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Pharmaceutical","sponsor":"Martha Sajatovic","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"Aripiprazole","moa":"Dopamine D2 receptor | Serotonin 2a (5-HT2a) receptor | Serotonin 1a (5-HT1a) receptor","graph1":"Psychiatry\/Psychology","graph2":"Approved FDF","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Insert","sponsorNew":"Otsuka Pharmaceutical \/ Martha Sajatovic","highestDevelopmentStatusID":"15","companyTruncated":"Otsuka Pharmaceutical \/ Martha Sajatovic"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Seung-Jung Park","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"JAPAN","productType":"Miscellaneous","year":"2011","type":"Inapplicable","leadProduct":"Cilostazol","moa":"Phosphodiesterase 3A","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Otsuka Pharmaceutical \/ Seung-Jung Park","highestDevelopmentStatusID":"11","companyTruncated":"Otsuka Pharmaceutical \/ Seung-Jung Park"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"YongChan Lee","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"JAPAN","productType":"Miscellaneous","year":"2016","type":"Inapplicable","leadProduct":"Lansoprazole","moa":"Potassium-transporting ATPase","graph1":"Gastroenterology","graph2":"Phase IV","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Otsuka Pharmaceutical \/ YongChan Lee","highestDevelopmentStatusID":"11","companyTruncated":"Otsuka Pharmaceutical \/ YongChan Lee"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Maisel, Alan, M.D.","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"JAPAN","productType":"Miscellaneous","year":"2012","type":"Inapplicable","leadProduct":"Tolvaptan","moa":"Vasopressin V2 receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Otsuka Pharmaceutical \/ Maisel, Alan, M.D.","highestDevelopmentStatusID":"11","companyTruncated":"Otsuka Pharmaceutical \/ Maisel, Alan, M.D."},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"4D Molecular Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2025","type":"Licensing Agreement","leadProduct":"Aflibercept","moa":"Vascular endothelial growth factor A | Placenta growth factor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0.46999999999999997,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0.46999999999999997,"dosageForm":"Injection","sponsorNew":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Ulotaront","moa":"Trace amine-associated receptor 1 | Serotonin 1a (5-HT1a) receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Otsuka Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"JAPAN","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Centanafadine","moa":"Monoamine transporter","graph1":"Undisclosed","graph2":"Phase I","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Capsule, Extended Release","sponsorNew":"Otsuka Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Otsuka Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Sibeprenlimab","moa":"Tumor necrosis factor ligand superfamily member 13","graph1":"Nephrology","graph2":"Approved FDF","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Otsuka Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"Otsuka Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"GENESIS Pharma","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"JAPAN","productType":"Oligonucleotide","year":"2025","type":"Agreement","leadProduct":"Donidalorsen","moa":"KLKB1","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Injection","sponsorNew":"Otsuka Pharmaceutical \/ GENESIS Pharma","highestDevelopmentStatusID":"15","companyTruncated":"Otsuka Pharmaceutical \/ GENESIS Pharma"}]

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                            01

                            Otsuka Pharmaceutical

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                            BIO Partnering at JPM
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                            Lead Product(s) : Donidalorsen

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : GENESIS Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Genesis Pharma Partners Otsuka for Donidalorsen in Central, Eastern Europe

                            Details : The agreement will support the clinical development of Donidalorsen, an oligonucleotide targeting antisense oligonucleotides for Hereditary Angioedema (HAE).

                            Product Name : Dawnzera

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            December 15, 2025

                            Lead Product(s) : Donidalorsen

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : GENESIS Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Centanafadine

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Trial to Characterize Differences in Blood Levels of Different Lots of Centanafadine QD XR and to Understand...

                            Details : Centanafadine is a small molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 28, 2025

                            Lead Product(s) : Centanafadine

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Otsuka Gets FDA Nod for VOYXACT® to Reduce Proteinuria in IgAN Adults at Risk

                            Details : Sibeprenlimab, an unconjugated antibody, targets tumor necrosis factor ligand superfamily member 13 in the treatment of undisclosed Key Focus Area.

                            Product Name : Voyxact

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            November 25, 2025

                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Otsuka Pharmaceutical

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                            BIO Partnering at JPM
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                            Lead Product(s) : Ulotaront

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Long-term Administration Trial of SEP-363856 in Patients With Schizophrenia

                            Details : Ulotaront is a small molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Schizophrenia.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 07, 2025

                            Lead Product(s) : Ulotaront

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Recipient : 4D Molecular Therapeutics

                            Deal Size : $471.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            4DMT Signs License Deal with Otsuka for 4D-150 in Asia-Pacific

                            Details : Through the licensing for Aflibercept, a protein targeting Vascular endothelial growth factor A and Placenta growth factor, the agreement aims to advance treatment for wet AMD.

                            Product Name : 4D-150

                            Product Type : Protein

                            Upfront Cash : $85.0 million

                            October 30, 2025

                            Lead Product(s) : Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Recipient : 4D Molecular Therapeutics

                            Deal Size : $471.0 million

                            Deal Type : Licensing Agreement

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                            06

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Bedaquiline

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Quabodepistat-containing Regimen for the Treatment of Drug-resistant Pulmonary Tuberculosis

                            Details : Bedaquiline is a small molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Tuberculosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 07, 2025

                            Lead Product(s) : Bedaquiline

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 3 Trial of OPA-15406 Foam in Children and Infants With Atopic Dermatitis

                            Details : Difamilast is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Dermatitis, Atopic.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 22, 2025

                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Otsuka Pharmaceutical

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                            BIO Partnering at JPM
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 3 Trial to Demonstrate the Superiority of 1% OPA-15406 Foam to the Vehicle in Adult Patients With Atop...

                            Details : Difamilast is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Dermatitis, Atopic.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 15, 2025

                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Otsuka Pharmaceutical

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                            BIO Partnering at JPM
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : CAN10

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Recipient : Cantargia AB

                            Deal Size : $613.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Cantargia Closes the Acquisition of CAN10 by Otsuka

                            Details : Through the acquisition, Otsuka will be fully responsible for the development and commercialization of CAN10 globally. It is being evaluated for the treatment of Psoriasis.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : $33.0 million

                            September 11, 2025

                            Lead Product(s) : CAN10

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Recipient : Cantargia AB

                            Deal Size : $613.0 million

                            Deal Type : Acquisition

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                            10

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Recipient : Otsuka Holdings

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Safety and Tolerability, and PK of Sibeprenlimab in Chinese Healthy Subject

                            Details : Sibeprenlimab is a Antibody drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of unspecified medical condition.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            August 05, 2025

                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Recipient : Otsuka Holdings

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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