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    Chemistry

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    Also known as: Retinyl palmitate, 79-81-2, Retinol palmitate, Retinol, hexadecanoate, All-trans-retinyl palmitate, Arovit
    Molecular Formula
    C36H60O2
    Molecular Weight
    524.9  g/mol
    InChI Key
    VYGQUTWHTHXGQB-FFHKNEKCSA-N
    FDA UNII
    1D1K0N0VVC
    Vitamin A Palmitate
    Retinyl Palmitate is a naturally-occurring phenyl analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. As the most common form of vitamin A taken for dietary supplementation, retinyl palmitate binds to and activates retinoid receptors, thereby inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation, induces apoptosis in some cancer cell types, and exhibits immunomodulatory properties. (NCI04)
    1 2D Structure

    Vitamin A Palmitate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate
    2.1.2 InChI
    InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
    2.1.3 InChI Key
    VYGQUTWHTHXGQB-FFHKNEKCSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C
    2.1.5 Isomeric SMILES
    CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(CCCC1(C)C)C
    2.2 Other Identifiers
    2.2.1 UNII
    1D1K0N0VVC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Chocola A

    2. Retinol Palmitate

    3. Retinyl Palmitate

    2.3.2 Depositor-Supplied Synonyms

    1. Retinyl Palmitate

    2. 79-81-2

    3. Retinol Palmitate

    4. Retinol, Hexadecanoate

    5. All-trans-retinyl Palmitate

    6. Arovit

    7. Optovit-a

    8. Retinyl Hexadecanoate

    9. Aquapalm

    10. Dispatabs Tabs

    11. Vitazyme A

    12. Optovit A

    13. Axerophthol Palmitate

    14. Trans-retinol Palmitate

    15. Trans-retinyl Palmitate

    16. [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] Hexadecanoate

    17. Lutavit A 500 Plus

    18. All-trans-retinol Palmitate

    19. Arovit (roche)

    20. All-trans-vitamin A Palmitate

    21. Aquasol A (tn)

    22. Retinyl (vitamin A) Palmitate

    23. Retinol Palmitate [jan]

    24. O~15~-hexadecanoylretinol

    25. Nsc-758478

    26. 1d1k0n0vvc

    27. Retinol, Palmitate, All-trans

    28. Ester Found In Fish Liver Oils

    29. Retinol Palmitate (6ci,7ci)

    30. Chebi:17616

    31. Palmitic Acid, Ester With Retinol

    32. Retinol, Palmitate, All-trans- (8ci)

    33. Ncgc00095056-03

    34. Dsstox_cid_1241

    35. Dsstox_rid_76033

    36. Dsstox_gsid_21241

    37. (2e,4e,6e,8e)-hexadecanoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2, 4,6,8,tetraenyl Ester

