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    Chemistry

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    Also known as: 181183-52-8, Almotriptan maleate, Axert, Las 31416 d,l-malate acid, Almotriptan (malate), Almogran
    Molecular Formula
    C21H31N3O7S
    Molecular Weight
    469.6  g/mol
    InChI Key
    QHATUKWEVNMHRY-UHFFFAOYSA-N
    FDA UNII
    PJP312605E
    Almotriptan Malate
    Almotriptan Malate is the malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.
    1 2D Structure

    Almotriptan Malate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine;2-hydroxybutanedioic acid
    2.1.2 InChI
    InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
    2.1.3 InChI Key
    QHATUKWEVNMHRY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3.C(C(C(=O)O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    PJP312605E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Almogran

    2. Almotriptan

    3. Axert

    2.3.2 Depositor-Supplied Synonyms

    1. 181183-52-8

    2. Almotriptan Maleate

    3. Axert

    4. Las 31416 D,l-malate Acid

    5. Almotriptan (malate)

    6. Almogran

    7. Pnu-180638e

    8. Almotriptan Malate [usan]

    9. Almotriptan D,l-hydrogenmalate

    10. Chebi:53781

    11. Las-31416 D,l-malate Acid

    12. Pjp312605e

    13. 181183-52-8(almotriptan Malate)

    14. Las-31416-d,l-malate-acid

    15. N,n-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1h-indol-3-yl)ethan-1-amine 2-hydroxysuccinate

    16. 1-(((3-(2-(dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine Malate (1:1)

    17. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine, Hydroxybutanedioate (1:1)

    18. N,n-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1h-indol-3-yl]ethanamine;2-hydroxybutanedioic Acid

    19. Pnu 180638e

    20. Unii-pjp312605e

    21. Sr-05000001986

    22. Axert (tn)

    23. Almotriptan Malate (usp)

    24. 1-[[[2-(dimethyl-amino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine Malate

    25. Almotriptan Malate (axert)

    26. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine, Hydroxybutanedionate (1:1)

    27. Mls006010048

    28. Schembl221131

    29. Almotriptan Maleate [mi]

    30. Chembl1200521

    31. Dtxsid1044225

    32. Almotriptan Malate [vandf]

    33. Almotriptan Malate(pnu180638)

    34. Hms3651a12

    35. Hms3884p05

    36. Almotriptan Malate [mart.]

    37. Almotriptan Malate [usp-rs]

    38. Almotriptan Malate [who-dd]

    39. Bcp05632

    40. Hy-b0383

    41. Mfcd08067740

    42. Pnu180638

    43. S2096

    44. (zznon-labelled)almotriptan-d6 Malate

    45. Akos015950790

    46. Bcp9000276

    47. Ccg-269445

    48. Pnu 180638

    49. Almotriptan Malate [orange Book]

    50. Almotriptan Malate [ep Monograph]

    51. Almotriptan Malate [usp Monograph]

    52. As-12142

    53. Butanedioic Acid, Hydroxy-, Compd. With 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine (1:1)

    54. Smr004701216

    55. Ft-0661519

    56. Sw219418-1

    57. D02825

    58. F14758

    59. J-011571

    60. Sr-05000001986-2

    61. Q27124206

    62. 1-(((3-(2-(dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine Malate

    63. 3-[2-(dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1h-indole Malate

    64. 1-(((3-(2-(dimethylamino)ethyl)-1h-indol-5-yl)methyl)sulfonyl)pyrrolidine Hydroxybutanedioate

    65. Butanedioic Acid, 2-hydroxy-, Compd. With N,n-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1h-indole-3-ethanamine (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 469.6 g/mol
    Molecular Formula C21H31N3O7S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count9
    Exact Mass469.18827151 g/mol
    Monoisotopic Mass469.18827151 g/mol
    Topological Polar Surface Area160 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity612
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameAlmotriptan malate
    Drug LabelAXERT (almotriptan malate) Tablets contain almotriptan malate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Almotriptan malate is chemically designated as 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidi...
    Active IngredientAlmotriptan malate
    Dosage FormTablet
    Routeoral
    Strength6.25mg; 12.5mg
    Market StatusTentative Approval
    CompanyTeva Pharms

    2 of 2  
    Drug NameAlmotriptan malate
    Drug LabelAXERT (almotriptan malate) Tablets contain almotriptan malate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Almotriptan malate is chemically designated as 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidi...
    Active IngredientAlmotriptan malate
    Dosage FormTablet
    Routeoral
    Strength6.25mg; 12.5mg
    Market StatusTentative Approval
    CompanyTeva Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Serotonin 1d Receptor Agonists [MoA]; Serotonin-1b and Serotonin-1d Receptor Agonist [EPC]; Serotonin 1b Receptor Agonists [MoA]

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    06-Jan-2022
    28-May-2025
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    DOSAGE - TABLET;ORAL - EQ 12.5MG BASE **Feder...DOSAGE - TABLET;ORAL - EQ 12.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21001

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    DOSAGE - TABLET;ORAL - EQ 6.25MG BASE **Feder...DOSAGE - TABLET;ORAL - EQ 6.25MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 21001

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    ABOUT THIS PAGE

    Looking for 181183-52-8 / Almotriptan Malate API manufacturers, exporters & distributors?

