mg/ml; 0.75%; 0.25%
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    4 of 6  
    Drug NameBupivacaine hydrochloride
    PubMed HealthBupivacaine/Epinephrine (Injection)
    Drug ClassesAnesthetic, Amino Amide Combination, Anesthetic, Local
    Drug LabelSensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
    Active IngredientBupivacaine hydrochloride
    Dosage FormInjectable
    Routeinjection; Spinal; Injection
    Strength0.5%; 0.75%; 0.25%
    Market StatusPrescription
    CompanySagent Agila; Hospira

    5 of 6  
    Drug NameMarcaine
    PubMed HealthBupivacaine (Injection)
    Drug ClassesAnesthetic, Local
    Drug LabelMarcaineBupivacaine Hydrochloride Injection, USPMarcaineWith Epinephrine 1:200,000 (as bitartrate)Bupivacaine Hydrochloride and Epinephrine Injection, USP Rx onlyBupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylpheny...
    Active IngredientBupivacaine hydrochloride
    Dosage FormInjectable
    RouteSpinal
    Strength0.75%
    Market StatusPrescription
    CompanyHospira

    6 of 6  
    Drug NameSensorcaine
    Drug LabelSensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
    Active IngredientBupivacaine hydrochloride; epinephrine bitartrate
    Dosage FormInjectable
    RouteSpinal; Injection
    Strength0.5%; 0.0091mg/ml; 0.75%; 0.25%
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Amides [CS]; Local Anesthesia [PE]; Amide Local Anesthetic [EPC]

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A30,A.I.E"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741199400,"product":"BUPIVACAINE HYDROCHLORIDE MONOHYDRATE API (SAMPLE ,FOC) BUPIVACAINE HYDROCHLORIDE MONOHYDRATE API (SAMPLE ,FOC)","address":"ASURVEY NO.225, SAMPANBOLE VILLAGE","city":"","supplier":"CAMBREX KARLSKOGA AB","supplierCountry":"SWEDEN","foreign_port":"GOTHENBURG","customer":"ALPHAMED FORMULATIONS PRIVATE LTD","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"3966.4","totalValueFC":"401.8","currency":"SEK","unitRateINR":"348052.3","date":"06-Mar-2025","totalValueINR":"34805.23","totalValueInUsd":"401.8","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"8734540","productDescription":"API","marketType":"REGULATED MARKET","country":"SWEDEN","selfForZScoreResived":"Pharma Grade","supplierPort":"GOTHENBURG","supplierAddress":"SE-691 85 KARLSKOGA SWEDEN SDNF SDNF Sweden","customerAddress":"ASURVEY NO.225, SAMPANBOLE VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1748025000,"product":"LEVOBUPIVACAINE HCL (THIRD COUNTRY EXPORT UNDERPARA 2.46 OFEXIM POLICY 2015-20)LEVOBUPIVACAINE HCL (THIRD COUNTRY EXPORT UNDERPARA 2.46 OF","address":"112,, MARINE CHAMBERS,","city":"MUMBAI. MAHARASHTRA","supplier":"SHANDONG CHENGHUI SHUANGDA PHARMACE","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ALCON BIOSCIENCES PRIVATE LTD","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"900","totalValueFC":"3650.7","currency":"USD","unitRateINR":"77760","date":"24-May-2025","totalValueINR":"311040","totalValueInUsd":"3650.7","indian_port":"Bombay Air","hs_no":"29242990","bill_no":"2258897","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"UTICAL CO., LTD. ECONOMIC DEVELOPME NT ZONE,PINGYUAN COUNTY,DEZHOU,SHAN DONG,CHINA CHINA","customerAddress":"112,, MARINE CHAMBERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1750098600,"product":"BUPIVACAINE HYDROCHLORIDE CODE.NO.75630 NDC: 52932-0729 BATCH NO: 91BUPIVACAINE HYDROCHLORIDE CODE.NO.75630 NDC: 52932-0729 BATC","address":"CLARIS CORPORATE HEAD QUARTERS,","city":"ELLISBRIDGE,AHMEDABD,GUJARAT,INDIA","supplier":"MOEHS CATALANA SL","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"BAXTER PHARMACEUTICALS INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"535","totalValueFC":"54013.4","currency":"USD","unitRateINR":"46411.3","date":"17-Jun-2025","totalValueINR":"4641125","totalValueInUsd":"54013.4","indian_port":"Ahmedabad Air","hs_no":"29339990","bill_no":"2703810","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"POL.IND.RUBI SUR- CESAR MARTINELI I BRUNET 12A 08191-RUBI Barcelona Barcelona, , SPAIN SPAIN","customerAddress":"CLARIS CORPORATE HEAD QUARTERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1758479400,"product":"BUPIVACAINE HYDROCHLORIDE BUPIVACAINE HYDROCHLORIDE","address":"NEELAM CENTRE, B WING, 4TH FLOOR,","city":"MUMBAI, MAHARASHTRA.","supplier":"CHEMESS DWC LLC","supplierCountry":"ITALY","foreign_port":"FLORENCE","customer":"J B CHEMICALS AND PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"922.8","totalValueFC":"23223","currency":"EURO","unitRateINR":"81995","date":"22-Sep-2025","totalValueINR":"2049875","totalValueInUsd":"23223","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"4653969","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"FLORENCE","supplierAddress":"POST BOX NO.115710 806 MARINA RESIDENCE 3 PALM JUMEIRA DUBAI, U.A.E UNITED ARAB EMIRATES","customerAddress":"NEELAM CENTRE, B WING, 4TH FLOOR,"}]
    12-Jan-2022
    05-Dec-2025
    KGS
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    Average Price (USD/KGS)

