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Squibb","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bristol Myers Squibb \/ Karyopharm Therapeutics","highestDevelopmentStatusID":"10","companyTruncated":"Bristol Myers Squibb \/ Karyopharm Therapeutics"},{"orgOrder":0,"company":"Washington University School of Medicine","sponsor":"Karyopharm Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2025","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase II","graph3":"Washington University School of Medicine","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Washington University School of Medicine \/ Karyopharm Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Washington University School of Medicine \/ Karyopharm Therapeutics"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Morten Mau-Soerensen","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2018","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase II","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Karyopharm Therapeutics \/ Morten Mau-Soerensen","highestDevelopmentStatusID":"8","companyTruncated":"Karyopharm Therapeutics \/ Morten Mau-Soerensen"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Ida Bruun Kristensen","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2021","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Karyopharm Therapeutics \/ Ida Bruun Kristensen","highestDevelopmentStatusID":"15","companyTruncated":"Karyopharm Therapeutics \/ Ida Bruun Kristensen"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Matthew Ingham","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2019","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase III","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Karyopharm Therapeutics \/ Matthew Ingham","highestDevelopmentStatusID":"10","companyTruncated":"Karyopharm Therapeutics \/ Matthew Ingham"},{"orgOrder":0,"company":"IASO Bio","sponsor":"Chunrui Li","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I","graph3":"IASO Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"IASO Bio \/ Chunrui Li","highestDevelopmentStatusID":"6","companyTruncated":"IASO Bio \/ Chunrui Li"},{"orgOrder":0,"company":"Antengene","sponsor":"Li Zhiming","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Antengene","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Antengene \/ Li Zhiming","highestDevelopmentStatusID":"15","companyTruncated":"Antengene \/ Li Zhiming"},{"orgOrder":0,"company":"Antengene","sponsor":"Xia Zhongjun","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Antengene","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Antengene \/ Xia Zhongjun","highestDevelopmentStatusID":"15","companyTruncated":"Antengene \/ Xia Zhongjun"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Erin Bertino","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2015","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase II","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Karyopharm Therapeutics \/ Erin Bertino","highestDevelopmentStatusID":"8","companyTruncated":"Karyopharm Therapeutics \/ Erin Bertino"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Martin Gutierrez","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Karyopharm Therapeutics \/ Martin Gutierrez","highestDevelopmentStatusID":"7","companyTruncated":"Karyopharm Therapeutics \/ Martin Gutierrez"},{"orgOrder":0,"company":"Antengene","sponsor":"Tong Chen, MD","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2023","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Antengene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Antengene \/ Tong Chen, MD","highestDevelopmentStatusID":"7","companyTruncated":"Antengene \/ Tong Chen, MD"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Kari Kendra","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2014","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase II","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Karyopharm Therapeutics \/ Kari Kendra","highestDevelopmentStatusID":"8","companyTruncated":"Karyopharm Therapeutics \/ Kari Kendra"},{"orgOrder":0,"company":"Karyopharm Therapeutics","sponsor":"Jennifer Woyach","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2014","type":"Inapplicable","leadProduct":"Selinexor","moa":"Exportin-1","graph1":"Oncology","graph2":"Phase I","graph3":"Karyopharm Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Karyopharm Therapeutics \/ Jennifer Woyach","highestDevelopmentStatusID":"6","companyTruncated":"Karyopharm Therapeutics \/ Jennifer Woyach"}]

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                            01

                            Washington University School of Medicine

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                            Washington University School of Medicine

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                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Karyopharm Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma

                            Details : Selinexor is a Cytotoxic Drug drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Multiple Myeloma.

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            September 30, 2025

                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Karyopharm Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Antengene

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                            Antengene

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                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XPOVIO® (Selinexor) Approved in Indonesia, Expanding Antengene's APAC Presence

                            Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of adult patients with multiple myeloma.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            March 04, 2025

                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Karyopharm Therapeutics

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                            Karyopharm Therapeutics

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                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Karyopharm Therapeutics Provides Endometrial Cancer Program Update

                            Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of TP53 wild-type advanced or recurrent endometrial cancer.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Karyopharm Therapeutics

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                            Karyopharm Therapeutics

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                            Lead Product(s) : Selinexor,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Karyopharm Alters Phase 3 SENTRY Trial Endpoint in Myelofibrosis for Favorable Outcome

                            Details : Phase 3 clinical trial evaluating a once-weekly dose of 60mg of Xpovio (selinexor) in combination with twice-daily ruxolitinib in treatment naïve patients with myelofibrosis.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            October 31, 2024

                            Lead Product(s) : Selinexor,Ruxolitinib Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Antengene

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                            Antengene

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                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Antengene Announces XPOVIO® Approved in South Korea For Multiple Myeloma

                            Details : XPOVIO (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            October 17, 2024

                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Antengene

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                            Antengene

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                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Antengene Receives Thailand FDA Approval to Commercialize Xpovio in Thailand

                            Details : Xpovio (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            September 24, 2024

                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Antengene

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                            Antengene

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                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Antengene Announces XPOVIO® (selinexor) Approved for Commercialization in Malaysia

                            Details : XPOVIO® (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            August 05, 2024

                            Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Antengene

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                            Antengene

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                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XPOVIO® Approved for DLBCL in China, Offering New Treatment Option

                            Details : Xpovio (selinexor) is an approved, first-in-class, small molecule, exportin 1 inhibitor. It is given orally to adult patients for the treatment of relapsed/refractory diffuse large B-cell lymphoma.

                            Product Name : Xpovio

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            July 05, 2024

                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            ONCOtherapeutics

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                            ONCOtherapeutics

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                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Trial of Selinexor, Ruxolitinib and Methylprednisolone

                            Details : Selinexor is a Cytotoxic Drug drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Multiple Myeloma.

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            January 25, 2024

                            Lead Product(s) : Selinexor

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Bristol Myers Squibb

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                            Bristol Myers Squibb

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                            Lead Product(s) : Mezigdomide,Selinexor

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Karyopharm Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Karyopharm Announces Clinical Trial Collaboration with Bristol Myers Squibb to Evaluate Novel CELMoD™ Agent ...

                            Details : The collaboratin aims to evaluate the investigational cereblon E3 ligase modulator agent mezigdomide in combination with Karyopharm's selinexor, an approved first-in-class inhibitor of XPO1, plus dexamethasone in patients with relapsed/refractory multipl...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 30, 2023

                            Lead Product(s) : Mezigdomide,Selinexor

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Karyopharm Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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