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Lead Product(s): GEN-001,Avelumab
Therapeutic Area: Oncology Product Name: GEN-001
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Genome & Company
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration March 09, 2021
Details:
The collaboration follows in just a year after signing the first agreement with Merck KGaA, Darmstadt, Germany and Pfizer in December 2019 to conduct the first combination clinical trial of avelumab (BAVENCIO®) and GEN-001.
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Lead Product(s): CV8102
Therapeutic Area: Oncology Product Name: CV8102
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 04, 2021
Details:
CV8102 had shown promising evidence of efficacy after intratumoral application as a single agent, and in combination with systemic anti-PD-1 antibody treatment.
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Lead Product(s): UniCAR-T-PSMA
Therapeutic Area: Oncology Product Name: UniCAR-T-PSMA
Highest Development Status: Phase I Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 03, 2020
Details:
GEMoaB has apheresed the first patient in a Phase IA study with UniCAR-T-PSMA, the lead solid tumor product candidate from its proprietary UniCAR cellular immunotherapy platform.
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Lead Product(s): AFM13,Pembrolizumab
Therapeutic Area: Oncology Product Name: AFM13
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Merck & Co. Inc.
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 19, 2020
Details:
The results demonstrate promising signs of efficacy including an objective response rate of 88% at the highest treatment dose of AFM13 with KEYTRUDA, as well as a complete CR of 46%. As a monotherapy, KEYTRUDA demonstrated an ORR of 69% and a CR of 22.4% in the KEYNOTE-087.
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Lead Product(s): IMA101
Therapeutic Area: Oncology Product Name: IMA101
Highest Development Status: Phase I Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 10, 2020
Details:
ACTolog® demonstrates feasibility of a multi-target multi-T cell product approach. The target positivity rate of 90% demonstrated that such a multi-target approach leads to minimal patient attrition during screening due to lack of target expression.
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Lead Product(s): AFM13-NK cells,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area: Oncology Product Name: AFM13-NK cells
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 09, 2020
Details:
AFM13-preloaded cNK cells from healthy donors exhibited superior responses versus those from Hodgkin lymphoma patients suggesting that the source of NK cells impacts tumor cell killing.
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Lead Product(s): AFM13-NK cells,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area: Oncology Product Name: AFM13-NK cells
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 06, 2020
Details:
First in human study to combine an NK cell product with an antibody whose primary mechanism is designed to specifically bind and activate NK cells and tumors cells in a bispecific fashion.
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Lead Product(s): BI 905711
Therapeutic Area: Oncology Product Name: BI 905711
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 10, 2020
Details:
The first-in-class BI 905711 antibody is designed to recognize both the pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 and the tumor cell anchor CDH17 to activate apoptosis pathway in co-expressing tumor cells found mostly in the GI tract.
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Lead Product(s): IMA202
Therapeutic Area: Oncology Product Name: IMA202
Highest Development Status: Phase I Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 18, 2020
Details:
First patient in the IMA202-101 trial in Europe following the Clinical Trial Application (CTA, the equivalent of an IND approval by FDA) approval by Paul-Ehrlich-Institute (PEI), the regulatory body for cell and gene therapies in Germany.
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Lead Product(s): Tinostamustine
Therapeutic Area: Oncology Product Name: EDO-S101
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