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    Drugs in Development

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    Efficacy of EXPAREL vs. Bupivacaine

    Details:

    Bupivacaine is a small molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Pain, Postoperative.


    Lead Product(s): Bupivacaine,Bupivacaine Hydrochloride

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Pacira BioSciences

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 08, 2025

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    01

    Gabrail Cancer Center Research

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    Not Confirmed

    Gabrail Cancer Center Research

    Country
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    Not Confirmed
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    Lead Product(s) : Bupivacaine,Bupivacaine Hydrochloride

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Pacira BioSciences

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Efficacy of EXPAREL vs. Bupivacaine

    Details : Bupivacaine is a small molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Pain, Postoperative.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    October 08, 2025

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    MedinCell Announces Successful Completion of Patient Enrollment in the Phase 3 Study of F14 (mdc-CWM), a First-in-Class Therapy for Localized Pain Relie...

    Details:

    F14 (celecoxib) is a sustained-release formulation of the non-steroidal anti-inflammatory drug (NSAID), celecoxib, administered into the intra-articular space at the end of TKR surgery.


    Lead Product(s): Celecoxib,Paracetamol,Bupivacaine Hydrochloride

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable August 30, 2023

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    02

    MedinCell

    France
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    Not Confirmed

    MedinCell

    France
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    Not Confirmed
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    Lead Product(s) : Celecoxib,Paracetamol,Bupivacaine Hydrochloride

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    MedinCell Announces Successful Completion of Patient Enrollment in the Phase 3 Study of F14 (mdc-C...

    Details : F14 (celecoxib) is a sustained-release formulation of the non-steroidal anti-inflammatory drug (NSAID), celecoxib, administered into the intra-articular space at the end of TKR surgery.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    August 30, 2023

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    Acasti Pharma Announces Preliminary Topline Results Met All Primary Outcome Measures in the Single Dose Pharmacokinetic Study for GTX-101, the Companyâ€...

    Details:

    GTX-101 is a novel formulation of bupivacaine hydrochloride for topical administration via a bio-adhesive, film-forming polymer, for relief of pain associated with Postherpetic Neuralgia, a neuropathic pain caused by nerve damage from the varicella zoster virus (shingles).


    Lead Product(s): Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable December 22, 2022

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    03

    Grace Therapeutics

    U.S.A
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    Not Confirmed

    Grace Therapeutics

    U.S.A
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    Not Confirmed
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    Lead Product(s) : Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Acasti Pharma Announces Preliminary Topline Results Met All Primary Outcome Measures in the Single...

    Details : GTX-101 is a novel formulation of bupivacaine hydrochloride for topical administration via a bio-adhesive, film-forming polymer, for relief of pain associated with Postherpetic Neuralgia, a neuropathic pain caused by nerve damage from the varicella zoste...

