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1. Indole Hydrochloride
2. Indole, 14c-labeled
1. 1h-indole
2. 120-72-9
3. 2,3-benzopyrrole
4. Indol
5. 1-benzazole
6. Ketole
7. 1-azaindene
8. Benzopyrrole
9. 2,3-benzopyrole
10. Caswell No. 498b
11. Indol [german]
12. Indole (natural)
13. 1-benzo(b)pyrrole
14. 1h-benzo[b]pyrrole
15. Fema No. 2593
16. Ccris 4421
17. Hsdb 599
18. Epa Pesticide Chemical Code 025000
19. Benzo[b]pyrrole
20. Ai3-01540
21. 1h-indole, Homopolymer
22. Mfcd00005607
23. Chembl15844
24. Chebi:16881
25. 8724fjw4m5
26. Nsc-1964
27. Indole 100 Microg/ml In Acetonitrile
28. Ncgc00167539-01
29. Dsstox_cid_737
30. Dsstox_rid_75761
31. Dsstox_gsid_20737
32. 82451-55-6
33. Ind
34. Cas-120-72-9
35. Nsc 1964
36. Einecs 204-420-7
37. Benzazole
38. Mono-indole
39. Unii-8724fjw4m5
40. 1-h-indole
41. Indole, 7
42. Indolum
43. Indole (8ci)
44. Indole (white Flake)
45. Indole, 98%
46. 1h-indole (9ci)
47. Indolum [hpus]
48. Indole [fhfi]
49. Indole [hsdb]
50. Indole [fcc]
51. Indole [usp-rs]
52. Indole [mi]
53. Indole, >=99%
54. Schembl698
55. Bmse000097
56. Indole, Analytical Standard
57. Indole, >=99%, Fg
58. Wln: T56 Bmj
59. Bidd:gt0304
60. Schembl940818
61. Indole Benzo-pyrrole
62. Schembl1921769
63. Schembl9559244
64. Dtxsid0020737
65. Amy3411
66. Nsc1964
67. 185l
68. Bcp27232
69. Str01201
70. Tox21_112536
71. Tox21_201677
72. Tox21_302937
73. Bbl011739
74. Bdbm50094702
75. S6358
76. Stl163380
77. Zinc14516984
78. Akos000119629
79. Tox21_112536_1
80. Cg-0501
81. Cs-w001132
82. Db04532
83. Hy-w001132
84. Indole, Puriss., >=98.5% (gc)
85. Ncgc00167539-02
86. Ncgc00167539-03
87. Ncgc00256348-01
88. Ncgc00259226-01
89. Bp-10563
90. Ds-011308
91. Ft-0627211
92. I0021
93. C00463
94. I-0800
95. I-0810
96. Q319541
97. Sr-01000944736
98. Sr-01000944736-1
99. Z57833933
100. F2190-0647
| Molecular Weight | 117.15 g/mol |
|---|---|
| Molecular Formula | C8H7N |
| XLogP3 | 2.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 117.057849228 g/mol |
| Monoisotopic Mass | 117.057849228 g/mol |
| Topological Polar Surface Area | 15.8 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 101 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
INDOLE UNDERGOES SCISSION OF PYRROLE RING TO YIELD N-FORMYLANTHRANILIC ACID, AN UNSTABLE COMPD WHICH DECOMP INTO ANTHRANILIC ACID & FORMIC ACID. INDOLE IS FIRST HYDROXYLATED TO GIVE INDOXYL & THEN ISATIN, & IT IS PROBABLY LATTER WHICH UNDERGOES HYDROLYTIC RING OPENING.
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 69
...INDOLE IS METABOLIZED BY RAT TO INDOXYL, OXINDOLE, 5-HYDROXYOXINDOLE & ISATIN...
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 45
YIELDS 2,2-BIS(3-INDOLYL)INDOXYL IN HORSERADISH. DEOXYVIOLACEIN IN CHROMOBACTERIUM. CIS-6,7-DIHYDRO-6,7-DIHYDROXYINDOLE PROBABLY IN PSEUDOMONAS. /FROM TABLE/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. I-2
YIELDS 3,3'-DIINDOLYLACETIC ACID IN PEA. O-FORMAMIDOBENZALDEHYDE IN TECOMA. 3-HYDROXYOXINDOLE IN COCCUS. /FROM TABLE/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. I-3
For more Metabolism/Metabolites (Complete) data for INDOLE (10 total), please visit the HSDB record page.
Indole has known human metabolites that include 6-Hydroxyindole, Indoxyl, and Oxindole.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
The effects of heterocyclic cmpd on hepatic xenobiotic metabolizing enzymes were studied in mice. Female CD-1 mice were admin 5 u mol/kg coumarin, trimethylene oxide (TMO), or trimethylene sulfide (TMS) for 6 days by gavage, or benzofuran, indole, or indole-3-carbinol (IC) daily for 10 days. Animals were /sacrificed/ 1 or 2 days after the last dose; livers were removed and assayed for epoxide hydrolase, glutathione-S-transferase (GST), reduced NADH-quinone-reductase (NADH/QR), glucose-6-phosphate-dehydrogenase (G6PDH), glutathione-reductase (GSSG-red), uridine-diphosphate-glucose-dehydrogenase (UDPGDH), aniline-hydroxylase, 7-ethoxycoumarin-deethylase (ECOD), and cytochrome-c-reductase (cyt-c-red) activities, and cytochrome p450. All cmpd except indole, significantly enhanced epoxide hydrolase activity. GST activities were elevated by all cmpd except TMO and TMS. NADH/QR activity was incr only by coumarin and benzofuran. Indole incr only GST, UDPGDH and cyt-c-red activities. IC enhanced GST, UDPGDH, cyt-c-red, epoxide hydrolase and cytochrome p450 and related monooxygenase activities. Benzofuran and coumarin showed more varied responses. Both cmpd incr epoxide hydrolase, GST and NADH/QR activities. Benzofuran decr cytochrome p450 content and elevated ECOD activity.
Heine HS et al; Chemico-Biol Interact 59 (2): 219-30 (1986)
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A Benzopyrrole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Benzopyrrole, including repackagers and relabelers. The FDA regulates Benzopyrrole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Benzopyrrole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Benzopyrrole supplier is an individual or a company that provides Benzopyrrole active pharmaceutical ingredient (API) or Benzopyrrole finished formulations upon request. The Benzopyrrole suppliers may include Benzopyrrole API manufacturers, exporters, distributors and traders.
Benzopyrrole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Benzopyrrole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Benzopyrrole GMP manufacturer or Benzopyrrole GMP API supplier for your needs.
A Benzopyrrole CoA (Certificate of Analysis) is a formal document that attests to Benzopyrrole's compliance with Benzopyrrole specifications and serves as a tool for batch-level quality control.
Benzopyrrole CoA mostly includes findings from lab analyses of a specific batch. For each Benzopyrrole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Benzopyrrole may be tested according to a variety of international standards, such as European Pharmacopoeia (Benzopyrrole EP), Benzopyrrole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Benzopyrrole USP).
