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    [{"orgOrder":0,"company":"Tolerance Therapeutics","sponsor":"Ligand Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Tolerance Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Tolerance Therapeutics \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Tolerance Therapeutics \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"MacroGenics","sponsor":"Provention Bio","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"MacroGenics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"MacroGenics \/ Provention Bio","highestDevelopmentStatusID":"15","companyTruncated":"MacroGenics \/ Provention Bio"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Hercules Capital","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Financing","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Hercules Capital","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Hercules Capital"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved 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Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention 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Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention 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Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"SVB Leerink","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Public Offering","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ SVB Leerink","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ SVB Leerink"},{"orgOrder":0,"company":"Provention Bio","sponsor":"SVB Leerink","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Public Offering","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ SVB Leerink","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ SVB Leerink"},{"orgOrder":0,"company":"AGC Biologics","sponsor":"Provention Bio","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"AGC Biologics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"AGC Biologics \/ Provention Bio","highestDevelopmentStatusID":"15","companyTruncated":"AGC Biologics \/ Provention Bio"},{"orgOrder":0,"company":"NexImmune","sponsor":"JDRF","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Other Large Molecule","year":"2022","type":"Partnership","leadProduct":"Teplizumab","moa":"||Undisclosed","graph1":"Endocrinology","graph2":"Preclinical","graph3":"NexImmune","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"NexImmune \/ JDRF","highestDevelopmentStatusID":"4","companyTruncated":"NexImmune \/ JDRF"}]

    Find Clinical Drug Pipeline Developments & Deals for Teplizumab

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                            01

                            Provention Bio

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                            Provention Bio

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Sanofi

                            Deal Size : $2,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Sanofi Completes Acquisition of Provention Bio, Inc.

                            Details : Through the acquisition of Provention Bio, Sanofi adds to its portfolio, TZIELD (teplizumab-mzwv), a CD3-directed antibody, the first disease-modifying treatment for the delay of Stage 3 type 1 diabetes (T1D).

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : $2,900.0 million

                            April 27, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Sanofi

                            Deal Size : $2,900.0 million

                            Deal Type : Acquisition

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                            02

                            Provention Bio

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Sanofi

                            Deal Size : $2,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Sanofi To Acquire Provention Bio, Adding To Portfolio Tzield, The First Disease-modifying Treatment For The De...

                            Details : Through the acquisition of Provention Bio, Sanofi adds to its portfolio, TZIELD (teplizumab-mzwv), a CD3-directed antibody, the first disease-modifying treatment for the delay of Stage 3 type 1 diabetes (T1D).

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : $2,900.0 million

                            March 13, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Sanofi

                            Deal Size : $2,900.0 million

                            Deal Type : Acquisition

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                            03

                            Provention Bio

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase II

                            Sponsor : Sanofi

                            Deal Size : $35.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Provention Bio Announces Completion of $35 Million Equity Investment from Sanofi US

                            Details : The financing will be used to support the commercial launch of TZIELD (teplizumab-mzwv). TZIELD is a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and pediatric patients aged 8 years and older with Stage 2 T1D.

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            February 13, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase II

                            Sponsor : Sanofi

                            Deal Size : $35.0 million

                            Deal Type : Agreement

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                            04

                            Provention Bio

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                            Provention Bio

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Provention Bio Announces Closing of Second Tranche with Hercules Capital to Support U.S. Commercial Launch of ...

                            Details : Tzield (teplizumab-mzwv) is a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and pediatric patients aged 8 years and older with Stage 2 T1D.

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            February 02, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Hercules Capital

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            05

                            AGC Biologics

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                            AGC Biologics

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Provention Bio

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            AGC Biologics to Commercial Manufacture Provention Bio Diabetes Therapy

                            Details : Under the agreement, AGC Biologics will manufacture TZIELD™ (teplizumab-mzwv), a new T1D treatment. TZIELD is the first and only immunomodulatory treatment that delays the onset of Stage 3 T1D in adult and pediatric patients aged 8 years and older.

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            January 24, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Provention Bio

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            Tolerance Therapeutics

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                            Tolerance Therapeutics

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Ligand Pharmaceuticals

                            Deal Size : $20.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Ligand Acquires Royalty on Sanofi’s TZIELD® for $20 Million

                            Details : Through the acquisition, Ligand acquires royalty on Sanofi’s Tzield (teplizumab-mzwv), the first disease-modifying therapy in type 1 diabetes and a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and children aged 8 years an...

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : $20.0 million

                            January 11, 2023

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Ligand Pharmaceuticals

                            Deal Size : $20.0 million

                            Deal Type : Acquisition

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                            07

                            MacroGenics

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                            MacroGenics

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Provention Bio

                            Deal Size : $395.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            MacroGenics Earns $60 Million Milestone with U.S. FDA Approval of Teplizumab

                            Details : Under the terms of the agreements held in 2018, Provention has acquired all rights to Tzield (teplizumab) to be further developed as PRV-031 and licensing rights to MGD010 for development as PRV-3279.

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            November 17, 2022

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Provention Bio

                            Deal Size : $395.0 million

                            Deal Type : Agreement

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                            08

                            Provention Bio

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                            Provention Bio

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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Approves First Drug That Can Delay Onset of Type 1 Diabetes

                            Details : Tzield (teplizumab-mzwv) binds to certain immune system cells and delays progression to stage 3 type 1 diabetes. Tzield may deactivate the immune cells that attack insulin-producing cells, while increasing the proportion of cells that help moderate the i...

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            November 17, 2022

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            NexImmune

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                            Lead Product(s) : Undisclosed,Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Preclinical

                            Sponsor : JDRF

                            Deal Size : $0.6 million

                            Deal Type : Partnership

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                            NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

                            Details : The JDRF award will fund efforts to investigate the use of NexImmune’s AIM nanoparticles in combination with a murine surrogate of teplizumab. The investigation will test this hypothesis in a preclinical model by combining anti-CD3 mAb treatment.

                            Product Name : Undisclosed

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            October 05, 2022

                            Lead Product(s) : Undisclosed,Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Preclinical

                            Sponsor : JDRF

                            Deal Size : $0.6 million

                            Deal Type : Partnership

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                            10

                            Provention Bio

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                            Provention Bio

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                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase II

                            Sponsor : Sanofi

                            Deal Size : $55.0 million

                            Deal Type : Agreement

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                            Provention Bio to Combine Forces with Sanofi to Support Potential U.S. Launch of Teplizumab for Delay in Onset...

                            Details : Teplizumab (PRV-031), is an investigational anti-CD3 monoclonal antibody that is being evaluated for the delay of clinical type 1 diabetes (T1D) in at-risk individuals, as indicated by the presence of two or more T1D-related autoantibodies.

                            Product Name : Tzield

                            Product Type : Antibody

                            Upfront Cash : $20.0 million

                            June 10, 2022

                            Lead Product(s) : Teplizumab

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase II

                            Sponsor : Sanofi

                            Deal Size : $55.0 million

                            Deal Type : Agreement

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