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    Chemistry

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    Also known as:
    Molecular Formula
    C8H11N5O3
    Molecular Weight
    225.20  g/mol
    InChI Key
    MKUXAQIIEYXACX-UHFFFAOYSA-N
    Aciclovir
    1 2D Structure

    Aciclovir

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
    2.1.2 InChI
    InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
    2.1.3 InChI Key
    MKUXAQIIEYXACX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=NC2=C(N1COCCO)NC(=NC2=O)N
    2.1.5 Isomeric SMILES
    C1=NC2=C(N1COCCO)NC(=NC2=O)N
    2.2 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 225.20 g/mol
    Molecular Formula C8H11N5O3
    XLogP3-1.6
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass225.08618923 g/mol
    Monoisotopic Mass225.08618923 g/mol
    Topological Polar Surface Area115 A^2
    Heavy Atom Count16
    Formal Charge0
    Complexity308
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 8  
    Drug NameAcyclovir
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topical administration. Each gram of ZOVIRAXCream 5% contains 50mg of acyclovir and the following inactiv...
    Active IngredientAcyclovir
    Dosage FormOintment; Tablet; Capsule; Suspension
    RouteTopical; Oral
    Strength5%; 200mg/5ml; 200mg; 800mg; 400mg
    Market StatusPrescription
    CompanyAmneal Pharms; Mylan Pharms; Ranbaxy; Hetero Labs Ltd V; Hi Tech Pharma; Actavis Mid Atlantic; Teva; Cadila Pharms; Apotex; Zydus Pharms Usa; Carlsbad; Mylan; Stason; Dava Pharms

    2 of 8  
    Drug NameAcyclovir sodium
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelAcyclovir is a synthetic nucleoside analog active against herpes viruses. Acyclovir for Injection USP is a sterile lyophilized powder for intravenous administration only. Each 500 mg vial contains 500 mg of acyclovir and 49 mg of sodium, and each 100...
    Active IngredientAcyclovir sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 50mg base/ml; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyBedford; Fresenius Kabi Usa; Aurobindo Pharma

    3 of 8  
    Drug NameSitavig
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelSITAVIG (acyclovir) buccal tablet is applied topically to the gum and releases acyclovir as the buccal tablet gradually dissolves [see ClinicalPharmacology (12.3)]. Acyclovir is a synthetic purine nucleoside analogue active against herpes viruses. Th...
    Active IngredientAcyclovir
    Dosage FormTablet
    RouteBuccal
    Strength50mg
    Market StatusPrescription
    CompanyInnocutis Holdings

    4 of 8  
    Drug NameZovirax
    Drug LabelZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topical administration. Each gram of ZOVIRAXCream 5% contains 50mg of acyclovir and the following inactiv...
    Active IngredientAcyclovir
    Dosage FormOintment; Tablet; Cream; Capsule; Suspension
    RouteOral; Topical
    Strength200mg/5ml; 200mg; 800mg; 400mg; 5%
    Market StatusPrescription
    CompanyDelcor Asset; Valeant Bermuda

    5 of 8  
    Drug NameAcyclovir
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topical administration. Each gram of ZOVIRAXCream 5% contains 50mg of acyclovir and the following inactiv...
    Active IngredientAcyclovir
    Dosage FormOintment; Tablet; Capsule; Suspension
    RouteTopical; Oral
    Strength5%; 200mg/5ml; 200mg; 800mg; 400mg
    Market StatusPrescription
    CompanyAmneal Pharms; Mylan Pharms; Ranbaxy; Hetero Labs Ltd V; Hi Tech Pharma; Actavis Mid Atlantic; Teva; Cadila Pharms; Apotex; Zydus Pharms Usa; Carlsbad; Mylan; Stason; Dava Pharms

    6 of 8  
    Drug NameAcyclovir sodium
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelAcyclovir is a synthetic nucleoside analog active against herpes viruses. Acyclovir for Injection USP is a sterile lyophilized powder for intravenous administration only. Each 500 mg vial contains 500 mg of acyclovir and 49 mg of sodium, and each 100...
    Active IngredientAcyclovir sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 50mg base/ml; eq 500mg base/vial; eq 1gm base/vial
    Market StatusPrescription
    CompanyBedford; Fresenius Kabi Usa; Aurobindo Pharma

    7 of 8  
    Drug NameSitavig
    PubMed HealthAcyclovir
    Drug ClassesAntiviral
    Drug LabelSITAVIG (acyclovir) buccal tablet is applied topically to the gum and releases acyclovir as the buccal tablet gradually dissolves [see ClinicalPharmacology (12.3)]. Acyclovir is a synthetic purine nucleoside analogue active against herpes viruses. Th...
    Active IngredientAcyclovir
    Dosage FormTablet
    RouteBuccal
    Strength50mg
    Market StatusPrescription
    CompanyInnocutis Holdings

    8 of 8  
    Drug NameZovirax
    Drug LabelZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topical administration. Each gram of ZOVIRAXCream 5% contains 50mg of acyclovir and the following inactiv...
    Active IngredientAcyclovir
    Dosage FormOintment; Tablet; Cream; Capsule; Suspension
    RouteOral; Topical
    Strength200mg/5ml; 200mg; 800mg; 400mg; 5%
    Market StatusPrescription
    CompanyDelcor Asset; Valeant Bermuda

    API Reference Price

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    02-Jan-2021
    31-Aug-2024
    KGS
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    DOSAGE - CAPSULE;ORAL - 200MG **Federal Regis...DOSAGE - CAPSULE;ORAL - 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18828

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    DOSAGE - SUSPENSION;ORAL - 200MG/5ML

    USFDA APPLICATION NUMBER - 19909

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    DOSAGE - TABLET;ORAL - 400MG **Federal Regist...DOSAGE - TABLET;ORAL - 400MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20089

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    DOSAGE - TABLET;ORAL - 800MG **Federal Regist...DOSAGE - TABLET;ORAL - 800MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20089

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    DOSAGE - CREAM;TOPICAL - 5%;1%

    USFDA APPLICATION NUMBER - 22436

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