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Find Clinical Drug Pipeline Developments & Deals for Tox21_300749
Through the agreement, the company will prioritize the clinical development of FW-UP (niclosamide), currently undergoing Phase I/II clinical trial studies for the treatment of ulcerative colitis.
Xafty is a novel broad-spectrum antiviral with niclosamide's mechanism that eliminates viruses that infiltrated cells and can solve RNA virus infections, capable of treating both COVID-19 and Dengue fever or Dengue virus infection.
Xafty's active ingredient, niclosamide's mechanism is to remove viruses by activating cell autophagy, it is being investigated for COVID-19 as an antiviral drug candidate.
Niclosamide is an antiviral, that shows potent activity against SARS-CoV-2. Niclosamide targets human cell pathways and the host’s ability to control viral replication as its MOA and is therefore resistant to mutation of the SARS-CoV-2 spike protein.
Niclosamide, is a Potent Inhibitor of SARS-CoV-2 with Activity Against Multiple Variants for the treatment of COVID-2019 infections, was recently shown to exhibit potent antiviral activity against SARS-CoV-2.
The PCT application, filed with the USPTO, covers methods of treating patients with multiple formulations of niclosamide for GI infections related to post-acute COVID-19 syndrome, also known as “long haul” COVID-19, in most major market countries throughout the world.
FW-UP is a niclosamide-based, small molecule anti-inflammatory inhibitor therapy under development for the treatment of ulcerative proctitis (UP) and ulcerative proctosigmoiditis (UPS).
The Company intends to use the net proceeds from the offering to pay a portion of the cash purchase price for its acquisition of First Wave Bio, Inc. and for FW-UP for ulcerative proctitis, manufacturing, clinical development and/or increases in working capital.
TFF previously completed a preclinical in vivo efficacy study that showed a seven-fold reduction in lung viral load in a hamster model when dry powder niclosamide was administered 24 hours after inoculation with SARS-CoV-2 when the disease was already severe.
Company believes that FW-COV (Niclosamide). Part 2 of RESERVOIR Trial has the potential to contribute to global need for new therapies against SARS2 based on the positive safety data observed with earlier published in vitro COVID efficacy data. Topline Data Expected 1H 2022.
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