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1. 17-ethynyl-5-androstene-3, 7, 17-triol
2. 17-ethynyl-5-androstene-3,7,17-triol
3. He-3286
4. He3286
1. He3286
2. 1001100-69-1
3. He 3286
4. Bezisterim
5. He-3286
6. Unii-ph8858757i
7. Pregn-5-en-20-yne-3,7,17-triol, (3beta,7beta,17alpha)-
8. Ph8858757i
9. 3beta,7beta,17beta-trihydroxy-17alpha-ethynylandrost-5-ene
10. (3s,7r,8r,9s,10r,13s,14s,17r)-17-ethynyl-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,7,17-triol
11. Bezisterim [inn]
12. 17-ethynyl-5-androstene-3, 7, 17-triol
13. Schembl512549
14. Chembl4297284
15. Dtxsid501267252
16. Akos040749677
17. Db05212
18. Hy-108039
19. Cs-0027210
20. Ns00072554
21. G13918
22. 17alpha-pregn-5-en-20-yne-3beta,7beta,17-triol
23. Q27286562
24. 17.alpha.-ethynyl-5-androstene-3.beta.,7.beta.,17.beta.-triol
25. Pregn-5-en-20-yne-3,7,17-triol, (3.beta.,7.beta.,17.alpha.)-
| Molecular Weight | 330.5 g/mol |
|---|---|
| Molecular Formula | C21H30O3 |
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | g/mol |
| Monoisotopic Mass | g/mol |
| Topological Polar Surface Area | 60.7 |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 630 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of rheumatoid arthritis and type 2 diabetes.
Absorption
Up to 25% oral bioavailability in mice.
Potential mechanisms of action for HE3286 include regulation of NF-kB and increasing the production of regulatory T cells (Treg cells). NF-kB is a well-known transcription factor that controls the production of inflammatory cytokines such as TNF-a and interferon-g. Treg cells are referred to in the scientific literature as the peacekeepers of the body. Their role is to keep the immune system from attacking the body itself. Recent studies of Treg cells indicate that they may play a broader role than simply preventing autoimmune conditions. Manipulation of these cells may offer new treatments for conditions ranging from diabetes and organ rejection to cancer and infectious diseases. In type II diabetes, moderate inhibition of NF-kB improves glucose tolerance. [Press Release - Hollis-Eden Pharmaceuticals]
Drugs in Development
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PharmaCompass offers a list of Bezisterim API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Bezisterim manufacturer or Bezisterim supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Bezisterim manufacturer or Bezisterim supplier.
PharmaCompass also assists you with knowing the Bezisterim API Price utilized in the formulation of products. Bezisterim API Price is not always fixed or binding as the Bezisterim Price is obtained through a variety of data sources. The Bezisterim Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A HE 3286 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of HE 3286, including repackagers and relabelers. The FDA regulates HE 3286 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. HE 3286 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A HE 3286 supplier is an individual or a company that provides HE 3286 active pharmaceutical ingredient (API) or HE 3286 finished formulations upon request. The HE 3286 suppliers may include HE 3286 API manufacturers, exporters, distributors and traders.
HE 3286 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of HE 3286 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right HE 3286 GMP manufacturer or HE 3286 GMP API supplier for your needs.
A HE 3286 CoA (Certificate of Analysis) is a formal document that attests to HE 3286's compliance with HE 3286 specifications and serves as a tool for batch-level quality control.
HE 3286 CoA mostly includes findings from lab analyses of a specific batch. For each HE 3286 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
HE 3286 may be tested according to a variety of international standards, such as European Pharmacopoeia (HE 3286 EP), HE 3286 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (HE 3286 USP).