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    December 22, 2022

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    A Phase 3 Study of F14 for Management of Pain Following Total Knee Replacement

    Details:

    F14 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Pain, Postoperative.


    Lead Product(s): F14,Bupivacaine Hydrochloride,Paracetamol,Methocarbamol

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IIIProduct Type: Miscellaneous

    Sponsor: Allucent

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable November 03, 2022

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    04

    Arthritis Innovation Corporation

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    Not Confirmed

    Arthritis Innovation Corporation

    Country
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    Not Confirmed
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    Lead Product(s) : F14,Bupivacaine Hydrochloride,Paracetamol,Methocarbamol

    Therapeutic Area : Neurology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Allucent

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    A Phase 3 Study of F14 for Management of Pain Following Total Knee Replacement

    Details : F14 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Pain, Postoperative.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    November 03, 2022

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    Acasti Pharma Announces Initiation of Pharmacokinetic Study for GTX-101, the Company’s Drug Candidate for the Treatment of Postherpetic Neuralgia

    Details:

    GTX-101 (bupivacaine hydrochloride) topical administration via bio-adhesive, film-forming polymer, for relief of pain associated with PHN, a persistent and often debilitating neuropathic pain caused by nerve damage from shingles, which may persist for months and even years.


    Lead Product(s): Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 27, 2022

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    05

    Grace Therapeutics

    U.S.A
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    VMX
    Not Confirmed

    Grace Therapeutics

    U.S.A
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    Not Confirmed
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    Lead Product(s) : Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Acasti Pharma Announces Initiation of Pharmacokinetic Study for GTX-101, the Company’s Drug Cand...

    Details : GTX-101 (bupivacaine hydrochloride) topical administration via bio-adhesive, film-forming polymer, for relief of pain associated with PHN, a persistent and often debilitating neuropathic pain caused by nerve damage from shingles, which may persist for mo...

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    July 27, 2022

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    Innocoll Announces Publication of Positive Results from Pivotal Clinical Trial of POSIMIR in Arthroscopic Subacromial Decompression

    Details:

    POSIMIR® (bupivacaine solution) for infiltration use reduced mean pain over 72 hours after arthroscopic subacromial decompression surgery compared with vehicle control and improved several measures of postoperative opioid use.


    Lead Product(s): Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area: Neurology Brand Name: Xaracoll

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 06, 2022

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    06

    Innocoll Pharmaceuticals Limited

    Ireland
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    Not Confirmed

    Innocoll Pharmaceuticals Limited

    Ireland
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    Not Confirmed
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    Lead Product(s) : Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Innocoll Announces Publication of Positive Results from Pivotal Clinical Trial of POSIMIR in Arthr...

    Details : POSIMIR® (bupivacaine solution) for infiltration use reduced mean pain over 72 hours after arthroscopic subacromial decompression surgery compared with vehicle control and improved several measures of postoperative opioid use.

    Product Name : Xaracoll

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    July 06, 2022

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    Innocoll Announces Positive Topline Results For XARACOLL® (bupivacaine hydrochloride) Implant in a Phase 3 Study to Support Expanded Use

    Details:

    XARACOLL (Bupivacaine HCl), an innovative collagen drug-device implant, 300mg dose cohort experienced less pain and, was generally well tolerated with an adverse event profile comparable to the current prescribing information.


    Lead Product(s): Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area: Neurology Brand Name: Xaracoll

    Study Phase: Approved FDFProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 02, 2022

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    07

    Innocoll Pharmaceuticals Limited

    Ireland
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    Not Confirmed

    Innocoll Pharmaceuticals Limited

    Ireland
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    Not Confirmed
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    Lead Product(s) : Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Innocoll Announces Positive Topline Results For XARACOLL® (bupivacaine hydrochloride) Implant in ...

    Details : XARACOLL (Bupivacaine HCl), an innovative collagen drug-device implant, 300mg dose cohort experienced less pain and, was generally well tolerated with an adverse event profile comparable to the current prescribing information.

    Product Name : Xaracoll

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    March 02, 2022

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    Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection

    Details:

    Tylenol is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Pain, Postoperative.


