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                          Top Deals by Deal Size (USD bn)

                          01

                          BioProcess International Europe
                          Not Confirmed
                          BioProcess International Europe
                          Not Confirmed

                          Details : The award will support the clinical validation of the Company’s lead candidate, microRNA candidate INT-1B3, for the treatment of solid tumors.

                          Product Name : INT-1B3

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          November 03, 2021

                          Lead Product(s) : INT-1B3

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Dutch Government

                          Deal Size : $3.2 million

                          Deal Type : Funding

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                          02

                          BioProcess International Europe
                          Not Confirmed
                          BioProcess International Europe
                          Not Confirmed

                          Details : The published results include data from tumor cell lines and experimental tumor models and support the high therapeutic potential of INT-1B3 in solid tumor indications.

                          Product Name : INT-1B3

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          March 24, 2021

                          Lead Product(s) : INT-1B3

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BioProcess International Europe
                          Not Confirmed
                          BioProcess International Europe
                          Not Confirmed

                          Details : INT-1B3 is a microRNA-mimic of the endogenous tumour suppressor miR-193a-3p formulated in next-generation lipid nanoparticles and can potentially address various hallmarks of cancer at the same time.

                          Product Name : INT-1B3

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 16, 2021

                          Lead Product(s) : INT-1B3

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          BioProcess International Europe
                          Not Confirmed
                          BioProcess International Europe
                          Not Confirmed

                          Details : First-in-human trial will test the safety, pharmacokinetics and preliminary efficacy of microRNA therapeutic candidate INT-1B3.

                          Product Name : INT-1B3

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 05, 2020

                          Lead Product(s) : INT-1B3

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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