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Chemistry

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Also known as: Kifgslafl, 160212-35-1, Neuvax, Neuvax vaccine, L-lysyl-l-isoleucyl-l-phenylalanylglycyl-l-seryl-l-leucyl-l-alanyl-l-phenylalanyl-l-leucine, Nelipepimut-s [usan]
Molecular Formula
C50H78N10O11
Molecular Weight
995.2  g/mol
InChI Key
AHOKKYCUWBLDST-QYULHYBRSA-N

Nelipepimut-S
Nelipepimut-S is a cancer vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted HER2/neu (human epidermal growth factor receptor 2; ErbB2) nonapeptide derived from the extracellular domain of the HER2 protein, with potential immunomodulating and antineoplastic activities. Upon intradermal injection, nelipepimut-S may induce a specific cytotoxic T-lymphocyte (CTL) response against HER2/neu-expressing tumor cells. HER2/neu, a tumor-associated antigen and a member of the epidermal growth factor receptor family of tyrosine kinases, is overexpressed in various tumor cell types and plays a key role in tumorigenesis.
1 2D Structure

Nelipepimut-S

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
2.1.2 InChI
InChI=1S/C50H78N10O11/c1-8-31(6)42(60-44(64)35(52)21-15-16-22-51)49(69)58-37(25-33-17-11-9-12-18-33)45(65)53-27-41(62)55-40(28-61)48(68)57-36(23-29(2)3)46(66)54-32(7)43(63)56-38(26-34-19-13-10-14-20-34)47(67)59-39(50(70)71)24-30(4)5/h9-14,17-20,29-32,35-40,42,61H,8,15-16,21-28,51-52H2,1-7H3,(H,53,65)(H,54,66)(H,55,62)(H,56,63)(H,57,68)(H,58,69)(H,59,67)(H,60,64)(H,70,71)/t31-,32-,35-,36-,37-,38-,39-,40-,42-/m0/s1
2.1.3 InChI Key
AHOKKYCUWBLDST-QYULHYBRSA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CCCCN)N
2.1.5 Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCCCN)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. E75 Her2 Peptide

2. Her2 (369-377)

3. Her2 Peptide (369-377)

4. Nelipepimut-5

2.2.2 Depositor-Supplied Synonyms

1. Kifgslafl

2. 160212-35-1

3. Neuvax

4. Neuvax Vaccine

5. L-lysyl-l-isoleucyl-l-phenylalanylglycyl-l-seryl-l-leucyl-l-alanyl-l-phenylalanyl-l-leucine

6. Nelipepimut-s [usan]

7. Unii-7m0a29cd8b

8. E75 Peptide

9. 7m0a29cd8b

10. Chembl386200

11. Dtxsid80166835

12. Bdbm50409332

13. E-75

14. Her-2(369-377)

15. Hy-106204

16. Cs-0025241

17. Q27268544

18. (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic Acid

19. Human Receptor Tyrosine-protein Kinase Erbb-2 (proto-oncogene Neu, Tyrosine Kinase- Type Cell Surface Receptor Her2, Cd340)-(347-355)-peptide

2.3 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 995.2 g/mol
Molecular Formula C50H78N10O11
XLogP30.4
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count13
Rotatable Bond Count32
Exact Mass994.58515334 g/mol
Monoisotopic Mass994.58515334 g/mol
Topological Polar Surface Area342 Ų
Heavy Atom Count71
Formal Charge0
Complexity1720
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in prostate cancer and breast cancer.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

NeuVax is a HER2/neu peptide-based T-cell immunotherapy aimed at preventing disease recurrence and prolonging survival in cancer patients that have tumors which express the HER2/neu oncoprotein. To date, clinical study results have demonstrated that NeuVax significantly reduces the rate of cancer recurrence while showing minimal side effects. [Apthera Press release]


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Looking for 160212-35-1 / Nelipepimut-S API manufacturers, exporters & distributors?

Nelipepimut-S manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Nelipepimut-S API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Nelipepimut-S manufacturer or Nelipepimut-S supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Nelipepimut-S manufacturer or Nelipepimut-S supplier.

PharmaCompass also assists you with knowing the Nelipepimut-S API Price utilized in the formulation of products. Nelipepimut-S API Price is not always fixed or binding as the Nelipepimut-S Price is obtained through a variety of data sources. The Nelipepimut-S Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Nelipepimut-S

Synonyms

Kifgslafl, 160212-35-1, Neuvax, Neuvax vaccine, L-lysyl-l-isoleucyl-l-phenylalanylglycyl-l-seryl-l-leucyl-l-alanyl-l-phenylalanyl-l-leucine, Nelipepimut-s [usan]

Cas Number

160212-35-1

About Nelipepimut-S

Nelipepimut-S is a cancer vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted HER2/neu (human epidermal growth factor receptor 2; ErbB2) nonapeptide derived from the extracellular domain of the HER2 protein, with potential immunomodulating and antineoplastic activities. Upon intradermal injection, nelipepimut-S may induce a specific cytotoxic T-lymphocyte (CTL) response against HER2/neu-expressing tumor cells. HER2/neu, a tumor-associated antigen and a member of the epidermal growth factor receptor family of tyrosine kinases, is overexpressed in various tumor cell types and plays a key role in tumorigenesis.

E75 peptide Manufacturers

A E75 peptide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of E75 peptide, including repackagers and relabelers. The FDA regulates E75 peptide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. E75 peptide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

E75 peptide Suppliers

A E75 peptide supplier is an individual or a company that provides E75 peptide active pharmaceutical ingredient (API) or E75 peptide finished formulations upon request. The E75 peptide suppliers may include E75 peptide API manufacturers, exporters, distributors and traders.

E75 peptide GMP

E75 peptide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of E75 peptide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right E75 peptide GMP manufacturer or E75 peptide GMP API supplier for your needs.

E75 peptide CoA

A E75 peptide CoA (Certificate of Analysis) is a formal document that attests to E75 peptide's compliance with E75 peptide specifications and serves as a tool for batch-level quality control.

E75 peptide CoA mostly includes findings from lab analyses of a specific batch. For each E75 peptide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

E75 peptide may be tested according to a variety of international standards, such as European Pharmacopoeia (E75 peptide EP), E75 peptide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (E75 peptide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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