    Lead Product(s): Paracetamol,Methocarbamol,Tramadol Hydrochloride,Bupivacaine Hydrochloride,Epinephrine

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IVProduct Type: Miscellaneous

    Sponsor: AtriCure

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable December 03, 2021

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    08

    Medical College of Wisconsin

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    Not Confirmed

    Medical College of Wisconsin

    Country
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    Not Confirmed
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    Lead Product(s) : Paracetamol,Methocarbamol,Tramadol Hydrochloride,Bupivacaine Hydrochloride,Epinephrine

    Therapeutic Area : Neurology

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : AtriCure

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection

    Details : Tylenol is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Pain, Postoperative.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    December 03, 2021

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    Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

    Details:

    Bupivacaine is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Pain, Postoperative.


    Lead Product(s): Bupivacaine,Bupivacaine Hydrochloride

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IVProduct Type: Miscellaneous

    Sponsor: MaineHealth

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable December 01, 2021

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    09

    Ryan Mountjoy, MD

    Country
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    Not Confirmed

    Ryan Mountjoy, MD

    Country
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    Not Confirmed
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    Lead Product(s) : Bupivacaine,Bupivacaine Hydrochloride

    Therapeutic Area : Neurology

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : MaineHealth

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

    Details : Bupivacaine is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Pain, Postoperative.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    December 01, 2021

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    Acasti Pharma Awarded Composition-of-Matter Patents for GTX-101 in Europe, China and Mexico and for GTX-102 in Japan

    Details:

    GTX-101, a novel bio-adhesive film forming topical spray formulation of bupivacaine for the treatment of Postherpetic Neuralgia (PHN). GTX-101 could provide significant benefits faster onset of action and longer duration of pain relief over current standard of care.


    Lead Product(s): Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area: Neurology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 06, 2021

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    Grace Therapeutics

    U.S.A
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    VMX
    Not Confirmed

    Grace Therapeutics

    U.S.A
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    VMX
    Not Confirmed
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Bupivacaine Hydrochloride,Inapplicable

    Therapeutic Area : Neurology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Acasti Pharma Awarded Composition-of-Matter Patents for GTX-101 in Europe, China and Mexico and fo...

    Details : GTX-101, a novel bio-adhesive film forming topical spray formulation of bupivacaine for the treatment of Postherpetic Neuralgia (PHN). GTX-101 could provide significant benefits faster onset of action and longer duration of pain relief over current stand...

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    October 06, 2021

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    DOSAGE - INJECTABLE;INJECTION - 0.25%

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.25%;0.0091M...DOSAGE - INJECTABLE;INJECTION - 0.25%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.5%

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG...DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.75%

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.75%;0.0091M...DOSAGE - INJECTABLE;INJECTION - 0.75%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 16964

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    DOSAGE - INJECTABLE;INJECTION - 0.25%

    USFDA APPLICATION NUMBER - 18304

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    DOSAGE - INJECTABLE;INJECTION - 0.5%

    USFDA APPLICATION NUMBER - 18304

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    DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG...DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 18304

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    DOSAGE - INJECTABLE;INJECTION - 0.75%

    USFDA APPLICATION NUMBER - 18304

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    DOSAGE - INJECTABLE;INJECTION - 0.75%;0.0091M...DOSAGE - INJECTABLE;INJECTION - 0.75%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 18304

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    DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG...DOSAGE - INJECTABLE;INJECTION - 0.5%;0.0091MG/ML

    USFDA APPLICATION NUMBER - 22046

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    ABOUT THIS PAGE

    Looking for 14252-80-3 / Bupivacaine Hydrochloride API manufacturers, exporters & distributors?

    Bupivacaine Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Bupivacaine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Bupivacaine Hydrochloride manufacturer or Bupivacaine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Bupivacaine Hydrochloride manufacturer or Bupivacaine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Bupivacaine Hydrochloride API Price utilized in the formulation of products. Bupivacaine Hydrochloride API Price is not always fixed or binding as the Bupivacaine Hydrochloride Price is obtained through a variety of data sources. The Bupivacaine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Bupivacaine Hydrochloride

    Synonyms

    Bupivacaine hcl, 18010-40-7, 14252-80-3, Carbostesin, Vivacaine, Sensorcaine

    Cas Number

    14252-80-3

    Unique Ingredient Identifier (UNII)

    AKA908P8J1

    About Bupivacaine Hydrochloride

    A widely used local anesthetic agent.

