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    Chemistry

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    Also known as: Etacrynic acid, 58-54-8, Ethacrynate, Edecrin, Etacrinic acid, Hydromedin
    Molecular Formula
    C13H12Cl2O4
    Molecular Weight
    303.13  g/mol
    InChI Key
    AVOLMBLBETYQHX-UHFFFAOYSA-N
    FDA UNII
    M5DP350VZV
    Ethacrynic Acid
    A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
    Ethacrynic acid is a Loop Diuretic. The physiologic effect of ethacrynic acid is by means of Increased Diuresis at Loop of Henle.
    1 2D Structure

    Ethacrynic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
    2.1.2 InChI
    InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
    2.1.3 InChI Key
    AVOLMBLBETYQHX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    M5DP350VZV
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acid, Etacrynic

    2. Acid, Ethacrinic

    3. Acid, Ethacrynic

    4. Edecrin

    5. Etacrynic Acid

    6. Ethacrinic Acid

    7. Ethacrynate Sodium

    8. Ethacrynic Acid, Sodium Salt

    9. Hydromedin

    10. Sodium, Ethacrynate

    2.3.2 Depositor-Supplied Synonyms

    1. Etacrynic Acid

    2. 58-54-8

    3. Ethacrynate

    4. Edecrin

    5. Etacrinic Acid

    6. Hydromedin

    7. Taladren

    8. Crinuryl

    9. Edecril

    10. Edecrina

    11. Endecril

    12. Hidromedin

    13. Otacril

    14. Mingit

    15. Reomax

    16. Uregit

    17. Etakrinic Acid

    18. Methylenebutyrylphenoxyacetic Acid

    19. Mk-595

    20. Ethacrinique (acide)

    21. Acido Etacrinico

    22. Acide Etacrynique

    23. Acidum Etacrynicum

    24. Kyselina Ethakrynova

    25. Kyselina Ethakrynova [czech]

    26. 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic Acid

    27. Acide Etacrynique [inn-french]

    28. Acido Etacrinico [inn-spanish]

    29. Acidum Etacrynicum [inn-latin]

    30. (2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic Acid

    31. Methylenebutyryl Phenoxyacetic Acid

    32. [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetic Acid

    33. 2,3-dichloro-4-(2-methylenebutyl)phenoxyacetic Acid

    34. Mk 595

    35. Nsc 85791

    36. (2,3-dichloro-4-(2-methylenebutyryl)phenoxy)acetic Acid

    37. Nsc 624008

    38. Brn 1915060

    39. Acetic Acid, (2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)-

    40. Etacrynic Acid [inn]

    41. 2,3-dichloro-4-(2-methylenebutyryl)phenoxy Acetic Acid

    42. (4-(2-methylenebutyryl)-2,3-dichlorophenoxy)acetic Acid

    43. 2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetic Acid

    44. Nsc-85791

    45. Chembl456

    46. Nsc-624008

    47. Acetic Acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-

    48. Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova [czech]

    49. M5dp350vzv

    50. 58-54-8 (free Acid)

