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Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cytovia Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Cytovia Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Cytovia Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"CYT-101","moa":"Dual EGFR","graph1":"Oncology","graph2":"Preclinical","graph3":"Cytovia Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cytovia Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Cytovia Therapeutics \/ Inapplicable"}]

Find Oncology Clinical Drug Pipeline Developments & Deals by Cytovia Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activation receptor NKp46.

                          Product Name : CYT-338

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 27, 2022

                          Lead Product(s) : CYT-338

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activating receptor NKp46.

                          Product Name : CYT-338

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 06, 2022

                          Lead Product(s) : CYT-338

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : First in vivo data demonstrated anti-tumor activity of Glypican-3 (GPC3) Flex-NK™ cell engager CYT-303 in combination with iNK cells in an animal model of Hepatocellular carcinoma (HCC).

                          Product Name : CYT-303

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          August 04, 2022

                          Lead Product(s) : CYT-303,iNK Cell

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : In addition, CYT-503, a GPC3-targeting CAR-iNK cell therapeutic, is designed to improve specificity for tumor targeting. Cytovia expects to file INDs for CYT-303 and CYT-100, followed by INDs for CYT-150 and CYT-503.

                          Product Name : CYT-303

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          April 26, 2022

                          Lead Product(s) : CYT-303,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Isleworth Healthcare Acquisition Corp.

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          05

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : CYT 303 is a FLEX-NK® tetravalent bispecific trifunctional antibody targeting GPC3, a glycoprotein highly expressed on solid tumors, including Hepatocellular carcinoma, but not on adult healthy cells, is being developed to treat solid tumors expressing ...

                          Product Name : CYT-303

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 16, 2022

                          Lead Product(s) : CYT-303

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : TF Capital, a leading China-based biotech institutional investor and Cytovia have formed CytoLynx Therapeutics, and invests to finance the IND enabling and initial clinical development of the pipeline programs including CYT-303.

                          Product Name : CYT-303

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 13, 2021

                          Lead Product(s) : CYT-303

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : TF Capital

                          Deal Size : $45.0 million

                          Deal Type : Financing

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                          07

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : CytoLynx obtained a technology license from Cytovia based on its core technologies to allow in-China development of additional NK therapeutics for global commercialization including CYT-100.

                          Product Name : CYT-100

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $400.0 million

                          September 13, 2021

                          Lead Product(s) : CYT-100

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : CytoLynx

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : Cytovia has signed a licensing agreement with the National Cancer Institute (NCI), part of the National Institutes of Health, to apply its gene-edited iPSC-derived NK cell technology to develop GPC3 CAR NK cell therapeutics.

                          Product Name : CYT-503

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 13, 2021

                          Lead Product(s) : CYT-503

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : National Institutes of Health

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          09

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : The use of iPSC-NK cells constitutes a transformational approach to cancer treatment, enabling the use of precision cell therapy for many patients. Cytovia plans to initiate first clinical trials with iPSC NK-cells in 2021.

                          Product Name : CYT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          August 25, 2020

                          Lead Product(s) : CYT-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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