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Lead Product(s): PF-05251749
Therapeutic Area: Neurology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Biogen
Deal Size: $710.0 million Upfront Cash: $75.0 million
Deal Type: Acquisition January 13, 2020
Details:
With this purchase, Biogen plans to develop the Phase 1 asset for the treatment of Sundowning in Alzheimer’s disease (AD) and Irregular Sleep Wake Rhythm Disorder in Parkinson’s disease.
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Lead Product(s): LP352
Therapeutic Area: Neurology Product Name: LP352
Highest Development Status: Phase I Product Type: Undisclosed
Partner/Sponsor/Collaborator: Arena Pharmaceuticals
Deal Size: $56.0 million Upfront Cash: Undisclosed
Deal Type: Financing October 28, 2020
Details:
Proceeds from the financing will be used to support the development of LP352 for treatment-resistant developmental and epileptic encephalopathies, and preclinical programs relating to LP143 and LP659 for the potential treatment of microglial neuroinflammatory diseases.
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Lead Product(s): Leronlimab
Therapeutic Area: Neurology Product Name: PRO 140
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 26, 2020
Details:
Company is accelerating the filing of a Ph2 protocol to evaluate leronlimab’s potential as a therapeutic for stroke recovery. Administration of leronlimab resulted in approx. 70-75% CCR5 receptor occupancy in the Brain.
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Lead Product(s): Diazepam
Therapeutic Area: Neurology Product Name: XP-0863
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 20, 2020
Details:
The FDA provided feedback that Xeris’ drug development program for XP-0863 could advance directly into a Phase 3 registration study in both pediatric and adult patients with epilepsy.
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Lead Product(s): NBI-921352
Therapeutic Area: Neurology Product Name: XEN901
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Xenon Pharmaceuticals Inc
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 08, 2020
Details:
U.S. Food and Drug Administration (FDA) Requests Additional Non-Clinical Data to Support Dose Justification Before Initiation of a Phase II Clinical Trial with NBI-921352 in Pediatric SCN8A-DEE Patients.
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Lead Product(s): DNL151
Therapeutic Area: Neurology Product Name: DNL151
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Biogen
Deal Size: $2,150.0 million Upfront Cash: $560.0 million
Deal Type: Licensing Agreement October 07, 2020
Details:
The companies will co-develop Denali’s small molecule inhibitors of leucine-rich repeat kinase 2 (LRRK2) for Parkinson’s disease, and will co-commercialize Denali’s LRRK2 products in the United States and China, with shared responsibility for worldwide development costs.
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Lead Product(s): KCP-506
Therapeutic Area: Neurology Product Name: KCP-506
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Genentech
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration October 07, 2020
Details:
With the extension, Kineta will continue development of α9/α10 nicotinic acetylcholine receptor (nAChR) antagonists and will advance KCP506 through Phase 1 clinical trials. Kineta will also receive an undisclosed payment from Genentech to extend the research collaboration.
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Lead Product(s): XPro1595
Therapeutic Area: Neurology Product Name: XPro1595
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 05, 2020
Details:
The preliminary data, albeit in a small number of patients, demonstrate that XPro1595, when given via subcutaneous injection, decreases neuroinflammation in the arcuate fasciculus.
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Lead Product(s): Resveratrol
Therapeutic Area: Neurology Product Name: Jotrol
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 01, 2020
Details:
The U.S. patent covers the suspension of active ingredient resveratrol and other compounds in a micellar emulsion that can be delivered via oral capsule.
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Lead Product(s): Resveratrol
Therapeutic Area: Neurology Product Name: Jotrol
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: National Institutes of Health
Deal Size: $1.7 million Upfront Cash: Undisclosed
Deal Type: Funding September 22, 2020
Details:
The company's lead candidate, IMC-1, is a novel combination antiviral therapy designed to synergistically suppress Herpes Simplex Virus-1activation and replication, with the end goal of reducing viral mediated disease burden.
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