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    [{"orgOrder":0,"company":"Corino Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Tolcapone","moa":"Catechol O-methyltransferase","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Corino Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral","sponsorNew":"Corino Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Corino Therapeutics \/ Inapplicable"}]

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                            01

                            Corino Therapeutics

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                            iPHEX India
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                            Corino Therapeutics

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                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Corino Therapeutics Announces Presentation of New Clinical Research Finding at the XVII International Symposiu...

                            Details : The results confirm that CRX-1008 is a potent TTR stabilizer in both plasma and CSF using established ex vivo assays. CRX-1008 normalized TTR concentration in plasma with an overall mean increase in plasma TTR tetramer concentration of 55%.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 15, 2020

                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Corino Therapeutics

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                            iPHEX India
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                            Corino Therapeutics

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                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Quotient Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            A Study Assessing the Safety and Pharmacokinetic Profile of Modified Release Formulations of Tolcapone

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 16, 2018

                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Quotient Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Boston University

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                            Boston University

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                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Corino Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (AT...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 19, 2018

                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Corino Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            SOM Biotech

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                            iPHEX India
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                            SOM Biotech

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                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hospital Vall d'Hebron

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Study of SOM0226 in Familial Amyloid Polyneuropathy

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 16, 2014

                            Lead Product(s) : Tolcapone

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hospital Vall d'Hebron

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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