Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ventus Doses First Patient in Phase 2a Trial of VENT-02 in Parkinson’s
Details : VENT-02 is a novel, oral, brain-penetrant inhibitor of NLRP3, being investigated in patients with mild to moderate Parkinson’s disease.
Product Name : VENT-02
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 10, 2025
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ventus Therapeutics Completes Phase 1 Trial of VENT-03, a cGAS Inhibitor
Details : VENT-03 is a first-in-class, orally administered cGAS inhibitor. It is being investigating for the treatment of systemic lupus erythematosus (SLE) and other inflammatory disorders.
Product Name : VENT-03
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 31, 2024
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
eFFECTOR Announces $15 Million Registered Direct Offering Priced At-The-Market
Details : VENT-03 is a first-in-class, orally administered cGAS inhibitor. it is under phase 1 clinical development for the treatment of systemic lupus erythematosus (SLE) and other inflammatory disorders.
Product Name : VENT-03
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 01, 2024
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : VENT-02, a novel, orally administered, brain-penetrant NLRP3 inhibitor, is being investigated in neuroinflammatory diseases, including Parkinson’s, Alzheimer’s, and refractory epilepsy, as well as systemic diseases.
Product Name : VENT-02
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 22, 2023
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Michael J. Fox Foundation for Parkinson’s Research
Deal Size : $0.1 million
Deal Type : Funding
Details : Ventus will use the grant to support the identification and development of a NLRP3 PET tracer derived from its portfolio of selective brain-penetrant NLRP3 inhibitors, including VENT-02.
Product Name : VENT-02
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
April 20, 2023
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Michael J. Fox Foundation for Parkinson’s Research
Deal Size : $0.1 million
Deal Type : Funding
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Study Phase : Preclinical
Sponsor : Novo Nordisk
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : VENT-01, Ventus’ lead drug programme, is a peripherally restricted small molecule inhibitor compound that acts on NLR pyrin domain-containing 3 (NLRP3).
Product Name : VENT-03
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 01, 2023
Lead Product(s) : VENT-03
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Sponsor : Novo Nordisk
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : VENT-01
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Study Phase : IND Enabling
Sponsor : Novo Nordisk
Deal Size : $703.0 million
Deal Type : Licensing Agreement
Details : Under the agreement, Novo Nordisk will receive worldwide rights to develop and commercialize Ventus’ lead NLRP3 inhibitor program VENT-01, for a broad range of diseases, including nonalcoholic steatohepatitis, chronic kidney disease, and other cardiome...
Product Name : VENT-01
Product Type : Other Small Molecule
Upfront Cash : $70.0 million
September 29, 2022
Lead Product(s) : VENT-01
Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)
Highest Development Status : IND Enabling
Sponsor : Novo Nordisk
Deal Size : $703.0 million
Deal Type : Licensing Agreement
Lead Product(s) : VENT-01
Therapeutic Area : Immunology
Study Phase : Preclinical
Sponsor : SoftBank Vision Fund
Deal Size : $140.0 million
Deal Type : Series C Financing
Ventus Therapeutics Closes $140 Million Series C Financing
Details : Proceeds will accelerate the scale-up of ReSOLVETM platform to address targets previously considered undruggable and advance the company’s small molecule pipeline across a broad range of diseases, including VENT-01.
Product Name : VENT-01
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
September 02, 2022
Lead Product(s) : VENT-01
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Sponsor : SoftBank Vision Fund
Deal Size : $140.0 million
Deal Type : Series C Financing
Lead Product(s) : VENT-01
Therapeutic Area : Nephrology
Study Phase : IND Enabling
Sponsor : Novo Nordisk
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : VENT-01, Ventus’ first lead program is a peripherally restricted small molecule inhibitor compound targeting NLRP3 for the treatment of renal cardiovascualr hepatic disease.
Product Name : VENT-01
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 10, 2022
Lead Product(s) : VENT-01
Therapeutic Area : Nephrology
Highest Development Status : IND Enabling
Sponsor : Novo Nordisk
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ventus Therapeutics Presents an Overview of its NLRP3 Inhibitors at Inflammasome Therapeutics Summit
Details : VENT-02 has demonstrated potent inhibition of NLRP3 activity in peripheral blood mononuclear cells and whole blood across species. VENT-02 also showed an excellent CNS-to-plasma exposure ratio in all preclinical species.
Product Name : VENT-02
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 12, 2022
Lead Product(s) : VENT-02
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable