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Hoffmann-La Roche","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Roche\u2019s Vabysmo Maintained Vision Improvements with Extended Treatment Intervals up To Four Months for People with Retinal Vein Occlusion (RVO) in Phase III Studies","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase III","country":"SWITZERLAND","productType":"Large molecule","productStatus":"Approved","date":"October 2023","url1":"","url2":"","graph1":"Large molecule","graph2":"F. Hoffmann-La Roche"}]

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            Details:

            Vabysmo (faricimab-svoa) is the first bispecific antibody which targets and inhibits two signalling pathways linked to a number of vision-threatening retinal conditions by neutralising Ang-2 and VEGF-A. It is being investigated for the treatment of retinal vein occlusion.

            Lead Product(s): Faricimab-svoa

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 10, 2023

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            SOK583A1 (aflibercept) is a recombinant fusion protein that bind to vascular endothelial growth factor A (VEGF-A) and placental growth factor (PlGF) used to treat neovascular (wet) age-related macular degeneration (AMD), various types of macular edema and diabetic retinopathy.

            Lead Product(s): Aflibercept

            Therapeutic Area: Ophthalmology Product Name: SOK583A1

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 15, 2023

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            OCS-01 eye drops, a novel, once-daily, high concentration, preservative-free, topical OPTIREACH® formulation of dexamethasone is being developed for the treatment of inflammation and pain following ocular surgery.

            Lead Product(s): Dexamethasone

            Therapeutic Area: Ophthalmology Product Name: OCS-01

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 08, 2023

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            Oculis will fund its development programs in Diabetic Macular Edema and other ophthalmic indications, including OCS-01's NDA enabling activities. OCS-01 (dexamethasone) eye drops is developed using the Optireach® solubilizing technology for the treatment of DME.

            Lead Product(s): Dexamethasone

            Therapeutic Area: Ophthalmology Product Name: OCS-01

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: BofA Securities

            Deal Size: $40.2 million Upfront Cash: Undisclosed

            Deal Type: Public Offering May 31, 2023

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            OCS-01 (dexamethasone) has been developed using the OPTIREACH solubilizing nanoparticle technology, enabing the formulation of drugs as non-invasive topical treatments, a longer residence time on the eye surface and enhances their bioavailability in the relevant eye tissues.

            Lead Product(s): Dexamethasone

            Therapeutic Area: Ophthalmology Product Name: OCS-01

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 22, 2023

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            Details:

            Vabysmo (faricimab-svoa) is the first bispecific antibody which targets and inhibits two signalling pathways linked to a number of vision-threatening retinal conditions by neutralising Ang-2 and VEGF-A. It is being investigated for the treatment of retinal vein occlusion.

            Lead Product(s): Faricimab-svoa

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 09, 2023

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            Details:

            OCS-01 (dexamethasone) has been developed using the OPTIREACH solubilizing nanoparticle technology, enabing the formulation of drugs as non-invasive topical treatments, a longer residence time on the eye surface and enhances their bioavailability in the relevant eye tissues.

            Lead Product(s): Dexamethasone

            Therapeutic Area: Ophthalmology Product Name: OCS-01

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 16, 2023

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            Details:

            Vabysmo (faricimab) is the first bispecific antibody approved for the eye. It targets and inhibits two signalling pathways linked to a number of vision-threatening retinal conditions by neutralising angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A).

            Lead Product(s): Faricimab-svoa

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 10, 2023

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            Details:

            OCS-01 (Dexamethasone) has been developed using the OPTIREACH solubilizing nanoparticle technology, enabing the formulation of drugs as non-invasive topical treatments, a longer residence time on the eye surface and enhances their bioavailability in the relevant eye tissues.

            Lead Product(s): Dexamethasone

            Therapeutic Area: Ophthalmology Product Name: OCS-01

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 04, 2023

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            Details:

            Vabysmo® (faricimab) is first bispecific antibody approved for eye targets and inhibits two disease pathways linked to a number of vision-threatening retinal conditions by neutralising angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A).

            Lead Product(s): Faricimab-svoa

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 27, 2022

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