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III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"CG Oncology \/ Kissei Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"CG Oncology \/ Kissei Pharmaceutical"},{"orgOrder":0,"company":"CG Oncology","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"Cretostimogene Grenadenorepvec","moa":"||GM-CSF","graph1":"Oncology","graph2":"Phase III","graph3":"CG Oncology","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"CG Oncology \/ Merck & Co","highestDevelopmentStatusID":"10","companyTruncated":"CG Oncology \/ Merck & Co"},{"orgOrder":0,"company":"University of North Carolina","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Entinostat","moa":"||HDAC","graph1":"Oncology","graph2":"Phase II","graph3":"University of North Carolina","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"University of North Carolina \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"University of North Carolina \/ Inapplicable"},{"orgOrder":0,"company":"Genexine","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SOUTH KOREA","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"GX-188E","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Genexine","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"Genexine \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Genexine \/ Inapplicable"},{"orgOrder":0,"company":"Genexine","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SOUTH KOREA","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"GX-188E","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Genexine","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"Genexine \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Genexine \/ Inapplicable"},{"orgOrder":0,"company":"Genexine","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SOUTH KOREA","productType":"Vaccine","year":"2022","type":"Inapplicable","leadProduct":"GX-188E","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Genexine","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"Genexine \/ Merck & Co","highestDevelopmentStatusID":"8","companyTruncated":"Genexine \/ Merck & Co"},{"orgOrder":0,"company":"Precigen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"Pembrolizumab","moa":"||Immunostimulant","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Precigen","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Precigen \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Precigen \/ Inapplicable"},{"orgOrder":0,"company":"Linnaeus Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"LNS8801","moa":"||GPER","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Linnaeus Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Linnaeus Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Linnaeus Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Pliant Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Pembrolizumab","moa":"||Alpha-5-beta-1\/Alpha-5-beta-8","graph1":"Oncology","graph2":"Phase I","graph3":"Pliant Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Pliant Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Pliant Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"BridgeBio Oncology Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"BBO-11818","moa":"||KRASG12D\/KRASG12V","graph1":"Oncology","graph2":"Phase I","graph3":"BridgeBio Oncology Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"BridgeBio Oncology Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"BridgeBio Oncology Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Toragen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Pembrolizumab","moa":"||E5 oncogene protein","graph1":"Oncology","graph2":"Phase I","graph3":"Toragen","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Toragen \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Toragen \/ Inapplicable"},{"orgOrder":0,"company":"Gilead Sciences","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2025","type":"Inapplicable","leadProduct":"Sacituzumab Govitecan","moa":"||DNA topoisomerase I","graph1":"Oncology","graph2":"Phase III","graph3":"Gilead Sciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Gilead Sciences \/ Merck & Co","highestDevelopmentStatusID":"10","companyTruncated":"Gilead Sciences \/ Merck & Co"},{"orgOrder":0,"company":"ALX Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2025","type":"Inapplicable","leadProduct":"Evorpacept","moa":"||CD47","graph1":"Oncology","graph2":"Phase II","graph3":"ALX Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"ALX Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"ALX Oncology \/ Inapplicable"}]

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                            01

                            Sanofi

                            France
                            BIO International Convention
                            Exhibiting
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

                            Lead Product(s) : AMX-818,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Vir Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Vir Biotech Closes Global License Deal with Sanofi For T-Cell Engagers

                            Details : Through the license agreement, Vir Biotechnology will gain the rights of three clinical-stage masked TCEs, which include SAR446309 (AMX-818) for the treatment of HER2-mutated Breast Neoplasms.

                            Product Name : SAR446309

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            September 09, 2024

                            Lead Product(s) : AMX-818,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Vir Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            02

                            Sanofi

                            France
                            BIO International Convention
                            Exhibiting
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

                            Lead Product(s) : AMX-818,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Vir Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Vir Biotechnology Expands with Worldwide License Agreement with Sanofi for T-cell Engagers

                            Details : Through the license agreement, Vir Biotechnology will gain the rights of three clinical-stage masked TCEs, which include SAR446309 (AMX-818) for the treatment of HER2-mutated Breast Neoplasms.

                            Product Name : SAR446309

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            January 08, 2024

                            Lead Product(s) : AMX-818,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Vir Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            03

                            Gilead Sciences

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Gilead Sciences

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Sacituzumab Govitecan,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Trodelvy Plus Keytruda Improves Survival in PD-L1+ TNBC Patients

                            Details : Trodelvy (sacituzumab govitecan-hziy) a topoisomerase 1 inhibitor plus Keytruda (pembrolizumab) is being investigated in patients with inoperable locally advanced or mTNBC whose tumors express PD-L1.

