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Molecule","year":"2025","type":"Acquisition","leadProduct":"STC-004","moa":"NaV1.8 Channel","graph1":"Neurology","graph2":"Phase I","graph3":"SiteOne Therapeutics","amount2":1,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":1,"dosageForm":"Oral Suspension","sponsorNew":"SiteOne Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"6","companyTruncated":"SiteOne Therapeutics \/ Eli Lilly"},{"orgOrder":0,"company":"GRIN Therapeutics","sponsor":"Angelini Pharma","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Collaboration","leadProduct":"Radiprodil","moa":"NMDA receptor","graph1":"Neurology","graph2":"Phase I","graph3":"GRIN Therapeutics","amount2":0.56999999999999995,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0.56999999999999995,"dosageForm":"Oral Suspension","sponsorNew":"GRIN Therapeutics \/ Angelini Pharma","highestDevelopmentStatusID":"6","companyTruncated":"GRIN Therapeutics \/ Angelini Pharma"},{"orgOrder":0,"company":"Vima Therapeutics","sponsor":"Atlas Venture","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Series A Financing","leadProduct":"VIM0423","moa":"mAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Vima Therapeutics","amount2":0.059999999999999998,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0.059999999999999998,"dosageForm":"Undisclosed","sponsorNew":"Vima Therapeutics \/ Atlas Venture","highestDevelopmentStatusID":"6","companyTruncated":"Vima Therapeutics \/ Atlas Venture"},{"orgOrder":0,"company":"Stalicla","sponsor":"Addex Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2025","type":"Financing","leadProduct":"Ibudilast","moa":"||PDE4\/3","graph1":"Neurology","graph2":"Phase I","graph3":"Stalicla","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Stalicla \/ Addex Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Stalicla \/ Addex Therapeutics"}]

    Find Neurology Drugs in Phase I Clinical Development in UNITED STATES

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                            01

                            Orion Corporation

                            Finland
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : ODM-111

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Orion Terminates ODM-111 Program Due To Narrow Therapeutic Window Challenges

                            Details : ODM-111 is NaV. 1.8 blocker was being evaluated in the early-stage clinical trial studies with the patients for the treatment of acute and chronic pain.

                            Product Name : ODM-111

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 24, 2024

                            Lead Product(s) : ODM-111

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Veranova

                            U.S.A
                            ChemOutsourcing
                            Attending
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothVeranova: A CDMO that manages complexity with confidence.

                            Lead Product(s) : Fentanyl

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Nutriband

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Nutriband Licenses Bitrex for AVERSA Fentanyl Transdermal Patch

                            Details : Nutriband signs licensing agreement for Bitrex (denatonium benzoate) as an aversive agent for its Aversa Fentanyl (Fentanyl) abuse deterrent fentanyl transdermal patch.

                            Product Name : Aversa

                            Product Type : Controlled Substance

                            Upfront Cash : Undisclosed

                            September 20, 2024

                            Lead Product(s) : Fentanyl

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Nutriband

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            Veranova

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                            03

                            Quotient Sciences

                            United Kingdom
                            ChemOutsourcing
                            Attending
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothQuotient Sciences- Molecule to Cure. Fast.

                            Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Ensysce Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Ensysce Advances Overdose Protection Platform in Clinical Development

                            Details : The collaboration aims to examine and evaluate the full commercial dose range of the PF614-MPAR drug product, the combination of PF614 with the trypsin inhibitor nafamostat, to treat chronic pain.

                            Product Name : PF614-MPAR

                            Product Type : Controlled Substance

                            Upfront Cash : Undisclosed

                            May 20, 2024

                            Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Ensysce Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            Quotient

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                            04

                            Quotient Sciences

                            United Kingdom
                            ChemOutsourcing
                            Attending
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothQuotient Sciences- Molecule to Cure. Fast.

                            Lead Product(s) : Oxycodone Prodrug,Nafamostat

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Ensysce Biosciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ensysce Biosciences' PF614-MPAR Enters Final Stage of Phase 1 Study

                            Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...

