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Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Martin Gutierrez","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Martin Gutierrez \/ Hackensack Meridian Health | Karyopharm Therapeutics","highestDevelopmentStatusID":"7","companyTruncated":"Martin Gutierrez \/ Hackensack Meridian Health | Karyopharm Therapeutics"},{"orgOrder":0,"company":"Sun Yat-sen University","sponsor":"Fudan University | Antengene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Sun Yat-sen University","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sun Yat-sen University \/ Fudan University | Antengene","highestDevelopmentStatusID":"7","companyTruncated":"Sun Yat-sen University \/ Fudan University | Antengene"},{"orgOrder":0,"company":"Tong Chen, MD","sponsor":"Antengene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cytotoxic Drug","year":"2023","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Tong Chen, MD","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Tong Chen, MD \/ Antengene","highestDevelopmentStatusID":"7","companyTruncated":"Tong Chen, MD \/ Antengene"},{"orgOrder":0,"company":"Antengene","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2021","type":"Inapplicable","leadProduct":"Selinexor","moa":"||Exportin-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Antengene","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Antengene \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Antengene \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals for Selinexor

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of adult patients with multiple myeloma.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          March 04, 2025

                          Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Phase 3 clinical trial evaluating a once-weekly dose of 60mg of Xpovio (selinexor) in combination with twice-daily ruxolitinib in treatment naïve patients with myelofibrosis.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : Selinexor,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : XPOVIO (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          October 17, 2024

                          Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Xpovio (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 24, 2024

                          Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : XPOVIO® (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 08, 2024

                          Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Xpovio (selinexor) is an approved, first-in-class, small molecule, exportin 1 inhibitor. It is given orally to adult patients for the treatment of relapsed/refractory diffuse large B-cell lymphoma.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 07, 2024

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of TP53 wild-type advanced or recurrent endometrial cancer.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          March 12, 2024

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          January 25, 2024

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : The collaboratin aims to evaluate the investigational cereblon E3 ligase modulator agent mezigdomide in combination with Karyopharm's selinexor, an approved first-in-class inhibitor of XPO1, plus dexamethasone in patients with relapsed/refractory multipl...

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 30, 2023

                          Lead Product(s) : Mezigdomide,Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Karyopharm Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          10

                          iPHEX India
                          Not Confirmed
                          iPHEX India
                          Not Confirmed

                          Details : Under the agreement, Hansoh will be exclusively responsible for commercialization of Xpovio (selinexor), world's first approved orally-available, selective inhibitor of the nuclear export protein XPO1, in the mainland of China for relapsed or refractory ...

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : $27.6 million

                          October 08, 2023

                          Lead Product(s) : Selinexor,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Hansoh Pharma

                          Deal Size : $101.5 million

                          Deal Type : Collaboration

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