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    Chemistry

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    Also known as: Ciprofloxacin hcl, 93107-08-5, 86483-48-9, 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, Cipro, Chebi:310388
    Molecular Formula
    C17H19ClFN3O3
    Molecular Weight
    367.8  g/mol
    InChI Key
    DIOIOSKKIYDRIQ-UHFFFAOYSA-N
    FDA UNII
    0MP32MFP6C
    Ciprofloxacin Hydrochloride
    A broad-spectrum antimicrobial carboxyfluoroquinoline.
    1 2D Structure

    Ciprofloxacin Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
    2.1.3 InChI Key
    DIOIOSKKIYDRIQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0MP32MFP6C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anhydrous, Ciprofloxacin Hydrochloride

    2. Bay 09867

    3. Bay-09867

    4. Bay09867

    5. Ciprinol

    6. Cipro

    7. Ciprofloxacin

    8. Ciprofloxacin Hydrochloride Anhydrous

    9. Ciprofloxacin Monohydrochloride Monohydrate

    10. Hydrochloride Anhydrous, Ciprofloxacin

    11. Hydrochloride, Ciprofloxacin

    12. Monohydrate, Ciprofloxacin Monohydrochloride

    13. Monohydrochloride Monohydrate, Ciprofloxacin

    2.3.2 Depositor-Supplied Synonyms

    1. Ciprofloxacin Hcl

    2. 93107-08-5

    3. 86483-48-9

    4. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

    5. Cipro

    6. Chebi:310388

    7. Ciprofloxacin Hydrochloride Anhydrous

    8. 0mp32mfp6c

    9. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hydrochloride

    10. Ciprofloxacin (monohydrochloride)

    11. Bay-o-9867

    12. Ciprofloxacin Hydrochloride (anh.)

    13. Bay O 9867

    14. Cetraxal

    15. Ciprobay

    16. Ciproxan

    17. Ciproxin

    18. Flociprin

    19. Ciflox

    20. Mfcd00079044

    21. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hcl

    22. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic Acid;hydrochloride

    23. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Xhydrochloride

    24. Bay-o 9867

    25. 93107-08-5 (hcl)

    26. 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic Acid Hydrochloride

    27. Dsstox_cid_27768

    28. Dsstox_rid_82545

    29. Dsstox_gsid_47788

    30. Ciprofloxacin (as Hydrochloride)

    31. Prestwick_67

    32. 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic Acid; Hydrochloride

    33. 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinolin-7-yl)-piperazin-1-ium; Chloride

    34. Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride

    35. Nsc620634

    36. Ciprofloxacin Hydrochloride (anhydrous)

    37. Ciprofloxacin 100 Microg/ml In Methanol

    38. Ncgc00016959-01

    39. Cas-93107-08-5

    40. Unii-0mp32mfp6c

    41. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

    42. 3-quiolinecarboxylic Acid

    43. Ciprofloxacine Hydrochloride

    44. Epitope Id:174846

    45. Cambridge Id 5807784

    46. Ciprofloxacini Hydrochloridum

    47. Chembl1202

    48. Schembl42310

    49. 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Monohydrochloride

    50. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Monohydrochloride

    51. Ciprofloxacin Hcl/lactate

    52. Dtxsid1047788

    53. Hy-b0356a

    54. Ciprofloxacin Hydrochloride (1:x)

    55. Hms1568g08

    56. Bcp13634

    57. Bcp14336

    58. Tox21_110712

    59. S5008

    60. Akos005111008

    61. Tox21_110712_1

    62. Cs-8134

    63. Ks-5012

    64. Nsc-620634

    65. Sb73037

    66. Ncgc00016959-06

    67. 3-quinolinecarboxylic Acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, Hydrochloride

    68. Ac-23972

    69. Bim-0048462.p001

    70. Ciprofloxacin 1000 Microg/ml In Methanol

    71. Ciprofloxacin Hydrochloride [who-dd]

    72. Ft-0623850

    73. Ft-0623851

    74. A16969

    75. H10663

    76. A859872

    77. Q-200860

    78. Q27105154

    79. F0001-2378

    80. Cpx; Cetraxal; Ciloxan; Cipro; Bay-09867 Hydrochloride

    81. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hcl

    82. 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacidxhydrochloride

    83. 3-quinolinecarboxylic Acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 367.8 g/mol
    Molecular Formula C17H19ClFN3O3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass367.1098973 g/mol
    Monoisotopic Mass367.1098973 g/mol
    Topological Polar Surface Area72.9 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity571
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCiprofloxacin hydrochloride
    PubMed HealthCiprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
    Drug ClassesAntibacterial
    Drug LabelCiprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
    Active IngredientCiprofloxacin hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strengtheq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
    Market StatusPrescription
    CompanyWatson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

    2 of 2  
    Drug NameCiprofloxacin hydrochloride
    PubMed HealthCiprofloxacin Betaine/Ciprofloxacin Hydrochloride (By mouth)
    Drug ClassesAntibacterial
    Drug LabelCiprofloxacin Tablets, USPis a synthetic broad spectrum antimicrobial agent for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-pip...
    Active IngredientCiprofloxacin hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strengtheq 100mg base; eq 750mg base; eq 500mg base; eq 0.3% base; eq 250mg base
    Market StatusPrescription
    CompanyWatson Labs; Nexus Pharms; Ranbaxy; Ivax Sub Teva Pharms; Apotex; Bausch And Lomb; Aurobindo Pharma; Taro; Dr Reddys Labs; Unique Pharm Labs; Carlsbad; Pharmaforce; Fdc; Mylan; Hikma; Akorn

