Please Wait
Applying Filters...
menu
    • menu
    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients, & custom-made solutions to our customers.

    Virtual Booth

    Contact Supplier

    Inke S.A: APIs manufacturing plant.

    Virtual Booth

    Contact Supplier

    xyz-pharma-2025-04-21

    Virtual Booth

    Contact Supplier

    AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Send me more info on How To Grow My Business Digitally?
    Menu

    G207

    DEVELOPMENTS

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Wf8nwa83re, G 207, G 207 [who-dd], G207, G-207, 80156-87-2
    Molecular Formula
    C25H28N4O
    Molecular Weight
    400.5  g/mol
    InChI Key
    ZUGKFNYCFBDWIO-UHFFFAOYSA-N
    FDA UNII
    WF8NWA83RE
    G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to make them utilizable as a therapeutic agent in humans.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4-butylphenyl)-[4-[(4-propoxyphenyl)diazenyl]phenyl]diazene
    2.1.2 InChI
    InChI=1S/C25H28N4O/c1-3-5-6-20-7-9-21(10-8-20)26-27-22-11-13-23(14-12-22)28-29-24-15-17-25(18-16-24)30-19-4-2/h7-18H,3-6,19H2,1-2H3
    2.1.3 InChI Key
    ZUGKFNYCFBDWIO-UHFFFAOYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    WF8NWA83RE
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Wf8nwa83re

    2. G 207

    3. G 207 [who-dd]

    4. G207

    5. G-207

    6. 80156-87-2

    7. 2136340-90-2

    8. 162320-00-5

    9. Unii-wf8nwa83re

    10. Schembl12425118

    11. Schembl24849964

    12. Dtxsid70612659

    13. Zugkfnycfbdwio-uhfffaoysa-n

    14. (e)-1-(4-butylphenyl)-2-{4-[(e)-(4-propoxyphenyl)diazenyl]phenyl}diazene

    2.4 Create Date
    2007-12-05
    3 Chemical and Physical Properties
    Molecular Weight 400.5 g/mol
    Molecular Formula C25H28N4O
    XLogP38.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area58.7
    Heavy Atom Count30
    Formal Charge0
    Complexity499
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in brain cancer.

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    G207, Cancer killing viruses are modified to make them utilizable as a therapeutic agent in human by switching off certain genes that normally enable the virus to multiply in healthy cells, which would destroy these cells. As a result of this genetic modification, the HSVs are able to reproduce in tumor cells solely, since only this offer an environment that compensates for the loss of the removed viral genes. Consequently, the virus is able to replicate in the tumor cells, selectively destroying them without harming healthy tissue.