Find IDRX-42 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: M4205, 2590556-80-0, Idrx-42, M-4205, N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine, Idrx42
Molecular Formula
C29H32N8O
Molecular Weight
508.6  g/mol
InChI Key
LVMAULGVWBINFP-UHFFFAOYSA-N
FDA UNII
Y6UHU32G5Z

IDRX-42
KIT-mutant Inhibitor IDRX-42 is an orally bioavailable small molecule inhibitor of multiple mutated forms of mast/stem cell factor receptor KIT (c-Kit; SCFR), with potential antineoplastic activity. Upon oral administration, KIT-mutant inhibitor IDRX-42 targets, binds to and inhibits specific c-Kit mutants. This may inhibit tumor cell proliferation in cancer cell types that overexpress these c-Kit mutations. c-Kit, a transmembrane protein and receptor tyrosine kinase (RTK) overexpressed in various solid tumors and hematological malignancies, plays a key role in the regulation of cell differentiation and proliferation. Mutant forms of c-Kit are often associated with tumor chemoresistance.
1 2D Structure

IDRX-42

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine
2.1.2 InChI
InChI=1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)
2.1.3 InChI Key
LVMAULGVWBINFP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6
2.2 Other Identifiers
2.2.1 UNII
Y6UHU32G5Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Idrx-42

2. Idrx42

3. M4205

4. N-((4-(1-methylpyrazol-4-yl)phenyl)methyl)-6-(7-(3-pyrrolidin-1-ylpropoxy)imidazo(1,2-a)pyridin-3-yl)pyrimidin-4-amine

2.3.2 Depositor-Supplied Synonyms

1. M4205

2. 2590556-80-0

3. Idrx-42

4. M-4205

5. N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine

6. Idrx42

7. Y6uhu32g5z

8. Chembl5314917

9. Schembl22918830

10. Gtpl11510

11. Ex-a5351

12. Nsc832522

13. Akos040759930

14. Nsc-832522

15. Compound 32 [pmid: 36728508]

16. Ms-29449

17. Cid 155587867

18. Hy-132166

19. Cs-0163532

20. G17845

21. M4205?

22. [4-(methyl-1h-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] Pyridin-3-yl]-pyrimidin-4-yl]-amine

23. K3r

2.4 Create Date
2021-02-21
3 Chemical and Physical Properties
Molecular Weight 508.6 g/mol
Molecular Formula C29H32N8O
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area85.4
Heavy Atom Count38
Formal Charge0
Complexity715
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2590556-80-0 / IDRX-42 API manufacturers, exporters & distributors?

IDRX-42 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of IDRX-42 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right IDRX-42 manufacturer or IDRX-42 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred IDRX-42 manufacturer or IDRX-42 supplier.

PharmaCompass also assists you with knowing the IDRX-42 API Price utilized in the formulation of products. IDRX-42 API Price is not always fixed or binding as the IDRX-42 Price is obtained through a variety of data sources. The IDRX-42 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

IDRX-42

Synonyms

M4205, 2590556-80-0, M-4205, N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine, Idrx42, Y6uhu32g5z

Cas Number

2590556-80-0

Unique Ingredient Identifier (UNII)

Y6UHU32G5Z

About IDRX-42

KIT-mutant Inhibitor IDRX-42 is an orally bioavailable small molecule inhibitor of multiple mutated forms of mast/stem cell factor receptor KIT (c-Kit; SCFR), with potential antineoplastic activity. Upon oral administration, KIT-mutant inhibitor IDRX-42 targets, binds to and inhibits specific c-Kit mutants. This may inhibit tumor cell proliferation in cancer cell types that overexpress these c-Kit mutations. c-Kit, a transmembrane protein and receptor tyrosine kinase (RTK) overexpressed in various solid tumors and hematological malignancies, plays a key role in the regulation of cell differentiation and proliferation. Mutant forms of c-Kit are often associated with tumor chemoresistance.

G17845 Manufacturers

A G17845 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of G17845, including repackagers and relabelers. The FDA regulates G17845 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. G17845 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

G17845 Suppliers

A G17845 supplier is an individual or a company that provides G17845 active pharmaceutical ingredient (API) or G17845 finished formulations upon request. The G17845 suppliers may include G17845 API manufacturers, exporters, distributors and traders.

G17845 GMP

G17845 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of G17845 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right G17845 GMP manufacturer or G17845 GMP API supplier for your needs.

G17845 CoA

A G17845 CoA (Certificate of Analysis) is a formal document that attests to G17845's compliance with G17845 specifications and serves as a tool for batch-level quality control.

G17845 CoA mostly includes findings from lab analyses of a specific batch. For each G17845 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

G17845 may be tested according to a variety of international standards, such as European Pharmacopoeia (G17845 EP), G17845 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (G17845 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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