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Also known as: 5-methyl-2-pentylphenol, 1300-94-3, 5-methyl-2-n-pentylphenol, 6-pentyl-m-cresol, 6-amyl-m-cresol, 6-n-amyl-m-cresol
Molecular Formula
C12H18O
Molecular Weight
178.27  g/mol
InChI Key
CKGWFZQGEQJZIL-UHFFFAOYSA-N
FDA UNII
05W904P57F

Amylmetacresol
Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections,. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition.
1 2D Structure

Amylmetacresol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-methyl-2-pentylphenol
2.1.2 InChI
InChI=1S/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3
2.1.3 InChI Key
CKGWFZQGEQJZIL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCCCC1=C(C=C(C=C1)C)O
2.2 Other Identifiers
2.2.1 UNII
05W904P57F
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 5-methyl-2-pentylphenol

2. 1300-94-3

3. 5-methyl-2-n-pentylphenol

4. 6-pentyl-m-cresol

5. 6-amyl-m-cresol

6. 6-n-amyl-m-cresol

7. 6-n-pentyl-m-cresol

8. Amylmetacresolum

9. Phenol, 5-methyl-2-pentyl-

10. Amyl Metacresol

11. 2-amyl-5-methylphenol

12. Chebi:48213

13. 05w904p57f

14. Ncgc00180998-01

15. Amilmetacresol

16. Amilmetacresol [spanish]

17. Amylmetacresolum [latin]

18. Amylmetacresol [inn:ban]

19. Brn 2440952

20. M-cresol, 6-pentyl-

21. Einecs 215-094-0

22. Unii-05w904p57f

23. Amylmetacresol [inn]

24. Dsstox_cid_26791

25. Dsstox_rid_81908

26. Dsstox_gsid_46791

27. 3-06-00-02005 (beilstein Handbook Reference)

28. Amylmetacresol [vandf]

29. Schembl302197

30. Amylmetacresol [mart.]

31. Amyl Metacresol [vandf]

32. Amylmetacresol [who-dd]

33. Chembl1512677

34. Dtxsid8046791

35. 6-n-amyl-m-cresol [mi]

36. Baa30094

37. Zinc2039651

38. Amylmetacresol [ep Impurity]

39. Tox21_112651

40. Amylmetacresol [ep Monograph]

41. Mfcd00127710

42. S6173

43. Stl453583

44. Akos015912095

45. Db13908

46. 5-methyl-2-n-pentylphenol, Aldrichcpr

47. Ds-15450

48. Cas-1300-94-3

49. Hy-121527

50. Cs-0082471

51. Ft-0620948

52. Amylmetacresol 100 Microg/ml In Acetonitrile

53. A888790

54. Sr-01000944860

55. Q1946346

56. Sr-01000944860-1

57. W-108357

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 178.27 g/mol
Molecular Formula C12H18O
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass178.135765193 g/mol
Monoisotopic Mass178.135765193 g/mol
Topological Polar Surface Area20.2 Ų
Heavy Atom Count13
Formal Charge0
Complexity133
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Sore throat, minor mouth and throat infections,,.


5 Pharmacology and Biochemistry
5.1 Pharmacology

The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission. In addition, it relieves symptoms of sore throat/irritation of the throat,. Amylmetacresol is thought to inhibit the inflammatory and pain mediators that are involved in the inflammation of the mouth and throat mucous membranes, as well as the sore throat.


5.2 Absorption, Distribution and Excretion

Absorption

Rapidly absorbed and eliminated.


5.3 Mechanism of Action

The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/proteinlipid interaction is responsible for this action. Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner.


API SUPPLIERS

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Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Deccan Nutraceuticals Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothDeccan Nutraceuticals: A global leader in the integrated development, manufacturing, and marketing of pharmaceutical products.

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Macsen Labs

India

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Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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Siegfried AG

Switzerland

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Siegfried AG

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SLN Pharmachem

India

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SLN Pharmachem

India

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Bioxera Pharma

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Bioxera Pharma

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CEP/COS

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Certificate Number : R1-CEP 2012-343 - Rev 01

Status : Valid

Issue Date : 2022-08-02

Type : Chemical

Substance Number : 2405

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Certificate Number : R1-CEP 2011-017 - Rev 00

Status : Valid

Issue Date : 2018-02-06

Type : Chemical

Substance Number : 2405

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Amylmetacresol EP

Date of Issue : 2022-09-07

Valid Till : 2025-07-02

Written Confirmation Number : WC-0248

Address of the Firm : Plot No. N-57, Anand Nagar, Additional M.I.D.C., Ambernath (East)-421506, Mahara...

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Listed Suppliers

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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Amylmetacresol

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
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Virtual BoothDeccan Nutraceuticals: A global leader in the integrated development, manufacturing, and marketing of pharmaceutical products.

