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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Discovery Platform

                            Recipient : ProFound Therapeutics

                            Deal Size : $775.0 million

                            Deal Type : Collaboration

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                            ProFound Therapeutics Announces Multi-Year Strategic Collaboration with Novartis

                            Details : The collaboration of ProFound with Novartis to discover and develop novel therapeutics for cardiovascular disease leveraging its ProFoundry Platform.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : $25.0 million

                            June 26, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Discovery Platform

                            Recipient : ProFound Therapeutics

                            Deal Size : $775.0 million

                            Deal Type : Collaboration

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                            Lead Product(s) : Farabursen

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Recipient : Regulus Therapeutics

                            Deal Size : $1,700.0 million

                            Deal Type : Acquisition

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                            Novartis Completes Acquisition of Regulus Therapeutics

                            Details : Through the acquisition, Novartis will levarage Regulus pipeline, which includes RGLS8429 (farabursen), a potential next-gen oligonucleotide targeting miR-17 for the treatment of ADPKD.

                            Product Name : RGLS8429

                            Product Type : Oligonucleotide

                            Upfront Cash : $800.0 million

                            June 25, 2025

                            Lead Product(s) : Farabursen

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Recipient : Regulus Therapeutics

                            Deal Size : $1,700.0 million

                            Deal Type : Acquisition

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                            03

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis Gets FDA Approval for Vanrafia® to Reduce Proteinuria in IgAN

                            Details : Vanrafia (atrasentan HCl) is an investigational oral endothelin A receptor antagonist (ERA), which is approved for IgAN and early-stage development for other rare kidney diseases.

                            Product Name : Vanrafia

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 02, 2025

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : 177Lu-vipivotide Tetraxetan,68Ga-PSMA-11

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            FDA Approves Novartis' Pluvicto for PSMA+ mCRPC Before Chemotherapy

                            Details : Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a prostate-specific membrane antigen, which is approved for the treatment of PSMA-positive metastatic castration-resistant prostate cancer.

                            Product Name : Pluvicto

                            Product Type : Radiolabelled Compounds

                            Upfront Cash : Inapplicable

                            March 28, 2025

                            Lead Product(s) : 177Lu-vipivotide Tetraxetan,68Ga-PSMA-11

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis’ Fabhalta® FDA Approved for C3 Glomerulopathy (C3G) Treatment

                            Details : Fabhalta (iptacopan) is an oral, Factor B inhibitor of the alternative complement pathway. It is now approved by FDA for the treatment of patients withC3 glomerulopathy.

                            Product Name : Fabhalta

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 20, 2025

                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Onasemnogene Abeparvovec

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis Phase III Data Shows Efficacy of Onasemnogene Abeparvovec in SMA

                            Details : Zolgensma (onasemnogene abeparvovec) is USFDA approved, one time gne therapy that acts as SMN1 gene stimulant. It is indicated for the treatment of spinal muscular atrophy.

                            Product Name : Zolgensma

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 19, 2025

                            Lead Product(s) : Onasemnogene Abeparvovec

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : KRP-M223

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Recipient : KYORIN PHARMACEUTICAL CO LTD

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            KYORIN and Novartis Enter into a Global License Agreement for KRP-M223

                            Details : Under this agreement, KYORIN grants Novartis an exclusive worldwide license to develop, manufacture, and commercialize KRP-M223, an MRGPRX2 antagonist for allergic and inflammatory diseases.

                            Product Name : KRP-M223

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 03, 2025

                            Lead Product(s) : KRP-M223

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Recipient : KYORIN PHARMACEUTICAL CO LTD

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis oral Fabhalta® (iptacopan) Receives Positive CHMP Opinion

                            Details : Fabhalta (iptacopan) is an oral, Factor B inhibitor of the alternative complement pathway. It is being evaluated for the treatment of patients withC3 glomerulopathy.

                            Product Name : Fabhalta

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 28, 2025

                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Onasemnogene Abeparvovec

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis Phase III Study of Onasemnogene Abeparvovec Meets Primary Endpoint in SMA

                            Details : Zolgensma (onasemnogene abeparvovec) is USFDA approved, one time gne therapy that acts as SMN1 gene stimulant. It is indicated for the treatment of spinal muscular atrophy.

                            Product Name : Zolgensma

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 30, 2024

                            Lead Product(s) : Onasemnogene Abeparvovec

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Novartis' Fabhalta® Shows Hemoglobin Improvement in PNH Patients

                            Details : Fabhalta (iptacopan), a factor B inhibitor of the alternative complement pathway 15-17, is evaluated for the treatment of adults with paroxysmal nocturnal hemoglobinuria.

                            Product Name : Fabhalta

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 06, 2024

                            Lead Product(s) : Iptacopan HCl

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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