    4.2 Drug Indication

    Treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Topoisomerase II Inhibitors

    Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

    Cytochrome P-450 CYP1A2 Inhibitors

    Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Quinolones [CS]; Quinolone Antimicrobial [EPC]

    API Reference Price

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    06-Jan-2021
    28-Mar-2025
    KGS
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% ...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - EQ 0.3% BASE

    USFDA APPLICATION NUMBER - 19992

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    DOSAGE - OINTMENT;OPHTHALMIC - EQ 0.3% BASE

    USFDA APPLICATION NUMBER - 20369

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    DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE...DOSAGE - SUSPENSION/DROPS;OTIC - EQ 0.2% BASE;1%

    USFDA APPLICATION NUMBER - 20805

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    ABOUT THIS PAGE

    Looking for 86483-48-9 / Ciprofloxacin Hydrochloride API manufacturers, exporters & distributors?

    Ciprofloxacin Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Ciprofloxacin Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ciprofloxacin Hydrochloride manufacturer or Ciprofloxacin Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ciprofloxacin Hydrochloride manufacturer or Ciprofloxacin Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Ciprofloxacin Hydrochloride API Price utilized in the formulation of products. Ciprofloxacin Hydrochloride API Price is not always fixed or binding as the Ciprofloxacin Hydrochloride Price is obtained through a variety of data sources. The Ciprofloxacin Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ciprofloxacin Hydrochloride

    Synonyms

    Ciprofloxacin hcl, 93107-08-5, 86483-48-9, 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, Cipro, Chebi:310388

    Cas Number

    86483-48-9

    Unique Ingredient Identifier (UNII)

    0MP32MFP6C

    About Ciprofloxacin Hydrochloride

    A broad-spectrum antimicrobial carboxyfluoroquinoline.

    Ciprofloxacin Hydrochloride Manufacturers

    A Ciprofloxacin Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ciprofloxacin Hydrochloride, including repackagers and relabelers. The FDA regulates Ciprofloxacin Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ciprofloxacin Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ciprofloxacin Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ciprofloxacin Hydrochloride Suppliers

    A Ciprofloxacin Hydrochloride supplier is an individual or a company that provides Ciprofloxacin Hydrochloride active pharmaceutical ingredient (API) or Ciprofloxacin Hydrochloride finished formulations upon request. The Ciprofloxacin Hydrochloride suppliers may include Ciprofloxacin Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ciprofloxacin Hydrochloride USDMF

    A Ciprofloxacin Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Ciprofloxacin Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Ciprofloxacin Hydrochloride DMFs exist exist since differing nations have different regulations, such as Ciprofloxacin Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ciprofloxacin Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Ciprofloxacin Hydrochloride USDMF includes data on Ciprofloxacin Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ciprofloxacin Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with USDMF on PharmaCompass.

    Ciprofloxacin Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Ciprofloxacin Hydrochloride Drug Master File in Japan (Ciprofloxacin Hydrochloride JDMF) empowers Ciprofloxacin Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Ciprofloxacin Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Ciprofloxacin Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with JDMF on PharmaCompass.

    Ciprofloxacin Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Ciprofloxacin Hydrochloride Drug Master File in Korea (Ciprofloxacin Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ciprofloxacin Hydrochloride. The MFDS reviews the Ciprofloxacin Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Ciprofloxacin Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Ciprofloxacin Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ciprofloxacin Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with KDMF on PharmaCompass.

    Ciprofloxacin Hydrochloride CEP

    A Ciprofloxacin Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Ciprofloxacin Hydrochloride Certificate of Suitability (COS). The purpose of a Ciprofloxacin Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ciprofloxacin Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ciprofloxacin Hydrochloride to their clients by showing that a Ciprofloxacin Hydrochloride CEP has been issued for it. The manufacturer submits a Ciprofloxacin Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ciprofloxacin Hydrochloride CEP holder for the record. Additionally, the data presented in the Ciprofloxacin Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ciprofloxacin Hydrochloride DMF.

    A Ciprofloxacin Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ciprofloxacin Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Ciprofloxacin Hydrochloride WC

    A Ciprofloxacin Hydrochloride written confirmation (Ciprofloxacin Hydrochloride WC) is an official document issued by a regulatory agency to a Ciprofloxacin Hydrochloride manufacturer, verifying that the manufacturing facility of a Ciprofloxacin Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ciprofloxacin Hydrochloride APIs or Ciprofloxacin Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Ciprofloxacin Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Ciprofloxacin Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ciprofloxacin Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ciprofloxacin Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ciprofloxacin Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ciprofloxacin Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ciprofloxacin Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ciprofloxacin Hydrochloride suppliers with NDC on PharmaCompass.

    Ciprofloxacin Hydrochloride GMP

    Ciprofloxacin Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ciprofloxacin Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ciprofloxacin Hydrochloride GMP manufacturer or Ciprofloxacin Hydrochloride GMP API supplier for your needs.

    Ciprofloxacin Hydrochloride CoA

    A Ciprofloxacin Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Ciprofloxacin Hydrochloride's compliance with Ciprofloxacin Hydrochloride specifications and serves as a tool for batch-level quality control.

    Ciprofloxacin Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Ciprofloxacin Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ciprofloxacin Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Ciprofloxacin Hydrochloride EP), Ciprofloxacin Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ciprofloxacin Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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