Drugs in Dev.
Oncology
IND Enabling
Germany 
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Lead Product(s) : CVHNLC,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
CureVac Receives FDA IND for mRNA Immunotherapy in Squamous NSCLC
Details : CVHNLC is CureVac's investigational mRNA-based precision immunotherapy consisting of two different mRNA constructs encoding eight tumor-associated antigens with prevalence across sqNSCLC patients.
Product Name : CVHNLC
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
April 07, 2025
Lead Product(s) : CVHNLC,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Medigene Gets FDA Clearance for MDG1015, a TCR-T Therapy for Solid Tumors
Details : MDG1015 is a first-in-class, TCR-T therapy targeting NY-ESO-1/ LAGE-1a. It is being developed for gastric cancer, ovarian cancer, myxoid/round cell liposarcoma and synovial sarcoma.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
September 05, 2024
Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : EIS-12656
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Eisbach Bio Announces FDA Clearance of IND Application for EIS-12656 Allosteric Inhibitor
Details : EIS-12656 targets ALC1 through allosteric mechanisms, suppressing the cancer-relevant genome reorganization induced by DNA damage. This leads to ALC1 chromatin trapping and cancer cell killing.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 06, 2024
Lead Product(s) : EIS-12656
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ATT001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Ariceum Granted UK Authorisation for Phase I Study of Iodine-123 in Glioblastoma
Details : ATT001 is iodine-123 labelled PARP inhibitor, which is currently being evaluated in preclinical studies for the treatment of patients with recurrent glioblastoma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 29, 2024
Lead Product(s) : ATT001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ATT001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Ariceum Files for UK CTA for Iodine-123 PARP Inhibitor in Glioblastoma
Details : ATT001 is iodine-123 labelled PARP inhibitor, which is currently being evaluated in preclinical studies for the treatment of patients with recurrent glioblastoma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 10, 2024
Lead Product(s) : ATT001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : CBE-101
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Cell BioEngines
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the agreement, Miltenyi will develop and manufacture Cell BioEngines' expanded hematopoietic stem cell transplantation (HSCT) product, CBE-101, for clinical use in hematology-oncology.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
December 29, 2023
Lead Product(s) : CBE-101
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Cell BioEngines
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : SY-001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Syena
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Details : Under the agreement, Syena will support the development of a GMP-compliant T-cell receptor (TCR) natural killer (NK) cell therapy, SY-001, targeting the tumor-associated neoantigen, PRAME.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
December 18, 2023
Lead Product(s) : SY-001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Syena
Deal Size : Undisclosed
Deal Type : Licensing Agreement

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Lead Product(s) : VIP943
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Vincerx Pharma Announces FDA Clearance of IND for VIP943
Details : VIP943 is a novel ADC developed using Vincerx’s next-generation ADC technology designed to bind with CD123 and is being investigated in acute myeloid leukemia.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
August 22, 2023
Lead Product(s) : VIP943
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Acimtamig,AB-101
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Artiva Biotherapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : AFM13 is a first-in-class innate cell engager (ICE®) that uniquely leverags the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages to destroy CD30-positive hematologic tumors.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 23, 2023
Lead Product(s) : Acimtamig,AB-101
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Artiva Biotherapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : VIP236
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : VIP236 is a small molecule drug conjugate with an optimized camptothecin payload having a significant activity in patient-derived and metastatic cancer models. It is being developed for treating multiple solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 14, 2023
Lead Product(s) : VIP236
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
