Company profile for Cytovia Therapeutics

NEW Drugs in Dev: 6
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About

Cytovia aims to accelerate patient access to transformational cell therapies and immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia primarily focuses on Natural Killer (NK) cell biology and applies precision medicine tools to develop the right therapy for the right patient at the right stage of the disease. Cytovia has secured access to multip...
Cytovia aims to accelerate patient access to transformational cell therapies and immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia primarily focuses on Natural Killer (NK) cell biology and applies precision medicine tools to develop the right therapy for the right patient at the right stage of the disease. Cytovia has secured access to multiple advanced technologies, including an induced pluripotent stem cell (iPSC) platform for NK cell therapy, gene editing of Chimeric Antigen Receptors (CAR) to enhance targeting of NK cells.

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CONTACT DETAILS

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U.S.A
Address
Address
Brickell Bayview Center 80 SW 8th Street Suite 2000 Miami, FL 33130
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Telephone
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NEWS #PharmaBuzz

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https://www.prnewswire.com/news-releases/cytovia-therapeutics-presents-new-data-on-cd38-targeted-flex-nk-bispecific-antibody-at-2022-american-society-of-hematology-annual-meeting-301698987.html

PRNEWSWIRE
09 Dec 2022

https://bionj.org/news/pr-newswire-global?rkey=20221209FL60813&filter=16221

BIONJ
09 Dec 2022

https://www.prnewswire.com/news-releases/cytovia-therapeutics-presents-new-data-on-talen-gene-edited-ink-cells-and-gpc3-targeted-flex-nk-bispecific-antibodies-at-2022-sitc-annual-meeting-301669887.html

PRNEWSWIRE
07 Nov 2022

https://www.prnewswire.com/news-releases/cytovia-therapeutics-to-present-new-data-on-cd38-flex-nk-cell-engager-bispecific-antibodies-for-multiple-myeloma-at-2022-ash-annual-meeting-301661737.html

PRNEWSWIRE
27 Oct 2022

https://www.prnewswire.com/news-releases/cytovia-therapeutics-presents-new-preclinical-data-for-its-gpc3-flex-nk-cell-engager-antibody-in-combination-with-natural-killer-cells-at-esmo-2022-in-paris-301621698.html

PRNEWSWIRE
12 Sep 2022

https://www.prnewswire.com/news-releases/cytovia-therapeutics-presents-antitumor-activity-of-its-cd38-targeting-flex-nk-cell-engager-antibody-at-eha-2022-congress-301565565.html

PRNEWSWIRE
10 Jun 2022

Drugs in Development

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Details:

Under the partnership, Cytovia will be responsible for the differentiation and expansion of the gene-edited iPSC-derived NK Cells and will conduct the pre-clinical evaluation, clinical development, and commercialization of the selected therapeutic candidates.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Undisclosed

Recipient: Cellectis

Deal Size: $825.0 million Upfront Cash: $20.0 million

Deal Type: Collaboration January 20, 2023

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Details : Under the partnership, Cytovia will be responsible for the differentiation and expansion of the gene-edited iPSC-derived NK Cells and will conduct the pre-clinical evaluation, clinical development, and commercialization of the selected therapeutic candid...

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : $20.0 million

January 20, 2023

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Details:

CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activation receptor NKp46.


Lead Product(s): CYT-338

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 27, 2022

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VMX
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Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activation receptor NKp46.

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Inapplicable

October 27, 2022

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Details:

CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activating receptor NKp46.


Lead Product(s): CYT-338

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 10, 2022

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VMX
Not Confirmed
VMX
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Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activating receptor NKp46.

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Inapplicable

June 10, 2022

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Details:

Cellectis has granted Cytovia a worldwide license under the patent rights over which Cellectis has control in this field, including in China, in order for Cytovia to modify NK cells to address multiple gene-targets for therapeutic use in several cancer indications.


Lead Product(s): CYT-303,Undisclosed

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Recipient: Cellectis

Deal Size: $825.0 million Upfront Cash: $20.0 million

Deal Type: Collaboration April 27, 2022

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VMX
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Details : Cellectis has granted Cytovia a worldwide license under the patent rights over which Cellectis has control in this field, including in China, in order for Cytovia to modify NK cells to address multiple gene-targets for therapeutic use in several cancer i...

