1. Trichlorobenzene
1. 87-61-6
2. Trichlorobenzene
3. Vic-trichlorobenzene
4. 1,2,6-trichlorobenzene
5. Benzene, 1,2,3-trichloro-
6. 12002-48-1
7. Nur9777ik4
8. Chebi:35289
9. Nsc-43432
10. Dsstox_cid_6193
11. Dsstox_rid_78052
12. Dsstox_gsid_26193
13. Cas-87-61-6
14. Ccris 5944
15. Hsdb 1502
16. Einecs 201-757-1
17. Nsc 43432
18. Brn 0956882
19. Trichlorobenzene, 1,2,3-
20. Unii-nur9777ik4
21. Ai3-15516
22. 1,2,3-tcb
23. 10-oxapalitic Acid
24. 1,3-trichlorobenzene
25. 1,6-trichlorobenzene
26. 1,2,3-trichlorbenzol
27. Benzene,2,3-trichloro-
28. 1,2-dichlorochlorobenzene
29. 1,2,3-trichloro-benzene
30. Benzene, 1,2,3-trichloro-, Radical Ion(1-)
31. Ec 201-757-1
32. Benzene, 1,2,3-trichloro
33. Schembl23239
34. Mls002415671
35. Bidd:er0649
36. Chembl46557
37. Dtxsid8026193
38. 1,2,3-trichlorobenzene, 99%
39. Hms3039d12
40. Zinc404471
41. Nsc43432
42. Tox21_202113
43. Tox21_300501
44. Ck1107
45. Mfcd00000537
46. Akos007930300
47. 1,2,3-trichlorobenzene [mi]
48. 1,2,3-trichlorobenzene [hsdb]
49. Ncgc00091850-01
50. Ncgc00091850-02
51. Ncgc00091850-03
52. Ncgc00091850-04
53. Ncgc00254273-01
54. Ncgc00259662-01
55. 51703-47-0
56. Smr001370869
57. Db-057010
58. 1,2,3-trichlorobenzene, Analytical Standard
59. Ft-0606225
60. Ft-0606226
61. T0377
62. En300-83456
63. 1,2,3-trichlorobenzene 100 Microg/ml In Isooctane
64. 1,2,3-trichlorobenzene 100 Microg/ml In Methanol
65. Q1917053
66. 1,2,3-trichlorobenzene 10 Microg/ml In Cyclohexane
67. 1,2,3-trichlorobenzene 1000 Microg/ml In Methanol
68. 1,2,3-trichlorobenzene 5000 Microg/ml In Methanol
69. 1,2,3-trichlorobenzene 100 Microg/ml In Acetonitrile
70. 1,2,3-trichlorobenzene, Pestanal(r), Analytical Standard
| Molecular Weight | 181.4 g/mol |
|---|---|
| Molecular Formula | C6H3Cl3 |
| XLogP3 | 4.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 179.930033 g/mol |
| Monoisotopic Mass | 179.930033 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 84.3 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
... Five days after the oral administration of 1,2,3-trichlorobenzene to rabbits, 78% ... of the administered dose was excreted as monophenols.
USEPA; Ambient Water Quality Criteria Doc: Chlorinated Benzenes p.C-38 (1980) EPA 440/5-80-028
All three isomers of trichlorobenzene were absorbed from the gastrointestinal tract, intact skin, and lung.
USEPA; Ambient Water Quality Criteria Doc: Chlorinated Benzenes p.C-35 (1980) EPA 440/5-80-028
The tissue distribution and elimination of 1,2,3-trichlorobenzene, 1,2,4-trichlorobenzene, and 1,3,5-trichlorobenzene were examined in male Sprague Dawley rats. Fasted animals were given single doses of 10 mg/kg of the (14)C labeled isomers by gavage. Serial sacrifices were performed at 0.5, 1, and 24 hr and 1, 2, 7, 14, 28, and 56 days post administration. Radioassays utilized the liver, kidneys, spleen, brain, pancreas, lung, heart, thigh muscle, skin, perirenal fat, testes, bladder, adrenals, epididymis, seminal vesicles, prostate, gastrointestinal tract, blood, and salivary glands. The data for each tissue was fitted to a linear compartmental pharmacokinetic model. The amount of (14)C excreted in urine and feces was determined daily for 1,2,3-trichlorobenzene and 1,3,5-trichlorobenzene isomers. Radioactivity from the labeled isomers appeared in the blood and tissues within 30 min of administration, peaked at approximately 4 hr, and slowly declined to background levels. Radioactivity attributed to 1,2,4-trichlorobenzene dropped to background levels after 28 days. The bladder, kidney, fat, skin, liver, and adrenals showed high 1,2,4-trichlorobenzene activity up to 24 hr post treatment. Radioactivity due to 1,2,3-trichlorobenzene dropped to background levels after 56 days for liver, fat, and skin and 28 days for the other tissues. The highest 1,2,3-trichlorobenzene concentrations were found in liver, fat, kidney, and bladder. Significant levels of radioactivity from 1,3,5-trichlorobenzene remained in the tissues after 56 days for all tissues examined. Approx 85% of 1,3,5-trichlorobenzene and 92% of the 1,2,3-trichlorobenzene were excreted within 24 hr of dosing. Compartmental analysis showed 1,3,5-trichlorobenzene to have the highest values for the linear coefficients of exponential decay.
Chu I et al; J Environ Sci Health Part B: Pesticides, Foods, Contaminants, Agricultural Wastes 22 (4): 439-53 (1987)
1,2,3-trichlorobenzene is metabolized to n-acetyl-s-(2,3,4-trichlorophenyl)-l-cysteine, 2,3,4-trichlorophenol, & 3,4,5-trichlorophenol in rabbits. /from table/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. T-19
In metabolic studies with rabbits using each of the 3 isomeric trichlorobenzenes at 0.5 g/kg, 1,2,3-trichlorobenzene was the one most rapidly metabolized ... in 5 days, 62% ... underwent glucuronic conjugation. The major metabolite was 2,3,4-trichlorophenol; small amt of 3,4,5-trichlorophenol, 3,4,5-trichlorocatechol, & mercapturic acid were ... detected.
National Research Council. Drinking Water & Health Volume 1. Washington, DC: National Academy Press, 1977., p. 773
... Five days after the oral administration of 1,2,3-trichlorobenzene to rabbits, 78% ... of the administered dose was excreted as monophenols.
USEPA; Ambient Water Quality Criteria Doc: Chlorinated Benzenes p.C-38 (1980) EPA 440/5-80-028
Approximate half-life of 1,2,3-trichlorobenzene is 2 days.
USEPA; Ambient Water Quality Criteria Doc: Chlorinated Benzenes p.C-38 (1980) EPA 440/5-80-028