    Almotriptan Malate manufacturers, exporters & distributors 1

    77

    PharmaCompass offers a list of Almotriptan Malate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Almotriptan Malate manufacturer or Almotriptan Malate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Almotriptan Malate manufacturer or Almotriptan Malate supplier.

    PharmaCompass also assists you with knowing the Almotriptan Malate API Price utilized in the formulation of products. Almotriptan Malate API Price is not always fixed or binding as the Almotriptan Malate Price is obtained through a variety of data sources. The Almotriptan Malate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Almotriptan Malate

    Synonyms

    181183-52-8, Almotriptan maleate, Axert, Las 31416 d,l-malate acid, Almotriptan (malate), Almogran

    Cas Number

    181183-52-8

    Unique Ingredient Identifier (UNII)

    PJP312605E

    About Almotriptan Malate

    Almotriptan Malate is the malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

    LAS 31416 Manufacturers

    A LAS 31416 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LAS 31416, including repackagers and relabelers. The FDA regulates LAS 31416 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LAS 31416 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of LAS 31416 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    LAS 31416 Suppliers

    A LAS 31416 supplier is an individual or a company that provides LAS 31416 active pharmaceutical ingredient (API) or LAS 31416 finished formulations upon request. The LAS 31416 suppliers may include LAS 31416 API manufacturers, exporters, distributors and traders.

    click here to find a list of LAS 31416 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    LAS 31416 USDMF

    A LAS 31416 DMF (Drug Master File) is a document detailing the whole manufacturing process of LAS 31416 active pharmaceutical ingredient (API) in detail. Different forms of LAS 31416 DMFs exist exist since differing nations have different regulations, such as LAS 31416 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A LAS 31416 DMF submitted to regulatory agencies in the US is known as a USDMF. LAS 31416 USDMF includes data on LAS 31416's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The LAS 31416 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of LAS 31416 suppliers with USDMF on PharmaCompass.

    LAS 31416 CEP

    A LAS 31416 CEP of the European Pharmacopoeia monograph is often referred to as a LAS 31416 Certificate of Suitability (COS). The purpose of a LAS 31416 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of LAS 31416 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of LAS 31416 to their clients by showing that a LAS 31416 CEP has been issued for it. The manufacturer submits a LAS 31416 CEP (COS) as part of the market authorization procedure, and it takes on the role of a LAS 31416 CEP holder for the record. Additionally, the data presented in the LAS 31416 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the LAS 31416 DMF.

    A LAS 31416 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. LAS 31416 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of LAS 31416 suppliers with CEP (COS) on PharmaCompass.

    LAS 31416 WC

    A LAS 31416 written confirmation (LAS 31416 WC) is an official document issued by a regulatory agency to a LAS 31416 manufacturer, verifying that the manufacturing facility of a LAS 31416 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting LAS 31416 APIs or LAS 31416 finished pharmaceutical products to another nation, regulatory agencies frequently require a LAS 31416 WC (written confirmation) as part of the regulatory process.

    click here to find a list of LAS 31416 suppliers with Written Confirmation (WC) on PharmaCompass.

    LAS 31416 NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing LAS 31416 as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for LAS 31416 API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture LAS 31416 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain LAS 31416 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a LAS 31416 NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of LAS 31416 suppliers with NDC on PharmaCompass.

    LAS 31416 GMP

    LAS 31416 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of LAS 31416 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right LAS 31416 GMP manufacturer or LAS 31416 GMP API supplier for your needs.

    LAS 31416 CoA

    A LAS 31416 CoA (Certificate of Analysis) is a formal document that attests to LAS 31416's compliance with LAS 31416 specifications and serves as a tool for batch-level quality control.

    LAS 31416 CoA mostly includes findings from lab analyses of a specific batch. For each LAS 31416 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    LAS 31416 may be tested according to a variety of international standards, such as European Pharmacopoeia (LAS 31416 EP), LAS 31416 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LAS 31416 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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