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1. (-5alpha, 11alpha,13s)-13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3-ol
2. 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecenol
3. 5,11-methanobenzocyclodecen-3-ol, 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5alpha,11alpha,13s*)
4. Dezocine Hydrobromide, (5alpha,11alpha,13*)-isomer
5. Dezocine Hydrobromide, (5alpha,11alpha,13s*)-isomer
6. Dezocine Hydrobromide, (5r-(5alpha,11alpha,13s*))-isomer
7. Dezocine Hydrobromide, (5s-(5alpha,11alpha,13*))-isomer
8. Dezocine, (5alpha,11alpha,13s*)-isomer
9. Wy-16,225
1. Dalgan
2. 53648-55-8
3. Dezocina
4. Dezocinum
5. Docozine
6. Dozocine
7. Dezocinum [inn-latin]
8. Dezocina [inn-spanish]
9. Wy-16225
10. Vhx8k5sv4x
11. Wy-16,225
12. Chembl1685
13. Chebi:4474
14. Dezocine (usan)
15. (-)-13beta-amino-5,6,7,8,9,10,11alpha,12-octahydro-5alpha-methyl-5,11-methanobenzocyclodecen-3-ol
16. Dezocine [usan]
17. (1r,9s,15s)-15-amino-1-methyltricyclo[7.5.1.02,7]pentadeca-2(7),3,5-trien-4-ol
18. Dezocine [usan:inn]
19. Unii-vhx8k5sv4x
20. Dalgan (tn)
21. Wy 16225
22. Dezocine [inn]
23. Dezocine [mi]
24. Wy 16,225
25. Dezocine [vandf]
26. Dezocine [mart.]
27. Dezocine [who-dd]
28. Schembl3072
29. Dezocine [orange Book]
30. Dtxsid2022911
31. (5r,11s,13s)-13-amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzo[10]annulen-3-ol
32. Bdbm50276568
33. Akos016014025
34. Db01209
35. C08010
36. D00838
37. Q1109018
38. (1r,9s,15s)-15-amino-1-methyltricyclo[7.5.1.0^{2,7}]pentadeca-2,4,6-trien-4-ol
39. 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecenol
40. (-)-13.beta.-amino-5,6,7,8,9,10,11.alpha.,12-octahydro-5.alpha.-methyl-5,11-methanobenzocyclodecen-3-ol
41. (5r,11s,13s)-13-amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzocyclodecen-3-ol
42. 5,11-methanobenzocyclodecen-3-ol, 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5.alpha.,11.alpha.,13s*)
43. 5,11-methanobenzocyclodecen-3-ol, 13-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-, (5alpha,11alpha,13s*)-, (-)-
Molecular Weight | 245.36 g/mol |
---|---|
Molecular Formula | C16H23NO |
XLogP3 | 3.7 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 0 |
Exact Mass | 245.177964357 g/mol |
Monoisotopic Mass | 245.177964357 g/mol |
Topological Polar Surface Area | 46.2 Ų |
Heavy Atom Count | 18 |
Formal Charge | 0 |
Complexity | 306 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 3 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Indicated in the treatment of moderate to severe pain.
Dezocine is a parenteral narcotic analgesic possessing both agonist and antagonist activity. It is similar to morphine with respect to analgesic potency and onset and duration of action. The narcotic antagonist activity is greater than that of pentazocine.
Analgesics, Opioid
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)
N - Nervous system
N02 - Analgesics
N02A - Opioids
N02AX - Other opioids
N02AX03 - Dezocine
Absorption
Rapid and complete following intramuscular administration.
Hepatic, via conjugation (glucuronidation).
Dezocine has known human metabolites that include Dezocine glucuronide.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
Elimination half-life following intramuscular administration averages 2.2 hours. Elimination half-life following a 5mg intravenous dose averages 1.7 to 2.6 hours (range 0.6 to 4.4 hours) while a 10mg dose averages 2.4 to 2.6 hours (range 1.2 to 7.4 hours). In patients with hepatic cirrhosis, the half-life is increased by 30 to 50%.
Dezocine is a opioid analgesic drug of mixed agonist-antagonist type. It binds with stereospecific receptors at many sites within the central nervous system (CNS) to alter processes affecting both the perception of pain and the emotional response to pain. At least 2 of these types of receptors (mu and kappa) mediate analgesia. Mu receptors are widely distributed throughout the CNS, especially in the limbic system (frontal cortex, temporal cortex, amygdala, and hippocampus), thalamus, striatum, hypothalamus, and midbrain as well as laminae I, II, IV, and V of the dorsal horn in the spinal cord. Kappa receptors are localized primarily in the spinal cord and in the cerebral cortex.
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PharmaCompass offers a list of Dezocine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Dezocine manufacturer or Dezocine supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Dezocine manufacturer or Dezocine supplier.
PharmaCompass also assists you with knowing the Dezocine API Price utilized in the formulation of products. Dezocine API Price is not always fixed or binding as the Dezocine Price is obtained through a variety of data sources. The Dezocine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Dezocina manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dezocina, including repackagers and relabelers. The FDA regulates Dezocina manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dezocina API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Dezocina manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Dezocina supplier is an individual or a company that provides Dezocina active pharmaceutical ingredient (API) or Dezocina finished formulations upon request. The Dezocina suppliers may include Dezocina API manufacturers, exporters, distributors and traders.
click here to find a list of Dezocina suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Dezocina DMF (Drug Master File) is a document detailing the whole manufacturing process of Dezocina active pharmaceutical ingredient (API) in detail. Different forms of Dezocina DMFs exist exist since differing nations have different regulations, such as Dezocina USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Dezocina DMF submitted to regulatory agencies in the US is known as a USDMF. Dezocina USDMF includes data on Dezocina's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dezocina USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Dezocina suppliers with USDMF on PharmaCompass.
Dezocina Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Dezocina GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dezocina GMP manufacturer or Dezocina GMP API supplier for your needs.
A Dezocina CoA (Certificate of Analysis) is a formal document that attests to Dezocina's compliance with Dezocina specifications and serves as a tool for batch-level quality control.
Dezocina CoA mostly includes findings from lab analyses of a specific batch. For each Dezocina CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Dezocina may be tested according to a variety of international standards, such as European Pharmacopoeia (Dezocina EP), Dezocina JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dezocina USP).