    51. Mls000069535

    52. Mls002701928

    53. Chebi:4876

    54. [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic Acid

    55. Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova

    56. Acetic Acid, (2,3-dichloro-4-(2-methylenebutyryl)phenoxy)-

    57. Nsc85791

    58. Nsc624008

    59. Cas-58-54-8

    60. [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic Acid

    61. [4-(2-methylenebutyryl)-2,3-dichlorophenoxy]acetic Acid

    62. Ncgc00016260-05

    63. 2-[2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic Acid

    64. Smr000058600

    65. [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic Acid

    66. Ethacryinic Acid

    67. Dsstox_cid_5257

    68. Dsstox_rid_77718

    69. Dsstox_gsid_25257

    70. Ethacrynic Acid [usan:ban]

    71. Ccris 4638

    72. Hsdb 2136

    73. Ethacrynic Acid (usp)

    74. Sr-01000003010

    75. Einecs 200-384-1

    76. Unii-m5dp350vzv

    77. Etacrynicacid

    78. Etacrynsaure

    79. Crinuril

    80. Acetic Acid, [2,3-dichloro-4-(2-methylenebutyryl)phenoxy]-

    81. Etacrynic-acid

    82. Ethacrynic Acid [usan:usp]

    83. 1gsf

    84. 2gss

    85. Prestwick_671

    86. Opera_id_61

    87. Spectrum_000813

    88. Prestwick0_000259

    89. Prestwick1_000259

    90. Prestwick2_000259

    91. Prestwick3_000259

    92. Spectrum2_000097

    93. Spectrum3_000425

    94. Spectrum4_000544

    95. Spectrum5_000680

    96. E0526

    97. Bmse000134

    98. Schembl26353

    99. Bspbio_000078

    100. Bspbio_002010

    101. Etacrynic Acid [jan]

    102. Ethacrynic Acid [mi]

    103. Kbiogr_001207

    104. Kbioss_001293

    105. Mls002548854

    106. Divk1c_000900

    107. Etacrynic Acid (jp17/inn)

    108. Spectrum1500287

    109. Spbio_000054

    110. Spbio_002297

    111. Ethacrynic Acid [hsdb]

    112. Ethacrynic Acid [usan]

    113. 2,3-dichloro-4-(2-methylenebutyryl)phenoxyacetic Acid

    114. Bpbio1_000086

    115. Gtpl7179

    116. Zinc1382

    117. Etacrynic Acid [mart.]

    118. Ethacrynic Acid [vandf]

    119. Dtxsid3025257

    120. Etacrynic Acid [who-dd]

    121. Hms502m22

    122. Kbio1_000900

    123. Kbio2_001293

    124. Kbio2_003861

    125. Kbio2_006429

    126. Kbio3_001230

    127. Ninds_000900

    128. Hms1568d20

    129. Hms1920m16

    130. Hms2089n17

    131. Hms2091d17

    132. Hms2095d20

    133. Hms3259g03

    134. Hms3712d20

    135. Pharmakon1600-01500287

    136. Hy-b1640

    137. Ethacrynic Acid, >=97% (hplc)

    138. Tox21_110335

    139. Tox21_201102

    140. Bdbm50186231

    141. Ccg-38915

    142. Etacrynic Acid [ep Impurity]

    143. Mfcd00056693

    144. Nsc757026

    145. S5561

    146. Wln: Qv1or Bg Cg Dvy2&u1

    147. Etacrynic Acid [ep Monograph]

    148. Ethacrynic Acid [orange Book]

    149. Gst Inhibitor-2 (ethacrynic Acid))

    150. Akos003404732

    151. Tox21_110335_1

    152. Db00903

    153. Ethacrynic Acid [usp Monograph]

    154. Ks-1453

    155. Nc00450

    156. Nsc-757026

    157. Idi1_000900

    158. Ncgc00016260-01

    159. Ncgc00016260-02

    160. Ncgc00016260-03

    161. Ncgc00016260-04

    162. Ncgc00016260-06

    163. Ncgc00016260-07

    164. Ncgc00016260-08

    165. Ncgc00016260-09

    166. Ncgc00016260-10

    167. Ncgc00016260-11

    168. Ncgc00016260-13

    169. Ncgc00022601-03

    170. Ncgc00022601-04

    171. Ncgc00022601-05

    172. Ncgc00258654-01

    173. Nci60_041898

    174. Sbi-0051374.p003

    175. Db-053221

    176. Ab00051988

    177. Cs-0013591

    178. A51097

    179. D00313

    180. Ab00051988-19

    181. Ab00051988_20

    182. A831918

    183. Q418571

    184. Sr-01000003010-2

    185. Sr-01000003010-3

    186. Brd-k63630713-001-05-0

    187. Brd-k63630713-001-15-9

    188. [2,3-dichloro-4-(2-ethylacryloyl)phenoxy]acetic Acid #

    189. Acetic Acid,3-dichloro-4-(2-methylenebutyryl)phenoxy]-

    190. 2,3-dichloro-4-(2-methylenebutyryl)phenoxy)acetate

    191. 4-(methylenebutyryl)-2,3-dichlorophenoxy)acetic Acid

    192. Acetic Acid,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-

    193. Ethacrynic Acid, European Pharmacopoeia (ep) Reference Standard

