Find Fluticasone Furoate manufacturers, exporters & distributors on PharmaCompass

Question

Looking for 397864-44-7 / Fluticasone Furoate API manufacturers, exporters & distributors?

API | Excipient name

Fluticasone Furoate

Synonyms

Veramyst, Avamys, 397864-44-7, Allermist, Furamist, Arnuity ellipta

Cas Number

397864-44-7

Unique Ingredient Identifier (UNII)

JS86977WNV

About Fluticasone Furoate

Fluticasone Furoate is the furoate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with anti-allergic, anti-inflammatory and anti-pruritic effects. Upon administration, fluticasone binds to and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2 and the cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, which leads to dephosphorylation and inactivation of Jun N-terminal kinase and directly inhibits c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibiting the transcription of cyclooxygenase 2 (COX-2), which is essential for prostaglandin production.

score 31 · Accepted Answer

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PharmaCompass also assists you with knowing the Fluticasone Furoate API Price utilized in the formulation of products. Fluticasone Furoate API Price is not always fixed or binding as the Fluticasone Furoate Price is obtained through a variety of data sources. The Fluticasone Furoate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

Molecular Formula	C₂₇H₂₉F₃O₆S
Molecular Weight	538.6 g/mol
XLogP3	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	538.16369430 g/mol
Monoisotopic Mass	538.16369430 g/mol
Topological Polar Surface Area	119 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	1080
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 2
Drug Name	Veramyst
PubMed Health	Fluticasone
Drug Classes	Anti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Strong
Drug Label	Fluticasone furoate, the active component of VERAMYST Nasal Spray, is a synthetic fluorinated corticosteroid having the chemical name (6,11,16,17)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-...
Active Ingredient	Fluticasone furoate
Dosage Form	Spray, metered
Route	Nasal
Strength	0.0275mg/inh
Market Status	Prescription
Company	Glaxosmithkline

2 of 2
Drug Name	Veramyst
PubMed Health	Fluticasone
Drug Classes	Anti-Inflammatory, Corticosteroid, Intermediate, Corticosteroid, Strong
Drug Label	Fluticasone furoate, the active component of VERAMYST Nasal Spray, is a synthetic fluorinated corticosteroid having the chemical name (6,11,16,17)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-...
Active Ingredient	Fluticasone furoate
Dosage Form	Spray, metered
Route	Nasal
Strength	0.0275mg/inh
Market Status	Prescription
Company	Glaxosmithkline

Find Fluticasone Furoate manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

38 API Suppliers

14 USDMF

4 CEP/COS

3 JDMF

5 EU WC

2 KDMF

19 NDC API

21 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

12 Drugs in Development

INTERMEDIATES

1 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

112 FDF Dossiers

9 FDA Orange Book

80 Europe

7 Canada

4 Australia

7 South Africa

5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

POWDER;INHALATION - 0.05MG/INH;EQ 0.025MG BASE/INH

POWDER;INHALATION - 0.1MG/INH;EQ 0.025MG BASE/INH

POWDER;INHALATION - 0.2MG/INH;EQ 0.025MG BASE/INH

POWDER;INHALATION - 0.05MG/INH

POWDER;INHALATION - 0.1MG/INH

POWDER;INHALATION - 0.2MG/INH

SPRAY, METERED;NASAL - 0.0275MG/SPRAY

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1 Ashland

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4 DFE Pharma

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6 Gangwal Chemicals

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17 Kerry

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12 Microlex e.U

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7 Roquette

6 Seppic

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EXCIPIENTS BY APPLICATIONS

37 Fillers, Diluents & Binders

18 Thickeners and Stabilizers

15 Solubilizers

12 Direct Compression

9 Lubricants & Glidants

8 Co-Processed Excipients

8 Granulation

7 Parenteral

6 Rheology Modifiers

5 Disintegrants & Superdisintegrants

4 Emulsifying Agents

4 Coating Systems & Additives

4 Film Formers & Plasticizers

3 Topical

3 Controlled & Modified Release