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : $20.0 million

April 27, 2022

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Details:

In addition, CYT-503, a GPC3-targeting CAR-iNK cell therapeutic, is designed to improve specificity for tumor targeting. Cytovia expects to file INDs for CYT-303 and CYT-100, followed by INDs for CYT-150 and CYT-503.


Lead Product(s): CYT-303,Undisclosed

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: Isleworth Healthcare Acquisition Corp.

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Merger April 26, 2022

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Lead Product(s) : CYT-303,Undisclosed

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Partner/Sponsor/Collaborator : Isleworth Healthcare Acquisition Corp.

Deal Size : Undisclosed

Deal Type : Merger

Details : In addition, CYT-503, a GPC3-targeting CAR-iNK cell therapeutic, is designed to improve specificity for tumor targeting. Cytovia expects to file INDs for CYT-303 and CYT-100, followed by INDs for CYT-150 and CYT-503.

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Undisclosed

April 26, 2022

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Details:

First in vivo data demonstrated anti-tumor activity of Glypican-3 (GPC3) Flex-NKâ„¢ cell engager CYT-303 in combination with iNK cells in an animal model of Hepatocellular carcinoma (HCC).


Lead Product(s): CYT-303,iNK Cell

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 08, 2022

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Lead Product(s) : CYT-303,iNK Cell

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : First in vivo data demonstrated anti-tumor activity of Glypican-3 (GPC3) Flex-NKâ„¢ cell engager CYT-303 in combination with iNK cells in an animal model of Hepatocellular carcinoma (HCC).

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Inapplicable

April 08, 2022

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Details:

CYT 303 is a FLEX-NK® tetravalent bispecific trifunctional antibody targeting GPC3, a glycoprotein highly expressed on solid tumors, including Hepatocellular carcinoma, but not on adult healthy cells, is being developed to treat solid tumors expressing GPC3, including HCC.


Lead Product(s): CYT-303

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 16, 2022

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07

VMX
Not Confirmed
VMX
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Details : CYT 303 is a FLEX-NK® tetravalent bispecific trifunctional antibody targeting GPC3, a glycoprotein highly expressed on solid tumors, including Hepatocellular carcinoma, but not on adult healthy cells, is being developed to treat solid tumors expressing ...

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Inapplicable

March 16, 2022

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Details:

Cellectis is granting Cytovia a worldwide license under the patent rights over which Cellectis has the control in this field, including in China, enabling Cytovia to modify NK cells to address multiple gene-targets for therapeutic use in several cancer indications.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Undisclosed

Recipient: Cellectis

Deal Size: $825.0 million Upfront Cash: Undisclosed

Deal Type: Collaboration November 18, 2021

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08

VMX
Not Confirmed
VMX
Not Confirmed

Details : Cellectis is granting Cytovia a worldwide license under the patent rights over which Cellectis has the control in this field, including in China, enabling Cytovia to modify NK cells to address multiple gene-targets for therapeutic use in several cancer i...

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Undisclosed

November 18, 2021

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Details:

TF Capital, a leading China-based biotech institutional investor and Cytovia have formed CytoLynx Therapeutics, and invests to finance the IND enabling and initial clinical development of the pipeline programs including CYT-303.


Lead Product(s): CYT-303

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: TF Capital

Deal Size: $45.0 million Upfront Cash: Undisclosed

Deal Type: Financing September 13, 2021

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VMX
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Details : TF Capital, a leading China-based biotech institutional investor and Cytovia have formed CytoLynx Therapeutics, and invests to finance the IND enabling and initial clinical development of the pipeline programs including CYT-303.

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : Undisclosed

September 13, 2021

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Details:

CytoLynx obtained a technology license from Cytovia based on its core technologies to allow in-China development of additional NK therapeutics for global commercialization including CYT-100.


Lead Product(s): CYT-100

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Cell & Gene Therapy

Sponsor: CytoLynx

Deal Size: Undisclosed Upfront Cash: $400.0 million

Deal Type: Collaboration September 13, 2021

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10

VMX
Not Confirmed
VMX
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Details : CytoLynx obtained a technology license from Cytovia based on its core technologies to allow in-China development of additional NK therapeutics for global commercialization including CYT-100.

Product Name : Undisclosed

Product Type : Cell & Gene Therapy

Upfront Cash : $400.0 million

September 13, 2021

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