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Canada","therapeuticArea":"Immunology","highestDevelopmentStatus":"Phase IV","country":"SWITZERLAND","productType":"Large molecule","productStatus":"Biosimilar","date":"May 2024","url1":"","url2":"","graph1":"Immunology","graph2":"Phase IV"},{"orgOrder":0,"company":"Sandoz B2B","sponsor":"Samsung Bioepis","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"FDA approves biosimilar Pyzchiva\u00ae (ustekinumab-ttwe), to be commercialized by Sandoz in US","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Phase IV","country":"SWITZERLAND","productType":"Large molecule","productStatus":"Biosimilar","date":"July 2024","url1":"","url2":"","graph1":"Dermatology","graph2":"Phase IV"},{"orgOrder":0,"company":"Sandoz B2B","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Sandoz Gets EU Approval for Wyost\u00ae and Jubbonti\u00ae Denosumab Biosimilars","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase IV","country":"SWITZERLAND","productType":"Large molecule","productStatus":"Biosimilar","date":"May 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase IV"}]

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            Details:

            Pyzchiva (ustekinumab), is an approved IL-12/IL-23 inhibitor is given once in 12 weeks SC and IV for the treatment of moderate to severe plaque psoriasis in patients with 6 years or older.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: Pyzchiva

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Samsung Bioepis

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 01, 2024

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            Wyost (denosumab) is a human monoclonal antibody and a biosimilar candidate to Prolia & Xgeva. It is a RANK ligand inhibitor, which is approved for patients with bone metastases from solid tumors.

            Lead Product(s): Denosumab

            Therapeutic Area: Oncology Product Name: Wyost

            Highest Development Status: Phase IV Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 22, 2024

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            Rymti (etanercept-biosimilar) is a tumor necrosis factor (TNF) blocker indicated for the treatment of rheumatoid arthritis, polyarticular juvenile idiopathic arthritis in patients aged 2 years or older, psoriatic arthritis, ankylosing spondylitis & plaque psoriasis.

            Lead Product(s): Etanercept

            Therapeutic Area: Immunology Product Name: Rymti

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Lupin Ltd

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 03, 2024

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            Pyzchiva (ustekinumab-biosimilar) is a human IgG1κ monoclonal antibody (mAb) which inhibits IL-12 & Il-23. It is approved by EMA for the treatment of crohn’s disease, psoriasis and psoriatic arthritis.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: Pyzchiva

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Samsung Bioepis

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 22, 2024

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            Wyost (denosumab) is a human monoclonal antibody and a biosimilar candidate to Prolia & Xgeva. It is a RANK ligand inhibitor, which is approved for patients with bone metastases from solid tumors.

            Lead Product(s): Denosumab

            Therapeutic Area: Oncology Product Name: Wyost

            Highest Development Status: Phase IV Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 05, 2024

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            Through the acquisition, Sandoz will access US biosimilar Cimerli (ranibizumab) from Coherus. Currently used in the treatment of Neovascular (Wet) Age-Related Macular Degeneration, Macular Edema Following Retinal Vein Occlusion, Diabetic Macular Edema.

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: Cimerli

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Coherus Biosciences

            Deal Size: $170.0 million Upfront Cash: $170.0 million

            Deal Type: Divestment March 04, 2024

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            The partnership seeks to enhance the commercialization efforts of Ogivri (trastuzumab), an FDA-approved biosimilar product utilized in the treatment of patients diagnosed with breast cancer or metastatic stomach cancer.

            Lead Product(s): Trastuzumab

            Therapeutic Area: Oncology Product Name: Ogivri

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Biocon Biologics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership February 10, 2024

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            Tyruko (natalizumab-sztn - biosimilar) is a highly effective anti-α4 integrin monoclonal antibody. It is indicated for the treatment of relapsing-remitting forms of multiple sclerosis.

            Lead Product(s): Natalizumab

            Therapeutic Area: Neurology Product Name: Tyruko

            Highest Development Status: Phase IV Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 31, 2024

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            Details:

            Through the acquisition, Sandoz will access US biosimilar Cimerli (ranibizumab) from Coherus. Currently used in the treatment of Neovascular (Wet) Age-Related Macular Degeneration, Macular Edema Following Retinal Vein Occlusion, Diabetic Macular Edema.

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: Cimerli

            Highest Development Status: Phase IV Product Type: Large molecule

            Recipient: Coherus Biosciences

            Deal Size: $170.0 million Upfront Cash: $170.0 million

            Deal Type: Divestment January 22, 2024

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            Details:

            The agreements aim to support Aspen for commercialization of Sandostatin LAR Depot (octreotide acetate), which is indicated for long-term treatment of acromegaly & severe diarrhea and flushing episodes associated with metastatic carcinoid tumors.

            Lead Product(s): Octreotide Acetate

            Therapeutic Area: Endocrinology Product Name: Sandostatin LAR Depot

            Highest Development Status: Phase IV Product Type: Peptide

            Partner/Sponsor/Collaborator: Aspen Pharmacare Holdings

            Deal Size: $99.9 million Upfront Cash: Undisclosed

            Deal Type: Agreement December 04, 2023

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