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Find Clinical Drug Pipeline Developments & Deals by Zymeworks
The net proceeds will support Company’s research and development strategy, with investigational new drug application filings for ZW171 and ZW191. ZW171 is a bispecific antibody that is designed to engage two different types of cells, tumor cells and immune cells.
Zymeworks and Daiichi Sankyo entered into the Collaboration Agreement to research, develop and commercialize one bispecific antibody generated through the use of Zymeworks BC’s Azymetric and EFECT platforms.
ZW25 (zanidatamab) is an investigational bispecific antibody, based on Zymeworks' Azymetric™ platform, that simultaneously bind two non-overlapping epitopes of HER2, which encourages antitumor activity in patients. It is being investigated for solid tumors that express HER2.
ZW25 (zanidatamab) is an investigational bispecific antibody, based on Zymeworks' Azymetric™ platform, that can simultaneously bind two non-overlapping epitopes of HER2, known as biparatopic binding.
Zanidatamab (ZW25) as monotherapy produced a confirmed objective response rate (cORR) of 41.3% and median duration of response of 12.9 months in patients with previously treated HER2-amplified and expressing biliary tract cancers (BTC).
Zanidatamab is a novel HER2-targeted bispecific antibody with biparatopic binding and the potential to transform the current standard of care in multiple HER2 expressing cancers.
ZW49 (zanidatamab) is bispecific antibody, based on Zymeworks’ Azymetric™ platform, that can simultaneously bind two non-overlapping epitopes of HER2, known as biparatopic binding.
Jazz to obtain exclusive development and commercialization rights of ZW25 (Zanidatamab) in the U.S., Europe and Japan to expand oncology portfolio. Zanidatamab is HER2-targeted bispecific antibody demonstrated anti-tumor activity in HER2-expressing cancers.
Zanidatamab zovodotin (ZW49), is a novel bispecific HER2 ‑targeted antibody-drug conjugate currently in Phase 1 clinical development and combines the unique design and antibody framework of zanidatamab with Zymeworks’ proprietary ZymeLink™ linker and cytotoxin.
ZW49 (zanidatamab zovodotin) shown to have manageable safety profile with encouraging, single-agent anti-tumor activity in patients with HER2+ cancers.
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