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Amylmetacresol

About the Company : Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their co...

Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their commitment to quality and adherence to Current Good Manufacturing Practices (CGMP) are integral to their operations. The company has been successfully audited by USFDA (5 times) and EDQM (2 times). The company manufactures high quality phytochemicals, semi-synthetic and synthetic APIs. DNPL stands as a responsible pharmaceutical manufacturer, devoted to delivering premium products across all the regions we serve.
Deccan Nutraceuticals

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Macsen Labs

India
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Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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Amylmetacresol

About the Company : Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our c...

Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our comprehensive offerings extend to Contract Research & Custom Synthesis. With a legacy of over seven decades, Macsen combines tradition with innovation to meet the evolving needs of the chemical and pharmaceutical sectors. Our commitment to quality is evident in every aspect of our operations, from state-of-the-art manufacturing facilities to advanced analytical capabilities.
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Siegfried AG

Switzerland
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Siegfried AG

Switzerland
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Amylmetacresol

About the Company : As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmac...

As an internationally renowned outsourcing partner, we offer products and tailor-made service packages that are seamlessly embedded in the value chain of our customers. Our pharmaceutical industry partners benefit from a wide range of offers - from the development of active ingredients to development services for ready-made drugs, their approval and production to packaging and logistics. As a former fully integrated pharmaceutical company, Siegfried is now one of the few suppliers who can develop both active ingredients and ready-made drugs under one roof. This combination of experience and know-how is unique in the CDMO market.
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Amylmetacresol

About the Company : SLN Pharmachem was setup in 1997 with an objective to provide technology based products (Intermediates) for Pharmaceutical, Cosmetic and Fine Chemical Industry. SLN Pharmachem is a...

SLN Pharmachem was setup in 1997 with an objective to provide technology based products (Intermediates) for Pharmaceutical, Cosmetic and Fine Chemical Industry. SLN Pharmachem is an ISO certified and has its manufacturing unit backed up by professionals who are desirous in manufacturing new, difficult to produce molecules with success to achieve the best quality standards in the international competition.
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API Reference Price

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07-Jan-2022
02-May-2025
KGS
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FDF Dossiers

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01

Amylmetacresol

Brand Name : OROTHROAT PLUS BLACKCURRANT LOZENGES

Dosage Form : LOZ

Dosage Strength : 0.6mg

Packaging : 16X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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02

Amylmetacresol

Brand Name : OROTHROAT PLUS HONEY AND LEMON LOZENGES

Dosage Form : LOZ

Dosage Strength : 0.6mg

Packaging : 16X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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03

AGGSpend
Not Confirmed
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2,4-Dichlorobenzyl alcohol; Amylmetacresol

Brand Name :

Dosage Form : Lozenge

Dosage Strength : 1.2MG; 0.6MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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04

AGGSpend
Not Confirmed
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Amylmetacresol

Brand Name : Swaas throat spray

Dosage Form : Topical Spray

Dosage Strength : 0.223%

Packaging : 50 to 200g

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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05

AGGSpend
Not Confirmed
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AMYLMETACRESOL

Brand Name : ANTIBACTERIAL THROAT LOZENGES

Dosage Form : LOZENGE

Dosage Strength : 0.6MG

Packaging : 24

Approval Date :

Application Number : 2375567

Regulatory Info :

Registration Country : Canada

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06

Reckitt Benckiser

United Kingdom
AGGSpend
Not Confirmed
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Reckitt Benckiser

United Kingdom
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AGGSpend
Not Confirmed

AMYLMETACRESOL

Brand Name : CEPACOL SENSATIONS SORE THROAT & BLOCKED NOSE

Dosage Form : LOZENGE

Dosage Strength : 0.6MG

Packaging : 8/10/12/16/24/32

Approval Date :

Application Number : 2382881

Regulatory Info :

Registration Country : Canada

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07

Reckitt Benckiser

United Kingdom
AGGSpend
Not Confirmed
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Reckitt Benckiser

United Kingdom
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AGGSpend
Not Confirmed

AMYLMETACRESOL

Brand Name : CEPACOL SENSATIONS

Dosage Form : LOZENGE

Dosage Strength : 0.6MG

Packaging :

Approval Date :

Application Number : 2382938

Regulatory Info :

Registration Country : Canada

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08

Reckitt Benckiser

United Kingdom
AGGSpend
Not Confirmed
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Reckitt Benckiser

United Kingdom
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AGGSpend
Not Confirmed

AMYLMETACRESOL

Brand Name : CEPACOL SENSATIONS SORE THROAT & COUGH

Dosage Form : LOZENGE

Dosage Strength : 0.6MG

Packaging :

Approval Date :

Application Number : 2388642

Regulatory Info :