    194. Ethacrynic Acid, United States Pharmacopeia (usp) Reference Standard

    195. 2-(2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic Acid

    196. Etacrynic Acid For System Suitability, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 303.13 g/mol
    Molecular Formula C13H12Cl2O4
    XLogP33.8
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass302.0112642 g/mol
    Monoisotopic Mass302.0112642 g/mol
    Topological Polar Surface Area63.6 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity370
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameEdecrin
    PubMed HealthEthacrynic Acid (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelEthacrynic acid is an unsaturated ketone derivative of an aryloxyace -tic acid. It is designated chemically as [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy] acetic acid, and has a molecular weight of 303.14. Ethacrynic acid is a white, or practica...
    Active IngredientEthacrynate sodium; Ethacrynic acid
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength25mg; eq 50mg base/vial
    Market StatusPrescription
    CompanyAton

    2 of 2  
    Drug NameEdecrin
    PubMed HealthEthacrynic Acid (By mouth)
    Drug ClassesCardiovascular Agent
    Drug LabelEthacrynic acid is an unsaturated ketone derivative of an aryloxyace -tic acid. It is designated chemically as [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy] acetic acid, and has a molecular weight of 303.14. Ethacrynic acid is a white, or practica...
    Active IngredientEthacrynate sodium; Ethacrynic acid
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength25mg; eq 50mg base/vial
    Market StatusPrescription
    CompanyAton

    4.2 Therapeutic Uses

    Diuretics

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    A major use of loop diuretics is in the treatment of acute pulmonary edema. A rapid incr in venous capacitance in conjunction with a brisk natriuresis reduces left ventricular filling pressures and thereby rapidly relieves pulmonary edema. Loop diuretics also are widely used for the treatment of chronic congestive heart failure when diminution of extracellular fluid volume is desirable to minimize venous and pulmonary congestion. Diuretics are widely used for the treatment of hypertension, and controlled clinical trials demonstrating reduced morbidity and mortality have been conducted with Na+-Cl- symport (thiazides and thiazide-like diuretics), but not Na+-K+-2Cl- symport, inhibitors. Nonetheless, Na+-K+-2Cl- symport inhibitors appear to lower blood pressure as effectively as Na+-Cl- symport inhibitors while causing smaller perturbations in the lipid profile. /Loop diuretics/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 773

    The edema of nephrotic syndrome often is refractory to other classes of diuretics, and loop diuretics often are the only drugs capable of reducing the massive edema associated with this renal disease. Loop diuretics also are employed in the treatment of edema and ascites of liver cirrhosis; however, care must be taken not to induce encephalopathy or hepatorenal syndrome. In patients with a drug overdose, loop diuretics can be used to induce a forced diuresis to facilitate more rapid renal elimination of the offending drug. /Loop diuretics/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 773

    Loop diuretics- combined with isotonic saline admin to prevent volume depletion- are used to treat hypercalcemia. Loop diuretics interfere with the kidney's ability to produce a concentrated urine. Consequently, loop diuretics combined with hypertonic saline are useful for the treatment of life-threatening hyponatremia. /Loop diuretics/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 773

    For more Therapeutic Uses (Complete) data for ETHACRYNIC ACID (10 total), please visit the HSDB record page.

    4.3 Drug Warning

    Vet: Rapid ototoxicity in cats. Do not admin in cases of decr renal function.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 203

    Not recommended for routine use /in pregnancy/. /Loop diuretics/

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1230

    Geriatric patients may be more sensitive to the effects of the usual adult dose.

    MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 1232

    Ethacrynic acid may cause adverse GI effects, including anorexia, abdominal discomfort or pain, nausea, vomiting, malaise, diarrhea, and dysphagia. Adverse GI effects occur most frequently when large doses are employed or after 1-3 months of continuous therapy and may necessitate discontinuing the drug. Severe, profuse, watery diarrhea may occur; the drug should be permanently discontinued if this occurs. GI bleeding has been reported, most frequently in patients receiving IV ethacrynate sodium therapy and especially in patients receiving heparin sodium concomitiantly. Acute necrotizing pancreatitis, with an incr in serum amylase, has been reported.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2564

    For more Drug Warnings (Complete) data for ETHACRYNIC ACID (16 total), please visit the HSDB record page.

    4.4 Drug Indication

    For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid accumulation. Water and electrolyte excretion may be increased several times over that observed with thiazide diuretics, since ethacrynic acid inhibits reabsorption of a much greater proportion of filtered sodium than most other diuretic agents. Therefore, ethacrynic acid is effective in many patients who have significant degrees of renal insufficiency. Ethacrynic acid has little or no effect on glomerular filtration or on renal blood flow, except following pronounced reductions in plasma volume when associated with rapid diuresis.

    5.2 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    ETHACRYNIC ACID
    5.3.2 FDA UNII
    M5DP350VZV
    5.3.3 Pharmacological Classes
    Loop Diuretic [EPC]; Increased Diuresis at Loop of Henle [PE]
    5.4 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03C - High-ceiling diuretics

    C03CC - Aryloxyacetic acid derivatives

    C03CC01 - Etacrynic acid

    5.5 Absorption, Distribution and Excretion

    Absorption

    Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.

    Thirty-five % or less of ethacrynic acid was excreted in urine of rats and dogs, regardless of mode of admin and 50% or more appeared in feces, suggesting hepatic elimination of the drug.

    PMID:4427293 Klaasen CD, Fitzgerald TJ; J Pharmacol Exp Ther 191: 548 (1974)

    Renal elimination (67%), biliary/fecal (33%), 20% unchanged. /From table/

    Ford MD, Delaney KA, Ling LJ, Erickson T; Clinical Toxicology. W.B. Saunders Company., Philadelphia, PA. 2001, p. 398

    Ethacrynic acid is rapidly absorbed from the GI tract. Following oral admin, the diuretic effect occurs within 30 min and reaches a peak in approx 2 hr. The duration of action following oral admin is usually 6-8 hr but may continue up to 12 hr. Following IV admin of ethacrynate sodium, diuresis usually occurs within 5 min, reached a max within 15-30 min, and persists for approx 2 hr. In animals, substantial quantities of ethacrynic acid accumulate only in the liver. The drug does not enter the CSF. It is not known whether ethacrynic acid crosses the placenta or is distributed into milk in humans. ... Approx 30-65% of an IV dose of ethacrynate sodium is secreted by the proximal renal tubules and is excreted in urine; approx 35-40% is excreted in bile, partially as the cysteine conjugate. In dogs, approx 30-40% of the drug excreted in urine is unchanged, 20-30% is the cysteine conjugate, and 33-40% is an unstable, unidentified compound. The rate of urinary excretion of ethacrynic acid increases as urinary pH increases and is decreased by probenecid.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2566

    5.6 Metabolism/Metabolites

    Hepatic.

    After iv admin (5 or 50 mg/kg) of (14)C-ethacrynic acid to rats 60-70% was excreted into bile within 4 hr; <25% was ethacrynic acid, the remainder was biotransformation products. The 2 major metabolites in bile were identified; one was the glutathione adduct (ethacrynic acid-GSH) and the other was ethacrynic acid-mercapturate. Approx 40% of either dose was excreted as ethacrynic acid-GSH. Ethacrynic acid-mercapturate accounted for 18% of the low dose and 30% of the high dose excreted into bile. Dogs given a 5 mg/kg dose (iv) excreted 25, 11, and 9% of the dose as ethacrynic acid-mercapturate, ethacrynic acid-cysteine and ethacrynic acid-GSH, respectively.

    PMID:4427293 Klaasen CD, Fitzgerald TJ; J Pharmacol Exp Ther 191: 548 (1974)

    Animal studies indicate that ethacrynic acid is metabolized to a cysteine conjugate (which may contribute to the pharmacologic effects of the drug) and to an unstable, unidentified compound.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2566

    5.7 Mechanism of Action

    Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma and extracellular fluid volume; cardiac output also decreases, explaining its antihypertensive action. Eventually, cardiac output returns to normal with an accompanying decrease in peripheral resistance. Its mode of action does not involve carbonic anhydrase inhibition.

    Optimal diuretic activity depends on at least 2 structural requirements: (1) methylene and adjacent ketone groups capable of reacting with sulfhydryl radicals of presumed receptor, and (2) substituents on aromatic nucleus.

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 903

    In vitro, ethacrynic acid inhibits the active transport of chloride in the lumen of the ascending limb of the loop of Henle, thereby diminishing reabsorption of sodium and chloride at that site. Because this inhibition occurred with lower concns of ethacrynic acid in the presence of cysteine, it has been proposed that the ethacrynate-cysteine metabolite is the most active form of the drug. The drug increases potassium excretion in the distal renal tubule. Ethacrynic acid does not inhibit carbonic anhydrase, and it is not an aldosterone antagonist. Aldosterone secretion may incr during therapy with the drug and may contribute to the hypokalemia caused by ethacrynic acid.

    McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2565

    ...IRREVERSIBLY COMBINES WITH 2 THIOL GROUPS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, THUS INACTIVATING THE ENZYME. HOWEVER, IT IS NOT POSSIBLE TO ATTRIBUTE DIURETIC ACTION TO THIS TYPE OF BIOCHEMICAL REACTION...

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 905

    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"ETHACRYNIC ACID","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"ETHACRYNIC ACID (TAX INVOICE NO:EXPORT 123\/2020-21 DT:23.03.2021","address":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"MINNEAPOLIS METROPO","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"12.80","actualQuantity":"12.8","unit":"KGS","unitRateFc":"2954","totalValueFC":"37420.3","currency":"USD","unitRateINR":212831.875,"date":"26-Mar-2021","totalValueINR":"2724248","totalValueInUsd":"37420.3","indian_port":"HYDERABAD AIR","hs_no":"29332990","bill_no":"9675281","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1656009000,"product":"ETHACRYNIC ACID","address":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,","city":"HYDERABAD,TELANGANA","supplier":"VIATRIS","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"INGENUS PHARMACEUTICALS","customerCountry":"UNITED STATES","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"8000","totalValueFC":"62821","currency":"USD","unitRateINR":612625,"date":"24-Jun-2022","totalValueINR":"4901000","totalValueInUsd":"62821","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"2365802","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"564\/A\/22, ROAD NO. 92,JUBILEE HILL S,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1663785000,"product":"ETHACRYNIC ACID (TAX INVOICE NO:SPP2223","address":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"6.50","actualQuantity":"6.5","unit":"KGS","unitRateFc":"3000","totalValueFC":"18941.6","currency":"USD","unitRateINR":233538.46153846153,"date":"22-Sep-2022","totalValueINR":"1518000","totalValueInUsd":"18941.6","indian_port":"HYDERABAD AIR","hs_no":"29332990","bill_no":"4360532","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY, VISAKHAPATNAM,ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708453800,"product":"ETHACRYNIC ACID (TAX INVOICE NO:SPP2324U1ES-112, DT:17.02.2024)","address":"43-11-56, SUBBALAKSHMI NAGAR","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"MINNEAPOLIS METROPO","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"12.89","actualQuantity":"12.89","unit":"KGS","unitRateFc":"3000","totalValueFC":"38067","currency":"USD","unitRateINR":245039.79829325058,"date":"21-Feb-2024","totalValueINR":"3158563","totalValueInUsd":"38067","indian_port":"Hyderabad Air","hs_no":"29332990","bill_no":"7715601","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710786600,"product":"ETHACRYNIC ACID","address":"43-11-56, SUBBALAKSHMI NAGAR","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. 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    29-Jan-2021
    23-Jan-2025
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    ABOUT THIS PAGE

    Looking for 58-54-8 / Ethacrynic Acid API manufacturers, exporters & distributors?

