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KINGDOM","productType":"Peptide","productStatus":"New Molecular Entity","date":"September 2020","url1":"","url2":"","graph1":"Peptide","graph2":"Bicycle Therapeutics"},{"orgOrder":0,"company":"Gyroscope Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Gyroscope Therapeutics Granted FDA Fast Track Designation for GT005","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase II","country":"UNITED KINGDOM","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"September 2020","url1":"","url2":"","graph1":"Cell and Gene therapy","graph2":"Gyroscope Therapeutics"},{"orgOrder":0,"company":"Gyroscope Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Gyroscope's First Patient Received Investigational Gene Therapy GT005 Via Orbit Subretinal Delivery System in Ongoing Phase 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            Details:

            OKYO intends to use the net proceeds primarily for clinical development of the Company’s product candidates including, OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor, to treat ocular diseases.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Undisclosed

            Deal Size: $5.8 million Upfront Cash: $5.8 million

            Deal Type: Public Offering October 31, 2023

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            OK-101 is a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor which is developed using a membrane-anchored-peptide (MAP) technology and shown to produce anti-inflammatory and pain-reducing activities in mouse models of dry eye disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 05, 2023

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            OKYO intends to use the net proceeds from the Offering primarily for clinical development of the Company’s product candidates, including OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Undisclosed

            Deal Size: $4.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering September 15, 2023

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            OKYO intends to use the net proceeds from the Offering primarily for clinical development of the Company’s product candidates, including OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Freedom Capital Markets

            Deal Size: $3.9 million Upfront Cash: Undisclosed

            Deal Type: Public Offering September 14, 2023

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            OKYO intends to use the net proceeds from the Offering primarily for clinical development of the Company’s product candidates, including OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Freedom Capital Markets

            Deal Size: $3.9 million Upfront Cash: Undisclosed

            Deal Type: Public Offering September 14, 2023

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            OKYO intends to use the net proceeds from the Offering primarily for clinical development of the Company’s product candidates, including OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Freedom Capital Markets

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering September 13, 2023

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            Details:

            OK-101 is a lipid conjugated chemerin peptide antagonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response to treat dry eye disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 08, 2023

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            Details:

            OK-101 is a lipid conjugated chemerin peptide antagonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response to treat Dry Eye Disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 30, 2023

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            Details:

            OKYO intends to use the net proceeds primarily for clinical development of the Company’s product candidates including, OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor, being developed for dry eye disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: ThinkEquity

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering July 31, 2023

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            Details:

            OKYO intends to use the net proceeds primarily for clinical development of the Company’s product candidates including, OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor, being developed for dry eye disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: ThinkEquity

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering July 28, 2023

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