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Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Foam","sponsorNew":"Otsuka Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"Otsuka Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"JAPAN","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Bedaquiline","moa":"ATP synthase","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Otsuka Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Undisclosed"}]

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                            01

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Bedaquiline

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Quabodepistat-containing Regimen for the Treatment of Drug-resistant Pulmonary Tuberculosis

                            Details : Bedaquiline is a small molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Tuberculosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 07, 2025

                            Lead Product(s) : Bedaquiline

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 3 Trial of OPA-15406 Foam in Children and Infants With Atopic Dermatitis

                            Details : Difamilast is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Dermatitis, Atopic.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 22, 2025

                            Lead Product(s) : Difamilast

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            OTS 2025
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                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Jnana Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Evaluate the Safety and Efficacy of JNT-517 in Participants With Phenylketonuria (PKU)

                            Details : JNT-517 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Phenylketonurias.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 14, 2025

                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Jnana Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Otsuka Files BLA for Sibeprenlimab in Immunoglobulin A Nephropathy Treatment

                            Details : VIS649 (sibeprenlimab) is an investigational humanized IgG2 monoclonal antibody that reduces Gd-IgA1 by binding to APRIL. It is being developed for Immunoglobulin A Nephropathy.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            March 31, 2025

                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Lead Product(s) : OPC-131461

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Proof-of-concept Trial for OPC 131461 in Patients Hospitalized for Worsening Heart Failure

                            Details : OPC-131461 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Heart Failure.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            January 28, 2025

                            Lead Product(s) : OPC-131461

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Otsuka Pharmaceutical

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                            Lead Product(s) : OPF-310

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 ...

                            Details : OPF-310 is a drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Diabetes Mellitus, Type 1.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            August 28, 2024

                            Lead Product(s) : OPF-310

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Recipient : Jnana Therapeutics

                            Deal Size : $1,125.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Japan's Otsuka Pharma to pay up to $1.1 bln to acquire Jnana Therapeutics

                            Details : Through the acquisition, Otsuka will leverage Jana pipelines, which include JNT-517 an allosteric small molecule inhibitor of SLC6A19. It is being evaluated for the treatment of phenylketonuria.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $800.0 million

                            August 01, 2024

                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Jnana Therapeutics

                            Deal Size : $1,125.0 million

                            Deal Type : Acquisition

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                            08

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Donidalorsen Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Ionis Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Ionis Expands Licensing Agreement with Otsuka for Donidalorsen in Hereditary Angioedema

                            Details : Ionis entered into a license agreement with Otsuka & obtained exclusive rights across the Asia-Pacific region for IONIS-PKK-LRx (donidalorsen) for treating hereditary angioedema.

                            Product Name : IONIS-PKK-LRx

                            Product Type : Oligonucleotide

                            Upfront Cash : $20.0 million

                            June 18, 2024

                            Lead Product(s) : Donidalorsen Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Ionis Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Lead Product(s) : Aripiprazole

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion

                            Details : Aripiprazole is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Mental Disorders.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 17, 2024

                            Lead Product(s) : Aripiprazole

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Undisclosed

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Otsuka Pharmaceutical

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                            OTS 2025
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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Otsuka and Lundbeck Submit sNDA for FDA Review of Brexpiprazole and Sertraline Combination

                            Details : Rexulti (brexpiprazole) 5-HT2A receptor, is being evaluated in combination with sertraline in late-stage clinical trials with adult patients for the treatment of post-traumatic stress disorder.

                            Product Name : Rexulti

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 09, 2024

                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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