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    [{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Millmount Healthcare","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Nephrology","graph2":"Approved FDF","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Otsuka Pharmaceutical \/ Millmount Healthcare","highestDevelopmentStatusID":"15","companyTruncated":"Otsuka Pharmaceutical \/ Millmount Healthcare"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Immediate-Release Tablet","sponsorNew":"Lupin Ltd \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Lupin Ltd \/ Inapplicable"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Nephrology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Otsuka Pharmaceutical \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Inapplicable"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Nephrology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Otsuka Pharmaceutical \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Inapplicable"},{"orgOrder":0,"company":"Gia Dinh People Hospital","sponsor":"Otsuka Holdings","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Undisclosed","graph3":"Gia Dinh People Hospital","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Gia Dinh People Hospital \/ Otsuka Holdings","highestDevelopmentStatusID":"1","companyTruncated":"Gia Dinh People Hospital \/ Otsuka Holdings"},{"orgOrder":0,"company":"Chinese Pulmonary Vascular Disease Research Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Undisclosed","graph3":"Chinese Pulmonary Vascular Disease Research Group","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Chinese Pulmonary Vascular Disease Research Group \/ Inapplicable","highestDevelopmentStatusID":"1","companyTruncated":"Chinese Pulmonary Vascular Disease Research Group \/ Inapplicable"}]

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                            01

                            Lupin Ltd

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                            Lupin Ltd

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Lupin Receives USFDA Approval for Tolvaptan Tablets

                            Details : Jynarque-Generic (tolvaptan) is a selective vasopressin V2-receptor antagonist indicated to slow kidney function decline in adults at risk of autosomal dominant polycystic kidney disease.

                            Product Name : Jynarque-Generic

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 24, 2025

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Chinese Pulmonary Vascular Disease Research Group

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                            Chinese Pulmonary Vascular Disease Research Group

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAH

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 06, 2022

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Otsuka Pharmaceutical

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                            ChemOutsourcing
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less T...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 08, 2021

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Otsuka Pharmaceutical

                            Japan arrow
                            ChemOutsourcing
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                            Otsuka Pharmaceutical

                            Japan arrow
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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Year...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 04, 2021

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Otsuka Pharmaceutical

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                            ChemOutsourcing
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : Millmount Healthcare

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Samsca®Approved in Japan for Additional Indication of Hyponatremia Due to Syndrome of Inappropriate Antidiure...

                            Details : Oral vasopressin V2-receptor antagonists Samsca® Tablets, Samsca® OD Tablets and SAMSCA® Granules 1% have received regulatory approval in Japan for the indication of hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormone secreti...

                            Product Name : Samsca

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 29, 2020

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : Millmount Healthcare

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Gia Dinh People Hospital

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                            Gia Dinh People Hospital

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Undisclosed

                            Sponsor : Otsuka Holdings

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 02, 2020

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Otsuka Holdings

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Korea Otsuka Pharmaceutical

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                            ChemOutsourcing
                            Not Confirmed

                            Korea Otsuka Pharmaceutical

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluating the Safety and effectivenesS in Adult KorEaN Patients Treated With Tolvaptan for Management of Auto...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 14, 2019

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Assistance Publique – Hôpitaux de Paris

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                            ChemOutsourcing
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                            Assistance Publique – Hôpitaux de Paris

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                            ChemOutsourcing
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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase II

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 30, 2019

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase II

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Brigham and Women's Hospital

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                            ChemOutsourcing
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                            Brigham and Women's Hospital

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            The Role of Vasopressin Antagonism on Renal Sodium Handling

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 10, 2019

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Mario Negri Institute for Pharmacological Research

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                            ChemOutsourcing
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                            Mario Negri Institute for Pharmacological Research

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                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tolvaptan-Octreotide LAR Combination in ADPKD

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 30, 2018

                            Lead Product(s) : Tolvaptan

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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