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Chemistry

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Also known as: 189954-96-9, Equioxx, Previcox, Librens, Ml 1785713, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one
Molecular Formula
C17H20O5S
Molecular Weight
336.4  g/mol
InChI Key
FULAPETWGIGNMT-UHFFFAOYSA-N
FDA UNII
Y6V2W4S4WT

Firocoxib
Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.
1 2D Structure

Firocoxib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
2.1.2 InChI
InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
2.1.3 InChI Key
FULAPETWGIGNMT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C
2.2 Other Identifiers
2.2.1 UNII
Y6V2W4S4WT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

2. Equioxx

3. Ml 1,785,713

4. Ml 1785713

5. Ml-1,785,713

6. Ml-1785713

7. Ml1,785,713

8. Ml1785713

2.3.2 Depositor-Supplied Synonyms

1. 189954-96-9

2. Equioxx

3. Previcox

4. Librens

5. Ml 1785713

6. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

7. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one

8. Ml-1,785,713

9. Nsc-758895

10. Y6v2w4s4wt

11. Chembl69998

12. Chebi:76136

13. Firocoxib (ema Epar: Veterinary)

14. Equixx

15. Ml-1785713

16. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

17. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-

18. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-

19. 3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one

20. Firocoxib [usan:inn]

21. Unii-y6v2w4s4wt

22. Firocoxibum

23. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5h)-furanone

24. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5h)-one

25. Firocoxib [inn]

26. Firocoxib [mi]

27. Firocoxib (usan/inn)

28. Firocoxib [usan]

29. Firocoxib [mart.]

30. Equioxx (tn) [veterinary]

31. Firocoxib [green Book]

32. Amy378

33. Schembl1383179

34. Dtxsid40870188

35. Hms3264g15

36. Pharmakon1600-01504526

37. Bcp07253

38. Zinc3623447

39. Bdbm50080082

40. Nsc758895

41. Ccg-213396

42. Cs-3419

43. Db09217

44. Nsc 758895

45. Ncgc00389572-01

46. Ncgc00389572-02

47. Ac-33540

48. As-73802

49. Hy-14670

50. Sbi-0206717.p001

51. Ft-0668544

52. Firocoxib, Vetranal(tm), Analytical Standard

53. C18363

54. C73637

55. D03712

56. Ab01563063_01

57. 954f969

58. A918990

59. Sr-01000872758

60. J-012265

61. Q2034390

62. Sr-01000872758-1

63. 3-(cyclopropylmethoxy)-4-(4-methylsulfonyl)phenyl)-5,5-dimethylfuranone

64. 3-(cyclopropylmethoxy)-4-[4-(methanesulfonyl)phenyl]-5,5-dimethylfuran-2(5h)-one

65. 3-cyclopropylmethoxy-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5h-furan-2-one

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 336.4 g/mol
Molecular Formula C17H20O5S
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass336.10314491 g/mol
Monoisotopic Mass336.10314491 g/mol
Topological Polar Surface Area78 Ų
Heavy Atom Count23
Formal Charge0
Complexity614
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used for the treatment of pain inflammation and fever in horses and dogs.


* Tablets:

For the relief of pain and inflammation associated with osteoarthritis in dogs.

For the relief of postoperative pain and inflammation associated with soft-tissue, orthopaedic and dental surgery in dogs.

* Oral paste:

Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.


Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.


5 Pharmacology and Biochemistry
5.1 ATC Code

QM01AH90


QM01AH90


API Reference Price

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23-Feb-2023
15-May-2024
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API | Excipient name

Firocoxib

Synonyms

189954-96-9, Equioxx, Previcox, Librens, Ml 1785713, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

Cas Number

189954-96-9

Unique Ingredient Identifier (UNII)

Y6V2W4S4WT

About Firocoxib

Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.

Equioxx Manufacturers

A Equioxx manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Equioxx, including repackagers and relabelers. The FDA regulates Equioxx manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Equioxx API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Equioxx manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Equioxx Suppliers

A Equioxx supplier is an individual or a company that provides Equioxx active pharmaceutical ingredient (API) or Equioxx finished formulations upon request. The Equioxx suppliers may include Equioxx API manufacturers, exporters, distributors and traders.

click here to find a list of Equioxx suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Equioxx NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Equioxx as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Equioxx API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Equioxx as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Equioxx and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Equioxx NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Equioxx suppliers with NDC on PharmaCompass.

Equioxx GMP

Equioxx Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Equioxx GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Equioxx GMP manufacturer or Equioxx GMP API supplier for your needs.

Equioxx CoA

A Equioxx CoA (Certificate of Analysis) is a formal document that attests to Equioxx's compliance with Equioxx specifications and serves as a tool for batch-level quality control.

Equioxx CoA mostly includes findings from lab analyses of a specific batch. For each Equioxx CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Equioxx may be tested according to a variety of international standards, such as European Pharmacopoeia (Equioxx EP), Equioxx JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Equioxx USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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