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Chemistry

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Also known as: Vinorelbine tartrate, 125317-39-7, Kw 2307, Navelbine (tn), Vinorelbine ditartrate (jan), Vinorelbine bitartarate
Molecular Formula
C53H66N4O20
Molecular Weight
1079.1  g/mol
InChI Key
CILBMBUYJCWATM-NPJYPKOYSA-N

Vinorelbine Tartrate
A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.
1 2D Structure

Vinorelbine Tartrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3R)-2,3-dihydroxybutanedioic acid;methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(12S)-16-ethyl-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
2.1.2 InChI
InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+,44-,45-;2*1-,2-/m011/s1
2.1.3 InChI Key
CILBMBUYJCWATM-NPJYPKOYSA-N
2.1.4 Canonical SMILES
CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
2.1.5 Isomeric SMILES
CCC1=CC2C[C@@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 5' Nor Anhydrovinblastine

2. 5'-nor-anhydrovinblastine

3. Kw 2307

4. Kw-2307

5. Kw2307

6. Navelbine

7. Vinorelbine

8. Vinorelbine Tartrate

2.2.2 Depositor-Supplied Synonyms

1. Vinorelbine Tartrate

2. 125317-39-7

3. Kw 2307

4. Navelbine (tn)

5. Vinorelbine Ditartrate (jan)

6. Vinorelbine Bitartarate

7. Vinorelbine Tartrate (usp)

8. Schembl4334811

9. Schembl16766511

10. Amy22244

11. S4269

12. Akos037748842

13. Ccg-270632

14. As-75352

15. D01935

16. Bis((2r,3r)-2,3-dihydroxybutanedioic Acid); Methyl (1r,9r,10s,11r,12r,19r)-11-(acetyloxy)-12-ethyl-4-[(12s)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0(3),(1)(1).0?,?]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0(1),?.0(2),?.0(1)?,(1)?]nonadeca-2(7),3,5,13-tetraene-10-carboxylate

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 1079.1 g/mol
Molecular Formula C53H66N4O20
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count23
Rotatable Bond Count16
Exact Mass1078.42704051 g/mol
Monoisotopic Mass1078.42704051 g/mol
Topological Polar Surface Area364 Ų
Heavy Atom Count77
Formal Charge0
Complexity1820
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameVinorelbine tartrate
Drug LabelVinorelbine Tartrate Injection is for intravenous administration. Each vial contains vinorelbine tartrate equivalent to 10mg (1-mL vial) or 50 mg (5-mL vial) vinorelbine in Water for Injection, USP. No preservatives or other additives are present....
Active IngredientVinorelbine tartrate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyBedford; Hospira; Jiangsu Hansoh Pharm; Teva Pharms Usa; Actavis Elizabeth; Fresenius Kabi Usa; Hikma Maple; Ebewe Pharma; Dr Reddys Labs

2 of 2  
Drug NameVinorelbine tartrate
Drug LabelVinorelbine Tartrate Injection is for intravenous administration. Each vial contains vinorelbine tartrate equivalent to 10mg (1-mL vial) or 50 mg (5-mL vial) vinorelbine in Water for Injection, USP. No preservatives or other additives are present....
Active IngredientVinorelbine tartrate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyBedford; Hospira; Jiangsu Hansoh Pharm; Teva Pharms Usa; Actavis Elizabeth; Fresenius Kabi Usa; Hikma Maple; Ebewe Pharma; Dr Reddys Labs

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)


Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)


API SUPPLIERS

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01

Minakem

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothMinakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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02

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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  • WHO-GMP

Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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03

Minakem (formerly Delmar Chemicals...

Canada

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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26th North American ISSX
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  • fda
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Virtual BoothMinakem is manufacturing small molecules APIs including corticosteroids

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Transo-Pharm USA LLC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Shanghai Minbiotech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothShanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

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Shanghai Minbiotech CB

07

Zeon Pharma Industries India Pvt L...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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Virtual BoothZeon is a manufacturer and supplier of APIs & Intermediates.

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08

Hubei Honch Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

26th North American ISSX
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Hubei Honch Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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09

Pierre Fabre

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

26th North American ISSX
Not Confirmed
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Pierre Fabre

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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10

Pierre Fabre

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

26th North American ISSX
Not Confirmed
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Pierre Fabre

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF

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Virtual BoothMinakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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GDUFA

DMF Review : Complete

Rev. Date : 2016-04-23

Pay. Date : 2016-03-23

DMF Number : 14619

Submission : 1999-12-13

Status : Active

Type : II

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02

26th North American ISSX
Not Confirmed

03

Cipla Ltd

India

USDMF

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26th North American ISSX
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03

Cipla Ltd

India
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26th North American ISSX
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 20158

Submission : 2009-02-19

Status : Inactive

Type : II

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Eriochem Sa

Argentina

USDMF

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26th North American ISSX
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04

Eriochem Sa

Argentina
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26th North American ISSX
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 16706

Submission : 2003-07-14

Status : Inactive

Type : II

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Exopharm Co Ltd

Australia

USDMF

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26th North American ISSX
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Exopharm Co Ltd

Australia
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 19094

Submission : 2006-01-03

Status : Inactive

Type : II

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26th North American ISSX
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06

26th North American ISSX
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 16011

Submission : 2002-06-14

Status : Inactive

Type : II

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26th North American ISSX
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26th North American ISSX
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09

Synbias Pharma Ltd

Ukraine

USDMF

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09

26th North American ISSX
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 21929

Submission : 2008-09-01

Status : Inactive

Type : II

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26th North American ISSX
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10

26th North American ISSX
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 15956

Submission : 2002-04-25

Status : Inactive

Type : II

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API Reference Price

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NEHRU BRIDGE, ASHRAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1629484200,"product":"VINORELBINE TARTRATE PH.EUR","address":"PLOT NO.2, MAITHRIVIHAR, AMEERPET,","city":"HYDERABAD, AP.","supplier":"HANSOH PHARMA","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"EUGIA PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.005","unit":"KGS","unitRateFc":"90000","totalValueFC":"456.3","currency":"USD","unitRateINR":"6768000","date":"21-Aug-2021","totalValueINR":"33840","totalValueInUsd":"456.3","indian_port":"HYDERABAD AIR","hs_no":"29420090","bill_no":"5143898","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"","customerAddress":"PLOT NO.2, MAITHRIVIHAR, AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1632940200,"product":"VINORELBINE TARTRATE PH EUR","address":"2ND FLOOR, CHINUBHAI CENTRE,OFF. 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13-Jan-2021
21-Jun-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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(USD/KGS)
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