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    [{"orgOrder":0,"company":"Cedars-Sinai","sponsor":"Jarrow Formulas","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Catechol O-methyltransferase; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; Arsenite methyltransferase; Glycine N-methyltransferase; S-adenosylmethionine decarboxylase proenzyme; S-adenosylmethionine synthase isoform type-2; Cystathionine beta-synthase; S-adenosylmethionine synthase isoform type-1","graph1":"Oncology","graph2":"Phase II","graph3":"Cedars-Sinai","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cedars-Sinai \/ Jarrow Formulas","highestDevelopmentStatusID":"8","companyTruncated":"Cedars-Sinai \/ Jarrow Formulas"},{"orgOrder":0,"company":"Zhejiang Hisun Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"CHINA","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2013","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Methionine metabolism","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase IV","graph3":"Zhejiang Hisun Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Zhejiang Hisun Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Zhejiang Hisun Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Zhejiang Hisun Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"CHINA","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2013","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Methionine metabolism","graph1":"Infections and Infectious Diseases","graph2":"Phase IV","graph3":"Zhejiang Hisun Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Zhejiang Hisun Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Zhejiang Hisun Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"MSI Methylation Sciences Inc","sponsor":"Algorithme Pharma Inc.","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"CANADA","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2020","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Methionine metabolism","graph1":"Psychiatry\/Psychology","graph2":"Phase I","graph3":"MSI Methylation Sciences Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MSI Methylation Sciences Inc \/ Algorithme Pharma Inc.","highestDevelopmentStatusID":"6","companyTruncated":"MSI Methylation Sciences Inc \/ Algorithme Pharma Inc."},{"orgOrder":0,"company":"Abbott Laboratories","sponsor":"Ascent | Datamap | ClinIntel | Catalent Pharma Solutions","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2014","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Methionine metabolism","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Abbott Laboratories","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Abbott Laboratories \/ Ascent | Datamap | ClinIntel | Catalent Pharma Solutions","highestDevelopmentStatusID":"10","companyTruncated":"Abbott Laboratories \/ Ascent | Datamap | ClinIntel | Catalent Pharma Solutions"},{"orgOrder":0,"company":"Beijing Insight Science & Technology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2017","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Undisclosed","graph1":"Oncology","graph2":"Undisclosed","graph3":"Beijing Insight Science & Technology","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Beijing Insight Science & Technology \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"Beijing Insight Science & Technology \/ Undisclosed"},{"orgOrder":0,"company":"Nutrilinea","sponsor":"Hippocrates Research","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"FRANCE","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2019","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Undisclosed","graph1":"Psychiatry\/Psychology","graph2":"Undisclosed","graph3":"Nutrilinea","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Nutrilinea \/ Hippocrates Research","highestDevelopmentStatusID":"1","companyTruncated":"Nutrilinea \/ Hippocrates Research"},{"orgOrder":0,"company":"Abbott Laboratories","sponsor":"PPD","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Plant Extract\/Herbal","year":"2012","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Abbott Laboratories","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Abbott Laboratories \/ PPD","highestDevelopmentStatusID":"10","companyTruncated":"Abbott Laboratories \/ PPD"}]

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    Ademetionine

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                            01

                            Cedars-Sinai

                            U.S.A arrow
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                            Cedars-Sinai

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Jarrow Formulas

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SAMe in Prevention of Oxaliplatin-associated Liver Injury

                            Details : S-Adenosylmethionine is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Colorectal Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 14, 2024

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Jarrow Formulas

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            MSI Methylation Sciences Inc

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                            AIChE Annual Meeting
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                            MSI Methylation Sciences Inc

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase I

                            Sponsor : Algorithme Pharma Inc.

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionine

                            Details : Ademethionine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Depressive Disorder, Major.

                            Product Name : Undisclosed

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            November 10, 2020

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase I

                            Sponsor : Algorithme Pharma Inc.

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Nutrilinea

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                            Nutrilinea

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Undisclosed

                            Sponsor : Hippocrates Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            EVALUATION OF EFFICACY OF SAMEUP IN SUBJECTS WITH DEPRESSION SYMPTOMS: A RANDOMIZED STUDY

                            Details : SAMEUp (S-Adenosyl Methionine) is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in clinical studies for the treatment of Depression.

                            Product Name : SAMEUp

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            April 30, 2019

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Undisclosed

                            Sponsor : Hippocrates Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Beijing Insight Science & Technology

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                            AIChE Annual Meeting
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                            Beijing Insight Science & Technology

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma

                            Details : S-Adenosyl Methionine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in clinical studies for the treatment of Carcinoma, Hepatocellular.

                            Product Name : Undisclosed

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            June 07, 2017

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Abbott Laboratories

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                            Abbott Laboratories

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Ascent | Datamap | ClinIntel | Catalent Pharma Solutions

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption

                            Details : Ademethionine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Cholestasis, Intrahepatic, Liver Diseases, Alcoholic.

                            Product Name : Undisclosed

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            July 25, 2014

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Ascent | Datamap | ClinIntel | Catalent Pharma Solutions

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Zhejiang Hisun Pharmaceutical

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                            Zhejiang Hisun Pharmaceutical

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis

                            Details : Ademethionine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Hepatitis, Alcoholic.

                            Product Name : Undisclosed

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            December 31, 2013

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Zhejiang Hisun Pharmaceutical

                            China arrow
                            AIChE Annual Meeting
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                            Zhejiang Hisun Pharmaceutical

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis

                            Details : Ademethionine is a Vitamins/Minerals/Inorganic Salts drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Hepatitis B.

                            Product Name : Undisclosed

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            December 02, 2013

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Abbott Laboratories

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                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : PPD

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Investigate the Effects of Different Doses of S-adenosyl-L-methionine (SAMe) in Subjects With Nonalco...

                            Details : S-Adenosyl-L-Methionine is a Plant Extract/Herbal drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Non-alcoholic Fatty Liver Disease.

                            Product Name : Undisclosed

                            Product Type : Plant Extract/Herbal

                            Upfront Cash : Inapplicable

                            December 21, 2012

                            Lead Product(s) : Ademetionine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : PPD

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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