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Chemistry

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Also known as: 2432994-31-3, Kt-474, Kt474, N-[3-(difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1h-benzimidazol-4-yl]-2-propyn-1-yl]oxy]-1-piperidinyl]methyl]cyclohexyl]-1h-pyrazol-4-yl]-5-(1r,4r)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1r,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2sxr65p7e3
Molecular Formula
C44H49F2N11O6
Molecular Weight
865.9  g/mol
InChI Key
NQGKNAVUMAHSQN-PKIOHZLWSA-N
FDA UNII
2SXR65P7E3

KT-474
1 2D Structure

KT-474

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
2.1.2 InChI
InChI=1S/C44H49F2N11O6/c1-52-39-27(4-2-6-34(39)57(44(52)61)35-11-12-37(58)50-43(35)60)5-3-19-62-30-13-16-53(17-14-30)22-26-7-9-28(10-8-26)56-24-33(38(51-56)40(45)46)48-42(59)32-21-47-55-18-15-36(49-41(32)55)54-23-31-20-29(54)25-63-31/h2,4,6,15,18,21,24,26,28-31,35,40H,7-14,16-17,19-20,22-23,25H2,1H3,(H,48,59)(H,50,58,60)/t26?,28?,29-,31-,35?/m1/s1
2.1.3 InChI Key
NQGKNAVUMAHSQN-PKIOHZLWSA-N
2.1.4 Canonical SMILES
CN1C2=C(C=CC=C2N(C1=O)C3CCC(=O)NC3=O)C#CCOC4CCN(CC4)CC5CCC(CC5)N6C=C(C(=N6)C(F)F)NC(=O)C7=C8N=C(C=CN8N=C7)N9CC1CC9CO1
2.1.5 Isomeric SMILES
CN1C2=C(C=CC=C2N(C1=O)C3CCC(=O)NC3=O)C#CCOC4CCN(CC4)CC5CCC(CC5)N6C=C(C(=N6)C(F)F)NC(=O)C7=C8N=C(C=CN8N=C7)N9C[C@H]1C[C@@H]9CO1
2.2 Other Identifiers
2.2.1 UNII
2SXR65P7E3
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2432994-31-3

2. Kt-474

3. Kt474

4. N-[3-(difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1h-benzimidazol-4-yl]-2-propyn-1-yl]oxy]-1-piperidinyl]methyl]cyclohexyl]-1h-pyrazol-4-yl]-5-(1r,4r)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide

5. N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1r,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

6. 2sxr65p7e3

7. Schembl21998241

8. Schembl23807243

9. Schembl25986139

10. Gtpl12892

11. Kym-001

12. Glxc-26797

13. Glxc-27930

14. Ex-a8217

15. Kt-i-417

16. Sar444656

17. At41570

18. Kt-474?

19. Sar-444656

20. Compound A [wo2022174269a1]

21. Da-77150

22. Hy-145483

23. Cs-0374973

24. 5-((1r,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-n-(3-(difluoromethyl)-1-((1r,4r)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

25. Pyrazolo(1,5-a)pyrimidine-3-carboxamide, N-(3-(difluoromethyl)-1-(trans-4-((4-((3-(1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1h-benzimidazol-4-yl)-2-propyn-1-yl)oxy)-1-piperidinyl)methyl)cyclohexyl)-1h-pyrazol-4-yl)-5-(1r,4r)-2-oxa-5-azabicyclo(2.2.1)hept-5-yl-

2.4 Create Date
2020-06-27
3 Chemical and Physical Properties
Molecular Weight 865.9 g/mol
Molecular Formula C44H49F2N11O6
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count13
Rotatable Bond Count11
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area172
Heavy Atom Count63
Formal Charge0
Complexity1790
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2432994-31-3 / KT-474 API manufacturers, exporters & distributors?

KT-474 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of KT-474 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right KT-474 manufacturer or KT-474 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred KT-474 manufacturer or KT-474 supplier.

PharmaCompass also assists you with knowing the KT-474 API Price utilized in the formulation of products. KT-474 API Price is not always fixed or binding as the KT-474 Price is obtained through a variety of data sources. The KT-474 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

KT-474

Synonyms

2432994-31-3, Kt474, N-[3-(difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1h-benzimidazol-4-yl]-2-propyn-1-yl]oxy]-1-piperidinyl]methyl]cyclohexyl]-1h-pyrazol-4-yl]-5-(1r,4r)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1r,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2sxr65p7e3, Schembl21998241

Cas Number

2432994-31-3

Unique Ingredient Identifier (UNII)

2SXR65P7E3

2432994-31-3 Manufacturers

A 2432994-31-3 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 2432994-31-3, including repackagers and relabelers. The FDA regulates 2432994-31-3 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 2432994-31-3 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

2432994-31-3 Suppliers

A 2432994-31-3 supplier is an individual or a company that provides 2432994-31-3 active pharmaceutical ingredient (API) or 2432994-31-3 finished formulations upon request. The 2432994-31-3 suppliers may include 2432994-31-3 API manufacturers, exporters, distributors and traders.

2432994-31-3 GMP

2432994-31-3 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 2432994-31-3 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 2432994-31-3 GMP manufacturer or 2432994-31-3 GMP API supplier for your needs.

2432994-31-3 CoA

A 2432994-31-3 CoA (Certificate of Analysis) is a formal document that attests to 2432994-31-3's compliance with 2432994-31-3 specifications and serves as a tool for batch-level quality control.

2432994-31-3 CoA mostly includes findings from lab analyses of a specific batch. For each 2432994-31-3 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

2432994-31-3 may be tested according to a variety of international standards, such as European Pharmacopoeia (2432994-31-3 EP), 2432994-31-3 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (2432994-31-3 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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