BeiGene and SpringWorks Present Clinical Data on Lifirafenib, in Combination with Mirdametinib, in Patients with Advanced or Refractory Solid Tumors with MAPK Pathway Aberrations at the American Association for Cancer Research Annual Meeting 2023
SpringWorks and BeiGene Present Clinical Data on Lifirafenib, in combination with Mirdametinib, in Patients with Advanced or Refractory Solid Tumors with MAPK Pathway Aberrations at the American Association for Cancer Research Annual Meeting 2023
SpringWorks Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, today announced that the first patient has been dosed in a Phase 1b study to evaluate the combination of SpringWorks Therapeutics’ investigational MEK inhibitor, PD-0325901, and BeiGene, Ltd.’s (Nasdaq: BGNE; HKEX: 06160) investigational RAF dimer inhibitor, lifirafenib (BGB-283), in patients with advanced or refractory solid tumors.
SpringWorks Therapeutics launched in September 2017 with $103 million and a handful of clinical-stage Pfizer drugs. A year later, the startup has named its first CEO and is unveiling a partnership with BeiGene focusing on a targeted combination therapy for an “undruggable” cancer mutation.