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                            price-trend All Developments

                            Therapeutic Area by Lead Product

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                            Top Deals by Deal Size (USD bn)

                            01

                            Alnylam Pharmaceuticals

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                            Alnylam Pharmaceuticals

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                            Lead Product(s) : ALN-5288

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Regeneron Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

                            Details : ALN-5288 is a Oligonucleotide drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Alzheimer Disease.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            October 09, 2025

                            Lead Product(s) : ALN-5288

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Regeneron Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Alnylam Pharmaceuticals

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                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Not Confirmed
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                            Lead Product(s) : Zilebesiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular...

                            Details : Zilebesiran is a Oligonucleotide drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Cardiovascular Diseases.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            September 18, 2025

                            Lead Product(s) : Zilebesiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Technology

                            Study Phase : Discovery Platform

                            Recipient : Scenic Biotech

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Scenic Enters License and Research Agreement with Alnylam

                            Details : Scenic Biotech license and research agreement with Alnylam to leverage Scenic's Cell-Seq platform for discovering novel targets for RNAi therapeutics.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            August 26, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Technology

                            Highest Development Status : Discovery Platform

                            Recipient : Scenic Biotech

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            04

                            Alnylam Pharmaceuticals

                            U.S.A arrow
                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed
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                            Lead Product(s) : Nucresiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            TRITON-CM: Nucresiran in Patients with Transthyretin Amyloidosis & Cardiomyopathy

                            Details : Nucresiran is a Other Large Molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Transthyretin Amyloidosis with Cardiomyopathy.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            July 08, 2025

                            Lead Product(s) : Nucresiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Alnylam Pharmaceuticals

                            U.S.A arrow
                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Not Confirmed
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                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alnylam gets EC Nod for AMVUTTRA to Treat ATTR Amyloidosis with Cardiomyopathy

                            Details : Amvuttra (vutrisiran sodium) is a double-stranded siRNA-GalNAc conjugate that causes degradation of mutant and wild-type TTR mRNA, in patients with ATTR-CM.

                            Product Name : Amvuttra

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            June 09, 2025

                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Not Confirmed
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                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alnylam Gets CHMP Nod for Vutrisiran to Treat ATTR Cardiomyopathy

                            Details : Amvuttra (vutrisiran) is an investigational RNAi therapeutic, now approved by FDA for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM) in adults.

                            Product Name : Amvuttra

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            April 28, 2025

                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed
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                            Lead Product(s) : Fitusiran

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Approves Qfitlia (fitusiran), First siRNA for Hemophilia A or B Treatment

                            Details : Qfitlia (fitusiran) is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with hemophilia A or B.

                            Product Name : Qfitlia

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 28, 2025

                            Lead Product(s) : Fitusiran

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Alnylam Pharmaceuticals

                            U.S.A arrow
                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed
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                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alnylam’s AMVUTTRA® FDA Approved for Cardiomyopathy in ATTR Amyloidosis

                            Details : Amvuttra (vutrisiran) is an investigational RNAi therapeutic, now approved by FDA for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM) in adults.

                            Product Name : Amvuttra

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 20, 2025

                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Not Confirmed
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                            Lead Product(s) : ALN-4324

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 1 Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers

                            Details : ALN-4324 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Obesity.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : ALN-4324

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Alnylam Pharmaceuticals

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                            SupplySide West
                            Not Confirmed

                            Alnylam Pharmaceuticals

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                            Not Confirmed
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                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alnylam’s Vutrisiran sNDA Accepted by FDA for ATTR Amyloidosis Cardiomyopathy

                            Details : Amvuttra (vutrisiran) is an investigational RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM).

                            Product Name : Amvuttra

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            November 25, 2024

                            Lead Product(s) : Vutrisiran Sodium

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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