Find Opevesostat manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 2231294-96-3, Odm-208, Odm208, 2-(isoindolin-2-ylmethyl)-5-[[1-(methylsulfonyl)-4-piperidyl]methoxy]-4h-pyran-4-one, 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4h-pyran-4-one, Opevesostat [inn]
Molecular Formula
C21H26N2O5S
Molecular Weight
418.5  g/mol
InChI Key
LHVKCOBGLZGRQZ-UHFFFAOYSA-N
FDA UNII
1Z7MAV4KQC

Opevesostat
Opevesostat is an orally bioavailable, non-steroidal, selective inhibitor of the enzyme cytochrome 450 side-chain cleavage (scc) (CYP11A1), with potential antineoplastic activity. Upon oral administration, opevesostat targets, binds to and inhibits the activity of CYP11A1. This prevents the synthesis of all steroid hormones and their precursors. This may inhibit proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the first rate-liming step in steroid hormone biosynthesis.
1 2D Structure

Opevesostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(1,3-dihydroisoindol-2-ylmethyl)-5-[(1-methylsulfonylpiperidin-4-yl)methoxy]pyran-4-one
2.1.2 InChI
InChI=1S/C21H26N2O5S/c1-29(25,26)23-8-6-16(7-9-23)14-28-21-15-27-19(10-20(21)24)13-22-11-17-4-2-3-5-18(17)12-22/h2-5,10,15-16H,6-9,11-14H2,1H3
2.1.3 InChI Key
LHVKCOBGLZGRQZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)N1CCC(CC1)COC2=COC(=CC2=O)CN3CC4=CC=CC=C4C3
2.2 Other Identifiers
2.2.1 UNII
1Z7MAV4KQC
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2231294-96-3

2. Odm-208

3. Odm208

4. 2-(isoindolin-2-ylmethyl)-5-[[1-(methylsulfonyl)-4-piperidyl]methoxy]-4h-pyran-4-one

5. 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4h-pyran-4-one

6. Opevesostat [inn]

7. 1z7mav4kqc

8. Chembl5314533

9. Schembl20300108

10. Glxc-26017

11. Sy347258

12. Hy-156628

13. Cs-0886557

14. G61380

15. 2-[(1,3-dihydro-2h-isoindol-2-yl)methyl]-5-[[1-(methylsulfonyl)-4-piperidinyl]methoxy]-4h-pyran-4-one

16. 4h-pyran-4-one, 2-[(1,3-dihydro-2h-isoindol-2-yl)methyl]-5-[[1-(methylsulfonyl)-4-piperidinyl]methoxy]-

2.4 Create Date
2018-12-15
3 Chemical and Physical Properties
Molecular Weight 418.5 g/mol
Molecular Formula C21H26N2O5S
XLogP31.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area84.5
Heavy Atom Count29
Formal Charge0
Complexity763
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 2231294-96-3 / Opevesostat API manufacturers, exporters & distributors?

Opevesostat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Opevesostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Opevesostat manufacturer or Opevesostat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Opevesostat manufacturer or Opevesostat supplier.

PharmaCompass also assists you with knowing the Opevesostat API Price utilized in the formulation of products. Opevesostat API Price is not always fixed or binding as the Opevesostat Price is obtained through a variety of data sources. The Opevesostat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Opevesostat

Synonyms

2231294-96-3, Odm-208, Odm208, 2-(isoindolin-2-ylmethyl)-5-[[1-(methylsulfonyl)-4-piperidyl]methoxy]-4h-pyran-4-one, 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4h-pyran-4-one, Opevesostat [inn]

Cas Number

2231294-96-3

Unique Ingredient Identifier (UNII)

1Z7MAV4KQC

About Opevesostat

Opevesostat is an orally bioavailable, non-steroidal, selective inhibitor of the enzyme cytochrome 450 side-chain cleavage (scc) (CYP11A1), with potential antineoplastic activity. Upon oral administration, opevesostat targets, binds to and inhibits the activity of CYP11A1. This prevents the synthesis of all steroid hormones and their precursors. This may inhibit proliferation of hormone-positive tumor cells. CYP11A1, a mitochondrial enzyme, catalyzes the conversion of cholesterol to pregnenolone (Preg), which is the first rate-liming step in steroid hormone biosynthesis.

2231294-96-3 Manufacturers

A 2231294-96-3 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 2231294-96-3, including repackagers and relabelers. The FDA regulates 2231294-96-3 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 2231294-96-3 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

2231294-96-3 Suppliers

A 2231294-96-3 supplier is an individual or a company that provides 2231294-96-3 active pharmaceutical ingredient (API) or 2231294-96-3 finished formulations upon request. The 2231294-96-3 suppliers may include 2231294-96-3 API manufacturers, exporters, distributors and traders.

2231294-96-3 GMP

2231294-96-3 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 2231294-96-3 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 2231294-96-3 GMP manufacturer or 2231294-96-3 GMP API supplier for your needs.

2231294-96-3 CoA

A 2231294-96-3 CoA (Certificate of Analysis) is a formal document that attests to 2231294-96-3's compliance with 2231294-96-3 specifications and serves as a tool for batch-level quality control.

2231294-96-3 CoA mostly includes findings from lab analyses of a specific batch. For each 2231294-96-3 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

2231294-96-3 may be tested according to a variety of international standards, such as European Pharmacopoeia (2231294-96-3 EP), 2231294-96-3 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (2231294-96-3 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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