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Also known as: 1392275-56-7, Gs-7340-03, Vemlidy, Unii-fwf6q91tzo, Fwf6q91tzo, Tenofovir alafenamide fumarate [usan]
Molecular Formula
Molecular Weight
1069.02  g/mol
InChI Key

1 2D Structure


2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
2.1.2 InChI
2.1.3 InChI Key
2.1.4 Canonical SMILES
2.1.5 Isomeric SMILES
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Gs-7340

2. Tenofovir Alafenamide

3. Vemlidy

2.2.2 Depositor-Supplied Synonyms

1. 1392275-56-7

2. Gs-7340-03

3. Vemlidy

4. Unii-fwf6q91tzo

5. Fwf6q91tzo

6. Tenofovir Alafenamide Fumarate [usan]

7. Chembl2364637

8. Chebi:90923

9. Ex-a2641

10. Ac-30255

11. Tenofovir Alafenamide Fumarate (usan/jan)

12. Gs-734003

13. D10605

14. (s)-isopropyl 2-(((s)-((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate Hemifumarate

15. 1-methylethyl N-((s)-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-l-alaninate, (2e)-2-butenedioate

16. Bis{9-[(2r,5s,7e)-2,7,10-trimethyl-5,8-dioxo-5-phenoxy-3,9-dioxa-6-aza-5lambda5-phosphaundecan-1-yl]-9h-purin-6-aminium} (2e)-but-2-enedioate

17. Bis{propan-2-yl N-[(s)-({[(2r)-1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-l-alaninate} (2e)-but-2-enedioate

18. L-alanine, N-((s)-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl Ester, (2e)-2-butenedioate (2:1)

2.3 Create Date
3 Chemical and Physical Properties
Molecular Weight 1069.02 g/mol
Molecular Formula C46H62N12O14P2
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count24
Rotatable Bond Count26
Exact Mass1068.398 g/mol
Monoisotopic Mass1068.398 g/mol
Topological Polar Surface Area362 A^2
Heavy Atom Count74
Formal Charge0
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Vemlidy is indicated for the treatment of chronic hepatitis B in adults and adolescents (aged 12 years and older with body weight at least 35 kg)

Vemlidy is indicated for the treatment of chronic hepatitis B in adults and adolescents (aged 12 years and older with body weight at least 35 kg).

5 Pharmacology and Biochemistry
5.1 ATC Code

Anatomical main group: J - General antiinfectives for systemic use

Therapeutic subgroup: J05 - Antivirals for systemic use

Pharmacological subgroup: J05A - Agents affecting the virus directly

Chemical subgroup: J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors

Chemical substance: J05AF13 - tenofovir alafenamide


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