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Find Novel Neurology Drugs in Preclinical Development in UNITED STATES

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                          01

                          Lead Product(s) : COYA 302,Abatacept

                          Therapeutic Area : Neurology

                          Study Phase : Preclinical

                          Sponsor : Coya Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Details : Under the agreement, Coya will in-license the proposed Abatacept biosimilar for the development of Coya’s combination product for neurodegenerative diseases, COYA 302, an investigational combination biologic for subcutaneous administration, comprised o...

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          March 20, 2023

                          Lead Product(s) : COYA 302,Abatacept

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Coya Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          Lead Product(s) : PKL-021

                          Therapeutic Area : Neurology

                          Study Phase : Preclinical

                          Sponsor : Pikralida biopharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : The partnership involves manufacturing of the drug substance of the clinical candidate PKL-021, needed to support the preclinical research program and the production of an investigational medicinal product for the phase one clinical trial.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 19, 2022

                          Lead Product(s) : PKL-021

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Pikralida biopharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Polpharma CB

                          03

                          Details : The funding will be used to develop an assay platform and novel antibodies to support the treatment, prevention, and early diagnosis of Alzheimer’s disease and other tauopathies.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 10, 2020

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : SBIR

                          Deal Size : Undisclosed

                          Deal Type : Funding

                          Cayman

                          04

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Study Phase : Preclinical

                          Sponsor : Michael J. Fox Foundation for Parkinson’s Research

                          Deal Size : $2.9 million

                          Deal Type : Funding

                          Details : The funding will support the preclinical and translational development of Lysoway’s novel, highly brain-penetrant small molecule TRPML1 agonist.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 05, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Michael J. Fox Foundation for Parkinson’s Research

                          Deal Size : $2.9 million

                          Deal Type : Funding

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                          05

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Through the collaboration, City will leverage its next-generation RNAi engineering technologies to develop an RNAi trigger molecule combined with proprietary drug delivery technology from Biogen.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $16.0 million

                          May 27, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Biogen

                          Deal Size : $1,046.0 million

                          Deal Type : Collaboration

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                          06

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Intranasal Benzodiazepines (BZDs) is being developed by Polyrizon as a first-line treatment for acute repetitive seizures (ARS) and status epilepticus, using its proprietary drug delivery platform.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          May 13, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : A preclinical study has been initiated for intranasal Benzodiazepines (BZDs), as a first-line treatment for acute repetitive seizures (ARS) and status epilepticus.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          March 25, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : The funding aims to support the MRO-002 is an orally bioavailable, brain-penetrant, small molecule antagonist of GPR17. It is being evaluated for progressive multiple sclerosis.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 13, 2025

                          Lead Product(s) : MRO-002

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : National Multiple Sclerosis Society

                          Deal Size : $0.8 million

                          Deal Type : Funding

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                          09

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : The investment will support development of the Company’s growing pipeline of potent, CNS penetrant therapeutics based on its aggregate-selective degrader molecules known as TRIMTACs.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          March 05, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Cambridge Innovation Capital

                          Deal Size : $31.0 million

                          Deal Type : Financing

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                          10

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : DPX-101 is an investigational positive allosteric modulator that selectively targets the α5 subunit of the GABA-A receptor to enhance its function in neurological diseases like alzheimer.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 04, 2025

                          Lead Product(s) : DPX-101

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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