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            Toraymyxin (Polymyxin B) is a small molecule drug candidate which is shown to inhibit bacterial respiration. It is being evaluated for the treatment of septic shock.

            Lead Product(s): Polymyxin B Sulfate

            Therapeutic Area: Infections and Infectious Diseases Product Name: Toraymyxin

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 10, 2024

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            Through agreement, Baxter’s exclusive rights to commercialize Toraymyxin (polymyxin B), a therapeutic hemoperfusion device that removes endotoxin, which can cause sepsis, from the bloodstream and is guided by Spectral’s Endotoxin Activity Assay.

            Lead Product(s): Polymyxin B Sulfate

            Therapeutic Area: Infections and Infectious Diseases Product Name: Toraymyxin

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Baxter Healthcare Corporation

            Deal Size: Undisclosed Upfront Cash: $5.0 million

            Deal Type: Agreement February 21, 2024

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            PMX (Toraymyxin™ PMX-20R) is a polymyxin B extracorporeal direct hemoperfusion adsorption column which is highly effective in removing endotoxin which can cause sepsis, from the bloodstream.

            Lead Product(s): Polymyxin B Sulfate

            Therapeutic Area: Infections and Infectious Diseases Product Name: Toraymyxin

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 14, 2023

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            The net proceeds are expected to be primarily used by the Company on its Phase III registration trial (Tigris) for its unique product for the treatment of patients with septic shock, Toraymyxin (polymyxin B), a therapeutic hemoperfusion device that removes endotoxin.

            Lead Product(s): Polymyxin B Sulfate

            Therapeutic Area: Infections and Infectious Diseases Product Name: Toraymyxin

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Paradigm Capital

            Deal Size: $3.7 million Upfront Cash: Undisclosed

            Deal Type: Private Placement August 10, 2023

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            Toraymyxin PMX 20R, is a Polymyxin B extracorporeal direct hemoperfusion adsorption column which is highly effective in removing endotoxin in the bloodstream.

            Lead Product(s): Polymyxin B Sulfate

            Therapeutic Area: Infections and Infectious Diseases Product Name: Toraymyxin PMX 20R

            Highest Development Status: Approved Product Type: Peptide

            Partner/Sponsor/Collaborator: Dialco Medical

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 20, 2022

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