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1. Schembl13342952
2. Dtxsid90235521
Molecular Weight | 925.2 g/mol |
---|---|
Molecular Formula | C49H76N6O11 |
XLogP3 | 4.6 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 11 |
Rotatable Bond Count | 27 |
Exact Mass | 924.55720726 g/mol |
Monoisotopic Mass | 924.55720726 g/mol |
Topological Polar Surface Area | 212 Ų |
Heavy Atom Count | 66 |
Formal Charge | 0 |
Complexity | 1680 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 8 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
No approved indication.
Selectively targets cancer cells expressing mutant epidermal growth factor receptor (EGFR) vIII or over expressing wild type EGFR. Depatuxizumab mafodotin acts on these cells to inhibit microtuble polymerization thus disrupting mitosis and vesicular trafficking
Depatuxizumab is a chimeric monoclonal antibody for EGFR which is linked to monomethyl aurastatin F via a maleimidocaproyl linker (mafodotin). Once delivered to the cancer cell, the mafodotin component is able to bind to tubulin and inhibit the exchange of GDP for GTP necessary for the polymerization of tubulin subunits to form microtubules. The inhibition of microtubule polymerization disrupts mitosis and interferes with vesicle trafficking in the cancer cell.
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PharmaCompass offers a list of Mafodotin [Usan] API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mafodotin [Usan] manufacturer or Mafodotin [Usan] supplier for your needs.
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PharmaCompass also assists you with knowing the Mafodotin [Usan] API Price utilized in the formulation of products. Mafodotin [Usan] API Price is not always fixed or binding as the Mafodotin [Usan] Price is obtained through a variety of data sources. The Mafodotin [Usan] Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A mc-MMAF, mcMMAF, SGD-1269 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of mc-MMAF, mcMMAF, SGD-1269, including repackagers and relabelers. The FDA regulates mc-MMAF, mcMMAF, SGD-1269 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. mc-MMAF, mcMMAF, SGD-1269 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A mc-MMAF, mcMMAF, SGD-1269 supplier is an individual or a company that provides mc-MMAF, mcMMAF, SGD-1269 active pharmaceutical ingredient (API) or mc-MMAF, mcMMAF, SGD-1269 finished formulations upon request. The mc-MMAF, mcMMAF, SGD-1269 suppliers may include mc-MMAF, mcMMAF, SGD-1269 API manufacturers, exporters, distributors and traders.
click here to find a list of mc-MMAF, mcMMAF, SGD-1269 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A mc-MMAF, mcMMAF, SGD-1269 DMF (Drug Master File) is a document detailing the whole manufacturing process of mc-MMAF, mcMMAF, SGD-1269 active pharmaceutical ingredient (API) in detail. Different forms of mc-MMAF, mcMMAF, SGD-1269 DMFs exist exist since differing nations have different regulations, such as mc-MMAF, mcMMAF, SGD-1269 USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A mc-MMAF, mcMMAF, SGD-1269 DMF submitted to regulatory agencies in the US is known as a USDMF. mc-MMAF, mcMMAF, SGD-1269 USDMF includes data on mc-MMAF, mcMMAF, SGD-1269's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The mc-MMAF, mcMMAF, SGD-1269 USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of mc-MMAF, mcMMAF, SGD-1269 suppliers with USDMF on PharmaCompass.
mc-MMAF, mcMMAF, SGD-1269 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of mc-MMAF, mcMMAF, SGD-1269 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right mc-MMAF, mcMMAF, SGD-1269 GMP manufacturer or mc-MMAF, mcMMAF, SGD-1269 GMP API supplier for your needs.
A mc-MMAF, mcMMAF, SGD-1269 CoA (Certificate of Analysis) is a formal document that attests to mc-MMAF, mcMMAF, SGD-1269's compliance with mc-MMAF, mcMMAF, SGD-1269 specifications and serves as a tool for batch-level quality control.
mc-MMAF, mcMMAF, SGD-1269 CoA mostly includes findings from lab analyses of a specific batch. For each mc-MMAF, mcMMAF, SGD-1269 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
mc-MMAF, mcMMAF, SGD-1269 may be tested according to a variety of international standards, such as European Pharmacopoeia (mc-MMAF, mcMMAF, SGD-1269 EP), mc-MMAF, mcMMAF, SGD-1269 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (mc-MMAF, mcMMAF, SGD-1269 USP).