Bora CDMO Bora CDMO

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Find Carvedilol Phosphate manufacturers, exporters & distributors on PharmaCompass

    Client Email Product

    Carvedilol Phosphate

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Formulations

    DRUG PRODUCT COMPOSITION

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PATENTS

    DIGITAL CONTENT

    PharmaCompass
    Product SearchProduct Search
    API SUPPLIERS
    API Suppliers

    API Suppliers

    15
    US DMFs Filed

    US DMFs Filed

    9
    CEP/COS Certifications

    CEP/COS Certifications

    0

    JDMFs Filed

    JDMFs Filed

    0

    Other Certificates

    Other Certificates

    1
    Other Suppliers

    Other Suppliers

    9
    API REF. PRICE (USD / KG)
    2,424

    API Market Place

    4
    INTERMEDIATES

    0

    DOSSIERS // FDF
    USA (Orange Book)

    USA (Orange Book)

    12
    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Uploaded Dossiers

    Uploaded Dossiers

    4
    GLOBAL SALES (USD Million)

    U.S. Medicaid

    392.00

    Annual Reports

    0

    FDF Market Place

    0

    EXCIPIENTS
    205
    PATENTS & EXCLUSIVITIES

    USFDA Orange Book Patents

    8

    USFDA Exclusivities

    0

    DIGITAL CONTENT

    Blog #PharmaFlow

    0

    News

    4
    REF STANDARD

    EDQM

    0

    USP

    0

    JP

    0

    Other Listed Suppliers

    0

    SERVICES

    0

    Carvedilol Phosphate
    Also known as: Carvedilol phosphate, 1196658-85-1, Carvedilol (phosphate hemihydrate), 4s19o2f64l, Bm 14190 (phosphate hemihydrate), 2-propanol, 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, phosphate, hydrate (1:1:1)
    Molecular Formula
    C24H31N2O9P
    Molecular Weight
    522.5  g/mol
    InChI Key
    JAYBFQXVKDGMFT-UHFFFAOYSA-N
    FDA UNII
    4S19O2F64L
    Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. The S enantiomer of carvedilol nonselectively binds to and blocks beta-adrenergic receptors, thereby exerting negative inotropic and chronotropic effects, and leading to a reduction in cardiac output. In addition, both enantiomers of carvedilol bind to and block alpha 1-adrenergic receptors, thereby causing vasodilation and reducing peripheral vascular resistance.
    1 2D Structure

    Carvedilol Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;phosphoric acid;hydrate
    2.1.2 InChI
    InChI=1S/C24H26N2O4.H3O4P.H2O/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20;1-5(2,3)4;/h2-12,17,25-27H,13-16H2,1H3;(H3,1,2,3,4);1H2
    2.1.3 InChI Key
    JAYBFQXVKDGMFT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    4S19O2F64L
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Carvedilol Phosphate

    2. 1196658-85-1

    3. Carvedilol (phosphate Hemihydrate)

    4. 4s19o2f64l

    5. Bm 14190 (phosphate Hemihydrate)

    6. 2-propanol, 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, Phosphate, Hydrate (1:1:1)

    7. 2-propanol,1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-,phosphate (salt), Hydrate (2:2:1)

    8. Unii-4s19o2f64l

    9. Schembl599530

    10. 309c892

    11. Q27260413

    12. 1-9h-(carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Phosphate Hemihydrate

    2.4 Create Date
    2008-01-22
    3 Chemical and Physical Properties
    Molecular Weight 522.5 g/mol
    Molecular Formula C24H31N2O9P
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count10
    Exact Mass522.17671757 g/mol
    Monoisotopic Mass522.17671757 g/mol
    Topological Polar Surface Area155 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity557
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCoreg cr
    PubMed HealthCarvedilol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Active IngredientCarvedilol phosphate
    Dosage FormCapsule, extended release
    RouteOral
    Strength10mg; 80mg; 40mg; 20mg
    Market StatusPrescription
    CompanySb Pharmco

    2 of 2  
    Drug NameCoreg cr
    PubMed HealthCarvedilol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Active IngredientCarvedilol phosphate
    Dosage FormCapsule, extended release
    RouteOral
    Strength10mg; 80mg; 40mg; 20mg
    Market StatusPrescription
    CompanySb Pharmco

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Adrenergic beta1-Antagonists [MoA]; Adrenergic beta2-Antagonists [MoA]; alpha-Adrenergic Blocker [EPC]; beta-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]
    left grey arrow
    right gray arrow
    • CAPSULE, EXTENDED RELEASE;ORAL - 10MG
    • CAPSULE, EXTENDED RELEASE;ORAL - 20MG
    • CAPSULE, EXTENDED RELEASE;ORAL - 40MG
    • CAPSULE, EXTENDED RELEASE;ORAL - 80MG
    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty
    euroapi-m-2024-04-29

    Access Virtual Booth

    Contact Supplier

    View Presentation

    Phyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

    Access Virtual Booth

    Contact Supplier

    View Presentation

    Post Enquiry
    POST ENQUIRY

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search