                            Product Name : PF614-MPAR

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            January 25, 2023

                            Lead Product(s) : Oxycodone Prodrug,Nafamostat

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Ensysce Biosciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            Quotient

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                            05

                            AbbVie Inc

                            U.S.A
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Fosigotifator

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Massachusetts General Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Investigational Drug ABBV-CLS-7262 Initiates Design Phase For Entry Into The HEALEY ALS Platform Trial

                            Details : ABBV-CLS-7262 targets eIF2B, a key regulator of the ISR, a pathway activated in people with ALS. In neurons exposed to cellular stressors, inhibition of the ISR by ABBV-CLS-7262 restores protein synthesis and dissolves pre-formed TDP-43 containing stress...

                            Product Name : ABBV-CLS-7262

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 07, 2022

                            Lead Product(s) : Fosigotifator

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Massachusetts General Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            Abbvie Company Banner

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                            06

                            Quotient Sciences

                            United Kingdom
                            ChemOutsourcing
                            Attending
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothQuotient Sciences- Molecule to Cure. Fast.

                            Lead Product(s) : Buprenorphine

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Emplicure

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Emplicure AB and Quotient Sciences Announce an Integrated Manufacturing and Clinical Testing Partnership for E...

                            Details : Under the partnership, Quotient Sciences will support the GMP manufacture and first clinical pharmacokinetic (PK) study for EMPLI03 (buprenorphine) using its unique Translational Pharmaceutics® platform for the treatment of moderate to severe pain.

                            Product Name : Empli03

                            Product Type : Controlled Substance

                            Upfront Cash : Undisclosed

                            November 29, 2022

                            Lead Product(s) : Buprenorphine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Emplicure

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            Quotient

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                            07

                            Stalicla

                            Switzerland arrow
                            APGA Annual Conference
                            Not Confirmed

                            Stalicla

                            Switzerland arrow
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Ibudilast,Bumetanide

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Addex Therapeutics

                            Deal Size : $2.5 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Addex Leads CHF 2 Million Investment in Stalicla to Advance Precision Medicine

                            Details : Stalicla will use the financing to advance its portfolio of autism focused drug candidates, including STP1, a fixed dose combination of PDE4/3 inhibitor (ibudilast) and NKCC1 antagonist (bumetanide).

                            Product Name : STP1

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 30, 2025

                            Lead Product(s) : Ibudilast,Bumetanide

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Addex Therapeutics

                            Deal Size : $2.5 million

                            Deal Type : Financing

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                            08

                            Vima Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed

                            Vima Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : VIM0423

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Atlas Venture

                            Deal Size : $60.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            Vima Therapeutics Launches First Oral Therapy for Dystonia and Movement Disorders

                            Details : Vima is advancing VIM0423, a potential first-in-class oral therapy for dystonia that targets the underlying cause in the central nervous system.

                            Product Name : VIM0423

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            May 29, 2025

                            Lead Product(s) : VIM0423

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Atlas Venture

                            Deal Size : $60.0 million

                            Deal Type : Series A Financing

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                            09

                            SiteOne Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed

                            SiteOne Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : STC-004

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,000.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Lilly to Expand its Pain Pipeline with Acquisition of SiteOne Therapeutics

                            Details : The acquisition of SiteOne Therapeutics includes STC-004, a next-generation, Phase 2 ready Nav1.8 inhibitor being studied as non-opioid treatment for patients suffering from chronic pain.

                            Product Name : STC-004

                            Product Type : Other Small Molecule

                            Upfront Cash : $1,000.0 million

                            May 27, 2025

                            Lead Product(s) : STC-004

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,000.0 million

                            Deal Type : Acquisition

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                            10

                            GRIN Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed

                            GRIN Therapeutics

                            U.S.A arrow
                            APGA Annual Conference
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Angelini Pharma

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            GRIN and Angelini Partner to Develop Radiprodil Globally Except North America

                            Details : Angelini Pharma will receive exclusive rights to commercialize radiprodil, currently being studied in multiple rare genetic epilepsies and neurodevelopmental disorders, outside north america.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : $50.0 million

                            May 27, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Angelini Pharma

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

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