    Ethacrynic Acid manufacturers, exporters & distributors 1

    21

    PharmaCompass offers a list of Ethacrynic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ethacrynic Acid manufacturer or Ethacrynic Acid supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ethacrynic Acid manufacturer or Ethacrynic Acid supplier.

    PharmaCompass also assists you with knowing the Ethacrynic Acid API Price utilized in the formulation of products. Ethacrynic Acid API Price is not always fixed or binding as the Ethacrynic Acid Price is obtained through a variety of data sources. The Ethacrynic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ethacrynic Acid

    Synonyms

    Etacrynic acid, 58-54-8, Ethacrynate, Edecrin, Etacrinic acid, Hydromedin

    Cas Number

    58-54-8

    Unique Ingredient Identifier (UNII)

    M5DP350VZV

    About Ethacrynic Acid

    A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

    Ethacrynic Acid Manufacturers

    A Ethacrynic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ethacrynic Acid, including repackagers and relabelers. The FDA regulates Ethacrynic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ethacrynic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ethacrynic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ethacrynic Acid Suppliers

    A Ethacrynic Acid supplier is an individual or a company that provides Ethacrynic Acid active pharmaceutical ingredient (API) or Ethacrynic Acid finished formulations upon request. The Ethacrynic Acid suppliers may include Ethacrynic Acid API manufacturers, exporters, distributors and traders.

    click here to find a list of Ethacrynic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ethacrynic Acid USDMF

    A Ethacrynic Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Ethacrynic Acid active pharmaceutical ingredient (API) in detail. Different forms of Ethacrynic Acid DMFs exist exist since differing nations have different regulations, such as Ethacrynic Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ethacrynic Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Ethacrynic Acid USDMF includes data on Ethacrynic Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ethacrynic Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ethacrynic Acid suppliers with USDMF on PharmaCompass.

    Ethacrynic Acid CEP

    A Ethacrynic Acid CEP of the European Pharmacopoeia monograph is often referred to as a Ethacrynic Acid Certificate of Suitability (COS). The purpose of a Ethacrynic Acid CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ethacrynic Acid EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ethacrynic Acid to their clients by showing that a Ethacrynic Acid CEP has been issued for it. The manufacturer submits a Ethacrynic Acid CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ethacrynic Acid CEP holder for the record. Additionally, the data presented in the Ethacrynic Acid CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ethacrynic Acid DMF.

    A Ethacrynic Acid CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ethacrynic Acid CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ethacrynic Acid suppliers with CEP (COS) on PharmaCompass.

    Ethacrynic Acid WC

    A Ethacrynic Acid written confirmation (Ethacrynic Acid WC) is an official document issued by a regulatory agency to a Ethacrynic Acid manufacturer, verifying that the manufacturing facility of a Ethacrynic Acid active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ethacrynic Acid APIs or Ethacrynic Acid finished pharmaceutical products to another nation, regulatory agencies frequently require a Ethacrynic Acid WC (written confirmation) as part of the regulatory process.

    click here to find a list of Ethacrynic Acid suppliers with Written Confirmation (WC) on PharmaCompass.

    Ethacrynic Acid NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ethacrynic Acid as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ethacrynic Acid API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ethacrynic Acid as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ethacrynic Acid and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ethacrynic Acid NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ethacrynic Acid suppliers with NDC on PharmaCompass.

    Ethacrynic Acid GMP

    Ethacrynic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ethacrynic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ethacrynic Acid GMP manufacturer or Ethacrynic Acid GMP API supplier for your needs.

    Ethacrynic Acid CoA

    A Ethacrynic Acid CoA (Certificate of Analysis) is a formal document that attests to Ethacrynic Acid's compliance with Ethacrynic Acid specifications and serves as a tool for batch-level quality control.

    Ethacrynic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Ethacrynic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ethacrynic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Ethacrynic Acid EP), Ethacrynic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ethacrynic Acid USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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