[{"orgOrder":0,"company":"Tolerance Therapeutics","sponsor":"Ligand Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Tolerance Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Tolerance Therapeutics \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Tolerance Therapeutics \/ Ligand Pharmaceuticals"},{"orgOrder":0,"company":"MacroGenics","sponsor":"Provention Bio","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"MacroGenics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"MacroGenics \/ Provention Bio","highestDevelopmentStatusID":"15","companyTruncated":"MacroGenics \/ Provention Bio"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Hercules Capital","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Financing","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Hercules Capital","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Hercules Capital"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Acquisition","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Sanofi","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Sanofi"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention 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Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention 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Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention 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Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"SVB Leerink","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Public Offering","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ SVB Leerink","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ SVB Leerink"},{"orgOrder":0,"company":"Provention Bio","sponsor":"SVB Leerink","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Public Offering","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Provention Bio \/ SVB Leerink","highestDevelopmentStatusID":"15","companyTruncated":"Provention Bio \/ SVB Leerink"},{"orgOrder":0,"company":"AGC Biologics","sponsor":"Provention Bio","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Agreement","leadProduct":"Teplizumab","moa":"CD3","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"AGC Biologics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"AGC Biologics \/ Provention Bio","highestDevelopmentStatusID":"15","companyTruncated":"AGC Biologics \/ Provention Bio"},{"orgOrder":0,"company":"NexImmune","sponsor":"JDRF","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Other Large Molecule","year":"2022","type":"Partnership","leadProduct":"Teplizumab","moa":"||Undisclosed","graph1":"Endocrinology","graph2":"Preclinical","graph3":"NexImmune","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"NexImmune \/ JDRF","highestDevelopmentStatusID":"4","companyTruncated":"NexImmune \/ JDRF"}]

Find Clinical Drug Pipeline Developments & Deals for Teplizumab

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                          Top Deals by Deal Size (USD bn)

                          01

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Through the acquisition of Provention Bio, Sanofi adds to its portfolio, TZIELD (teplizumab-mzwv), a CD3-directed antibody, the first disease-modifying treatment for the delay of Stage 3 type 1 diabetes (T1D).

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : $2,900.0 million

                          April 27, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Sanofi

                          Deal Size : $2,900.0 million

                          Deal Type : Acquisition

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                          02

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Through the acquisition of Provention Bio, Sanofi adds to its portfolio, TZIELD (teplizumab-mzwv), a CD3-directed antibody, the first disease-modifying treatment for the delay of Stage 3 type 1 diabetes (T1D).

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : $2,900.0 million

                          March 13, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Sanofi

                          Deal Size : $2,900.0 million

                          Deal Type : Acquisition

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                          03

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : The financing will be used to support the commercial launch of TZIELD (teplizumab-mzwv). TZIELD is a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and pediatric patients aged 8 years and older with Stage 2 T1D.

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          February 13, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $35.0 million

                          Deal Type : Agreement

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                          04

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Tzield (teplizumab-mzwv) is a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and pediatric patients aged 8 years and older with Stage 2 T1D.

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          February 02, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Hercules Capital

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          05

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Under the agreement, AGC Biologics will manufacture TZIELD™ (teplizumab-mzwv), a new T1D treatment. TZIELD is the first and only immunomodulatory treatment that delays the onset of Stage 3 T1D in adult and pediatric patients aged 8 years and older.

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          January 24, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Provention Bio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          Tolerance Therapeutics

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Tolerance Therapeutics

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Through the acquisition, Ligand acquires royalty on Sanofi’s Tzield (teplizumab-mzwv), the first disease-modifying therapy in type 1 diabetes and a CD3-directed antibody indicated to delay the onset of Stage 3 T1D in adults and children aged 8 years an...

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : $20.0 million

                          January 11, 2023

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Ligand Pharmaceuticals

                          Deal Size : $20.0 million

                          Deal Type : Acquisition

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                          07

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Under the terms of the agreements held in 2018, Provention has acquired all rights to Tzield (teplizumab) to be further developed as PRV-031 and licensing rights to MGD010 for development as PRV-3279.

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          November 17, 2022

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Provention Bio

                          Deal Size : $395.0 million

                          Deal Type : Agreement

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                          08

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Tzield (teplizumab-mzwv) binds to certain immune system cells and delays progression to stage 3 type 1 diabetes. Tzield may deactivate the immune cells that attack insulin-producing cells, while increasing the proportion of cells that help moderate the i...

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          November 17, 2022

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : The JDRF award will fund efforts to investigate the use of NexImmune’s AIM nanoparticles in combination with a murine surrogate of teplizumab. The investigation will test this hypothesis in a preclinical model by combining anti-CD3 mAb treatment.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 05, 2022

                          Lead Product(s) : Undisclosed,Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : JDRF

                          Deal Size : $0.6 million

                          Deal Type : Partnership

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                          10

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Provention Bio

                          Country arrow
                          Iran Expo
                          Not Confirmed

                          Details : Teplizumab (PRV-031), is an investigational anti-CD3 monoclonal antibody that is being evaluated for the delay of clinical type 1 diabetes (T1D) in at-risk individuals, as indicated by the presence of two or more T1D-related autoantibodies.

                          Product Name : Tzield

                          Product Type : Antibody

                          Upfront Cash : $20.0 million

                          June 10, 2022

                          Lead Product(s) : Teplizumab

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $55.0 million

                          Deal Type : Agreement

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