                            Product Name : Trodelvy

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            April 21, 2025

                            Lead Product(s) : Sacituzumab Govitecan,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Daiichi Sankyo

                            Japan arrow
                            AACR Annual meeting
                            Not Confirmed

                            Daiichi Sankyo

                            Japan arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Trastuzumab Deruxtecan,Cisplatin,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Enhertu Initiated in Patients with Previously Untreated HER2 Positive Gastric Cancer

                            Details : Enhertu (trastuzumab deruxtecan) in combination with fluoropyrimidine chemotherapy, pembrolizumab is being studied for unresectable, locally advanced or metastatic HER2 positive gastric or GEJ cancer.

                            Product Name : Enhertu

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            March 31, 2025

                            Lead Product(s) : Trastuzumab Deruxtecan,Cisplatin,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Actinium pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Actinium pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Ac-225 Lintuzumab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Actinium Combines Actimab-A with KEYTRUDA and OPDIVO in Solid Tumors

                            Details : Actimab-A (Ac225-Lintuzumab) can selectively deplete MDSCs in solid tumors. It is being investigated in combination with pembrolizumab for head and neck squamous cell carcinoma.

                            Product Name : Actimab-A

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 18, 2025

                            Lead Product(s) : Ac-225 Lintuzumab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Adagene Suzhou Limited

                            China arrow
                            AACR Annual meeting
                            Not Confirmed

                            Adagene Suzhou Limited

                            China arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : AMP945,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Adagene Begins Phase 2 Neoadjuvant Muzastotug in CRC

                            Details : ADG126 (muzastotug) is a fully human anti-CTLA-4 SAFEbody. It is under development for metastatic microsatellite-stable colorectal cancer.

                            Product Name : ADG126

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            February 27, 2025

                            Lead Product(s) : AMP945,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Evaxion Biotech

                            Denmark arrow
                            AACR Annual meeting
                            Not Confirmed

                            Evaxion Biotech

                            Denmark arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : EVX-01,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaxion Extends Phase 2 Trial for EVX-01 Cancer Vaccine to Boost Data

                            Details : EVX-01 is a peptide-based personalized cancer vaccine which is being evaluated in combination with pembrolizumab for first-line treatment of patients with advanced melanoma.

                            Product Name : EVX-01

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : EVX-01,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Pyxis Oncology

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Pyxis Oncology

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
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                            • WHO-GMP
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                            Lead Product(s) : PYX-201,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pyxis Starts PYX-201 Combo Trial & Expands Ongoing Monotherapy Study

                            Details : PYX-201 is an antibody-drug conjugate (ADC) with a microtubule inhibitor, being investigated in combination with Merck’s anti-PD-1 therapy, keytruda (pembrolizumab), in patients with R/M HNSCC.

                            Product Name : PYX-201

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            February 04, 2025

                            Lead Product(s) : PYX-201,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Kazia Therapeutics

                            Australia arrow
                            AACR Annual meeting
                            Not Confirmed

                            Kazia Therapeutics

                            Australia arrow
                            AACR Annual meeting
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Paxalisib,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Paxalisib Immunotherapy Combo Study Launched for Breast Cancer

                            Details : GDC-0084 (paxalisib) is a PI3-kinase class I inhibitor, small molecule drug candidate. It is being evaluated in combination with immunotherapy for the treatment of triple negative breast cancer.

                            Product Name : GDC-0084

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 30, 2025

                            Lead Product(s) : Paxalisib,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Personalis

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Personalis

                            U.S.A arrow
                            AACR Annual meeting
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                            • WHO-GMP
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                            Lead Product(s) : mRNA-4157,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Merck & Co

                            Deal Size : $50.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Personalis Gains Merck Investment and Extends Moderna Collaboration

                            Details : Merck will leverage Personalis' advanced tumor profiling platform to support the clinical development of V940 (mRNA-4157), which is currently being evaluated for Stage II/IIIB NSCLC.

                            Product Name : V940

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            December 19, 2024

                            Lead Product(s) : mRNA-4157,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Merck & Co

                            Deal Size : $50.0 million

                            Deal Type : Private Placement

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