    Bupivacaine HCL Manufacturers

    A Bupivacaine HCL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bupivacaine HCL, including repackagers and relabelers. The FDA regulates Bupivacaine HCL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bupivacaine HCL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Bupivacaine HCL manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Bupivacaine HCL Suppliers

    A Bupivacaine HCL supplier is an individual or a company that provides Bupivacaine HCL active pharmaceutical ingredient (API) or Bupivacaine HCL finished formulations upon request. The Bupivacaine HCL suppliers may include Bupivacaine HCL API manufacturers, exporters, distributors and traders.

    click here to find a list of Bupivacaine HCL suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Bupivacaine HCL USDMF

    A Bupivacaine HCL DMF (Drug Master File) is a document detailing the whole manufacturing process of Bupivacaine HCL active pharmaceutical ingredient (API) in detail. Different forms of Bupivacaine HCL DMFs exist exist since differing nations have different regulations, such as Bupivacaine HCL USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Bupivacaine HCL DMF submitted to regulatory agencies in the US is known as a USDMF. Bupivacaine HCL USDMF includes data on Bupivacaine HCL's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Bupivacaine HCL USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Bupivacaine HCL suppliers with USDMF on PharmaCompass.

    Bupivacaine HCL JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Bupivacaine HCL Drug Master File in Japan (Bupivacaine HCL JDMF) empowers Bupivacaine HCL API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Bupivacaine HCL JDMF during the approval evaluation for pharmaceutical products. At the time of Bupivacaine HCL JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Bupivacaine HCL suppliers with JDMF on PharmaCompass.

    Bupivacaine HCL KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Bupivacaine HCL Drug Master File in Korea (Bupivacaine HCL KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Bupivacaine HCL. The MFDS reviews the Bupivacaine HCL KDMF as part of the drug registration process and uses the information provided in the Bupivacaine HCL KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Bupivacaine HCL KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Bupivacaine HCL API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Bupivacaine HCL suppliers with KDMF on PharmaCompass.

    Bupivacaine HCL CEP

    A Bupivacaine HCL CEP of the European Pharmacopoeia monograph is often referred to as a Bupivacaine HCL Certificate of Suitability (COS). The purpose of a Bupivacaine HCL CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Bupivacaine HCL EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Bupivacaine HCL to their clients by showing that a Bupivacaine HCL CEP has been issued for it. The manufacturer submits a Bupivacaine HCL CEP (COS) as part of the market authorization procedure, and it takes on the role of a Bupivacaine HCL CEP holder for the record. Additionally, the data presented in the Bupivacaine HCL CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Bupivacaine HCL DMF.

    A Bupivacaine HCL CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Bupivacaine HCL CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Bupivacaine HCL suppliers with CEP (COS) on PharmaCompass.

    Bupivacaine HCL WC

    A Bupivacaine HCL written confirmation (Bupivacaine HCL WC) is an official document issued by a regulatory agency to a Bupivacaine HCL manufacturer, verifying that the manufacturing facility of a Bupivacaine HCL active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Bupivacaine HCL APIs or Bupivacaine HCL finished pharmaceutical products to another nation, regulatory agencies frequently require a Bupivacaine HCL WC (written confirmation) as part of the regulatory process.

    click here to find a list of Bupivacaine HCL suppliers with Written Confirmation (WC) on PharmaCompass.

    Bupivacaine HCL NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Bupivacaine HCL as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Bupivacaine HCL API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Bupivacaine HCL as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Bupivacaine HCL and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Bupivacaine HCL NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Bupivacaine HCL suppliers with NDC on PharmaCompass.

    Bupivacaine HCL GMP

    Bupivacaine HCL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Bupivacaine HCL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bupivacaine HCL GMP manufacturer or Bupivacaine HCL GMP API supplier for your needs.

    Bupivacaine HCL CoA

    A Bupivacaine HCL CoA (Certificate of Analysis) is a formal document that attests to Bupivacaine HCL's compliance with Bupivacaine HCL specifications and serves as a tool for batch-level quality control.

    Bupivacaine HCL CoA mostly includes findings from lab analyses of a specific batch. For each Bupivacaine HCL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Bupivacaine HCL may be tested according to a variety of international standards, such as European Pharmacopoeia (Bupivacaine HCL EP), Bupivacaine HCL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bupivacaine HCL USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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