Registration Country : Canada

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09

Reckitt Benckiser

United Kingdom
AGGSpend
Not Confirmed
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Reckitt Benckiser

United Kingdom
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AGGSpend
Not Confirmed

AMYLMETACRESOL

Brand Name : CEPACOL CHILDREN'S FRUITY STRAWBERRY

Dosage Form : LOZENGE

Dosage Strength : 0.6MG

Packaging : 8/10/12/16/24/32

Approval Date :

Application Number : 2404982

Regulatory Info :

Registration Country : Canada

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10

Reckitt Benckiser

United Kingdom
AGGSpend
Not Confirmed
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Reckitt Benckiser

United Kingdom
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AGGSpend
Not Confirmed

Amylmetacresol

Brand Name : Nurofen Period Pain

Dosage Form : TAB

Dosage Strength : 10mg

Packaging : 12X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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EDQM

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01

EDQM, Council of Europe

Amylmetacresol for peak identification

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01

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Amylmetacresol for peak identification

CAS Number : 1300-94-3

Quantity Per Vial : 10 mg

Sale Unit : 1

Order Code : Y0001245

Batch No : 1

Price (€) : 79

Storage : +5°C ± 3°C

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02

EDQM, Council of Europe

Amylmetacresol

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02

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Amylmetacresol

CAS Number : 1300-94-3

Quantity Per Vial : 300 mg

Sale Unit : 1

Order Code : Y0001244

Batch No : 2

Price (€) : 79

Storage : +5°C ± 3°C

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ABOUT THIS PAGE

Looking for 53043-14-4 / Amylmetacresol API manufacturers, exporters & distributors?

Amylmetacresol manufacturers, exporters & distributors 1

27

PharmaCompass offers a list of Amylmetacresol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Amylmetacresol manufacturer or Amylmetacresol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Amylmetacresol manufacturer or Amylmetacresol supplier.

PharmaCompass also assists you with knowing the Amylmetacresol API Price utilized in the formulation of products. Amylmetacresol API Price is not always fixed or binding as the Amylmetacresol Price is obtained through a variety of data sources. The Amylmetacresol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Amylmetacresol

Synonyms

5-methyl-2-pentylphenol, 1300-94-3, 5-methyl-2-n-pentylphenol, 6-pentyl-m-cresol, 6-amyl-m-cresol, 6-n-amyl-m-cresol

Cas Number

53043-14-4

Unique Ingredient Identifier (UNII)

05W904P57F

About Amylmetacresol

Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections,. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition.

Amylmetacresol Manufacturers

A Amylmetacresol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Amylmetacresol, including repackagers and relabelers. The FDA regulates Amylmetacresol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Amylmetacresol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Amylmetacresol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Amylmetacresol Suppliers

A Amylmetacresol supplier is an individual or a company that provides Amylmetacresol active pharmaceutical ingredient (API) or Amylmetacresol finished formulations upon request. The Amylmetacresol suppliers may include Amylmetacresol API manufacturers, exporters, distributors and traders.

click here to find a list of Amylmetacresol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Amylmetacresol CEP

A Amylmetacresol CEP of the European Pharmacopoeia monograph is often referred to as a Amylmetacresol Certificate of Suitability (COS). The purpose of a Amylmetacresol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Amylmetacresol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Amylmetacresol to their clients by showing that a Amylmetacresol CEP has been issued for it. The manufacturer submits a Amylmetacresol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Amylmetacresol CEP holder for the record. Additionally, the data presented in the Amylmetacresol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Amylmetacresol DMF.

A Amylmetacresol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Amylmetacresol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Amylmetacresol suppliers with CEP (COS) on PharmaCompass.

Amylmetacresol WC

A Amylmetacresol written confirmation (Amylmetacresol WC) is an official document issued by a regulatory agency to a Amylmetacresol manufacturer, verifying that the manufacturing facility of a Amylmetacresol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Amylmetacresol APIs or Amylmetacresol finished pharmaceutical products to another nation, regulatory agencies frequently require a Amylmetacresol WC (written confirmation) as part of the regulatory process.

click here to find a list of Amylmetacresol suppliers with Written Confirmation (WC) on PharmaCompass.

Amylmetacresol GMP

Amylmetacresol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Amylmetacresol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Amylmetacresol GMP manufacturer or Amylmetacresol GMP API supplier for your needs.

Amylmetacresol CoA

A Amylmetacresol CoA (Certificate of Analysis) is a formal document that attests to Amylmetacresol's compliance with Amylmetacresol specifications and serves as a tool for batch-level quality control.

Amylmetacresol CoA mostly includes findings from lab analyses of a specific batch. For each Amylmetacresol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Amylmetacresol may be tested according to a variety of international standards, such as European Pharmacopoeia (Amylmetacresol EP), Amylmetacresol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Amylmetacresol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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