    38. Vitamin A Solubilized

    39. Cas-79-81-2

    40. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl Hexadecanoate

    41. Smr000112463

    42. Ccris 3280

    43. Retinol, Palmitate, All-trans-

    44. Einecs 201-228-5

    45. Unii-1d1k0n0vvc

    46. Brn 1917366

    47. Retinylpalmitate

    48. Retinol-palmitate

    49. Retinyl-palmitate

    50. Retinol, All-trans-, Palmitate

    51. Palmitic Acid Retinol

    52. Retinyl Palmitic Acid

    53. Vitamin- A Palmitate

    54. Retinyl Hexadecanoic Acid

    55. Spectrum5_001201

    56. All-(e)-retinol Palmitate

    57. Bmse000501

    58. Ec 201-228-5

    59. Retinol Palmitate (jp17)

    60. Chembl1675

    61. Schembl41649

    62. Mls001332437

    63. Mls001332438

    64. Spectrum1503604

    65. All-trans-retinyl Hexadecanoate

    66. Dtxsid1021241

    67. Retinyl Palmitate [inci]

    68. Hms500m11

    69. Retinyl Palmitate [vandf]

    70. Vitamin A Palmitate [mi]

    71. Hms1922e10

    72. Hms2093g13

    73. Hms2268c06

    74. Pharmakon1600-01503604

    75. Retinol Palmitate [who-dd]

    76. Retinyl Palmitate [usp-rs]

    77. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl Palmitate

    78. Amy13840

    79. Hy-b1384

    80. Vae 16:0

    81. Vitamin A Palmitate [vandf]

    82. Zinc8214494

    83. Tox21_113452

    84. Tox21_303008

    85. Ccg-39342

    86. Lmpr01090013

    87. Mfcd00019414

    88. Nsc758478

    89. S4126

    90. Retinol, O~15~-(1-oxohexadecyl)-

    91. Akos015918435

    92. Nsc 758478

    93. Vitamin A Palmitate, 1.7 M.i.u./g

    94. Idi1_000249

    95. Ncgc00095056-01

    96. Ncgc00095056-02

    97. Ncgc00256427-01

    98. Ac-20001

    99. Vitamin A Palmitate [orange Book]

    100. Sbi-0051830.p002

    101. All-(e)-retinol Palmitate [who-ip]

    102. Cs-0013116

    103. C02588

    104. C76552

    105. D00164

    106. Ab00052360_04

    107. A839762

    108. Sr-05000001910

    109. Vitamin A Palmitate (solubilized) [vandf]

    110. Q7316807

    111. Sr-05000001910-1

    112. Retinyl Palmitate (vitamin A Palmitate; Retinol Palmitate)

    113. Retinyl Palmitate, Potency: >=1,700,000 Usp Units Per G

    114. Vitamin A (as Palmitate & Beta Carotene) [vandf]

    115. Retinyl Palmitate, Type Iv, ~1,800,000 Usp Units/g, Oil

    116. Retinyl Palmitate, United States Pharmacopeia (usp) Reference Standard

    117. [3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] Hexadecanoate

    118. 3,7-dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol Palmitate

    119. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-en-1-yl)-2,4,6,8-nonateetraen-1-yl-palmitate

    120. (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenyl Palmitate

    121. 110067-62-4

    122. Hexadecanoic Acid [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenyl] Ester

    123. Retinyl Palmitate (vitamin A Palmitate), Pharmaceutical Secondary Standard; Certified Reference Material

    124. Retinyl Palmitate Solution, 100 Mug/ml (ethanol With 0.1% (w/v) Bht), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 524.9 g/mol
    Molecular Formula C36H60O2
    XLogP313.6
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count21
    Exact Mass524.45933115 g/mol
    Monoisotopic Mass524.45933115 g/mol
    Topological Polar Surface Area26.3 Ų
    Heavy Atom Count38
    Formal Charge0
    Complexity803
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count4
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anticarcinogenic Agents

    Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)

    Antioxidants

    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

    API Reference Price

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    06-Jan-2021
    31-Mar-2025
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - INJECTABLE;INJECTION - EQ 50,000 UNI...DOSAGE - INJECTABLE;INJECTION - EQ 50,000 UNITS BASE/ML

    USFDA APPLICATION NUMBER - 6823

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    ABOUT THIS PAGE

    Looking for 79-81-2 / Vitamin A Palmitate API manufacturers, exporters & distributors?

    Vitamin A Palmitate manufacturers, exporters & distributors 1

    84

    PharmaCompass offers a list of Vitamin A Palmitate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vitamin A Palmitate manufacturer or Vitamin A Palmitate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vitamin A Palmitate manufacturer or Vitamin A Palmitate supplier.

    PharmaCompass also assists you with knowing the Vitamin A Palmitate API Price utilized in the formulation of products. Vitamin A Palmitate API Price is not always fixed or binding as the Vitamin A Palmitate Price is obtained through a variety of data sources. The Vitamin A Palmitate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Vitamin A Palmitate

    Synonyms

    Retinyl palmitate, 79-81-2, Retinol palmitate, Retinol, hexadecanoate, All-trans-retinyl palmitate, Arovit

    Cas Number

    79-81-2

    Unique Ingredient Identifier (UNII)

    1D1K0N0VVC

    About Vitamin A Palmitate

    Retinyl Palmitate is a naturally-occurring phenyl analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. As the most common form of vitamin A taken for dietary supplementation, retinyl palmitate binds to and activates retinoid receptors, thereby inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation, induces apoptosis in some cancer cell types, and exhibits immunomodulatory properties. (NCI04)

    Arovit Manufacturers

    A Arovit manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Arovit, including repackagers and relabelers. The FDA regulates Arovit manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Arovit API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Arovit manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Arovit Suppliers

    A Arovit supplier is an individual or a company that provides Arovit active pharmaceutical ingredient (API) or Arovit finished formulations upon request. The Arovit suppliers may include Arovit API manufacturers, exporters, distributors and traders.

    click here to find a list of Arovit suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Arovit USDMF

    A Arovit DMF (Drug Master File) is a document detailing the whole manufacturing process of Arovit active pharmaceutical ingredient (API) in detail. Different forms of Arovit DMFs exist exist since differing nations have different regulations, such as Arovit USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Arovit DMF submitted to regulatory agencies in the US is known as a USDMF. Arovit USDMF includes data on Arovit's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Arovit USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Arovit suppliers with USDMF on PharmaCompass.

    Arovit JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Arovit Drug Master File in Japan (Arovit JDMF) empowers Arovit API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Arovit JDMF during the approval evaluation for pharmaceutical products. At the time of Arovit JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Arovit suppliers with JDMF on PharmaCompass.

    Arovit GMP

    Arovit Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Arovit GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Arovit GMP manufacturer or Arovit GMP API supplier for your needs.

    Arovit CoA

    A Arovit CoA (Certificate of Analysis) is a formal document that attests to Arovit's compliance with Arovit specifications and serves as a tool for batch-level quality control.

    Arovit CoA mostly includes findings from lab analyses of a specific batch. For each Arovit CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Arovit may be tested according to a variety of international standards, such as European Pharmacopoeia (Arovit EP), Arovit JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Arovit USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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