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    [{"orgOrder":0,"company":"Syntrix Pharmaceuticals","sponsor":"DF\/Net Research | National Institute on Drug Abuse","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"Desmetramadol","moa":"analgesics (mixed opiate receptor agonists\/antagonists)||Mu opioid receptor","graph1":"Neurology","graph2":"Phase II","graph3":"Syntrix Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Syntrix Pharmaceuticals \/ DF\/Net Research | National Institute on Drug Abuse","highestDevelopmentStatusID":"8","companyTruncated":"Syntrix Pharmaceuticals \/ DF\/Net Research | National Institute on Drug Abuse"},{"orgOrder":0,"company":"Syntrix Pharmaceuticals","sponsor":"National Institute on Drug 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\/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals by Syntrix Pharmaceuticals

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                            01

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of SX-682 Plus Enzalutamide in Men With Abiraterone-Resistant Metastatic Castration Resistant Prostate C...

                            Details : SX-682 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Prostatic Neoplasms, Castration-Resistant.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 29, 2024

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            First-in-Class Investigational SX-682 Demonstrates Single-Agent Efficacy in Patients with Hypomethylating Agen...

                            Details : SX-682 was well tolerated with no maximally tolerated dose and no patient discontinued treatment for adverse events. Treatment-emergent adverse events > grade 3 were most common in the 200 and 400 mg dose cohorts, and those related to neutrophils were co...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 09, 2022

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

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                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Celerion | National Institute on Drug Abuse

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Randomized Study Investigating Oral Desmetramadol Dose Proportionality and Food Effect In Normal Human Subje...

                            Details : Desmetramadol is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Pain.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 24, 2020

                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Celerion | National Institute on Drug Abuse

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Syntrix Completes Initial SX-682 Dosing in Broad Phase 1/2 Cancer Trial Campaign

                            Details : Based on the promising results, additional Phase 1/2 trials are now also opening for SX-682 in pancreatic cancer, colorectal cancer, and in advanced tumors including breast and head & neck cancers at various institutes.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 27, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Study Phase : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Desmetramadol is G-Protein Biased Opioid Receptor Agonist: Syntrix

                            Details : Findings could put desmetramadol in pivotal high-value position for safer opioid prescribing.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 04, 2020

                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Highest Development Status : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Moffitt Cancer Center | National Heart, Lung, and Blood Institute | AdventHealth | Gabrail Cancer Center Research | University of Miami | Mayo Clinic | Montefiore Medical Center | National Cancer Institute | Sidney Kimmel Comprehensive Cancer Center, John

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of SX-682 Alone and in Combination with Oral or Intravenous Decitabine in Subjects with Myelodysplastic ...

                            Details : SX-682 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Myelodysplastic Syndromes.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 28, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Moffitt Cancer Center | National Heart, Lung, and Blood Institute | AdventHealth | Gabrail Cancer Center Research | University of Miami | Mayo Clinic | Montefiore Medical Center | National Cancer Institute | Sidney Kimmel Comprehensive Cancer Center, John

                            Deal Size : Inapplicable

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                            07

                            Syntrix Pharmaceuticals

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                            AusBiotech
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                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Sponsor : DF/Net Research | National Institute on Drug Abuse

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Omnitram Safety and Efficacy in the Treatment of Diabetic Neuropathy

                            Details : Omnitram is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Diabetic Neuropathies.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 11, 2018

                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Sponsor : DF/Net Research | National Institute on Drug Abuse

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : Aminopterin

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : National Institute of Allergy and Infectious Diseases

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Once-Weekly Oral Aminopterin for the Treatment of Subjects With Moderate-To-Severe Psoriasis

                            Details : Aminopterin is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Psoriasis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 13, 2018

                            Lead Product(s) : Aminopterin

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : National Institute of Allergy and Infectious Diseases

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : PRA Health Sciences | DF/Net Research | ITT Research Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Omnitram Pharmacokinetic and Analgesic Study Following CY2D6 Inhibition With Paroxetine In Healthy Volunteers

                            Details : Omnitram is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Pain.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 18, 2017

                            Lead Product(s) : Desmetramadol

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : PRA Health Sciences | DF/Net Research | ITT Research Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Massachusetts General Hospital | National Cancer Institute | Dana-Farber Cancer Institute | Mayo Clinic | University of Rochester | MD Anderson Cancer Center | University of Miami

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab

                            Details : SX-682 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Melanoma.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 19, 2017

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Massachusetts General Hospital | National Cancer Institute | Dana-Farber Cancer Institute | Mayo Clinic | University of Rochester | MD Anderson Cancer Center | University of Miami

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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