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Health","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institute on Drug Abuse","sponsor":"Altasciences Company Inc | Technical Resources International, Inc. (TRI)","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"MITRAGYNINE","moa":"Mu opioid receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase I","graph3":"National Institute on Drug Abuse","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institute on Drug Abuse \/ Altasciences Company Inc | Technical Resources International, Inc. (TRI)","highestDevelopmentStatusID":"6","companyTruncated":"National Institute on Drug Abuse \/ Altasciences Company Inc | Technical Resources International, Inc. (TRI)"},{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"L9LS","moa":"Circumsporozoite protein (malaria)","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"National Institute of Allergy and Infectious Diseases","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institute of Allergy and Infectious Diseases \/ National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo","highestDevelopmentStatusID":"8","companyTruncated":"National Institute of Allergy and Infectious Diseases \/ National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo"},{"orgOrder":0,"company":"National Institute on Drug Abuse","sponsor":"Anebulo Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Controlled Substance","year":"2025","type":"Inapplicable","leadProduct":"Selonabant","moa":"CNR1","graph1":"Genetic Disease","graph2":"Phase I","graph3":"National Institute on Drug Abuse","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"National Institute on Drug Abuse \/ National Institute on Drug Abuse","highestDevelopmentStatusID":"6","companyTruncated":"National Institute on Drug Abuse \/ National Institute on Drug Abuse"}]

Find Clinical Drug Pipeline Developments & Deals by National Institutes of Health

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Lead Product(s) : L9LS

                          Therapeutic Area : Infections and Infectious Diseases

                          Study Phase : Phase II

                          Sponsor : National Institutes of Health | Malaria Research and Training Center | Faculté de Médecine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : L9LS is currently being evaluated in Phase II clinical studies for the treatment of Malaria.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          October 06, 2025

                          Lead Product(s) : L9LS

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : National Institutes of Health | Malaria Research and Training Center | Faculté de Médecine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The funding will support the development of AD04 (aluminim hydroxide), a small molecule for Alzheimer's disease.

                          Product Name : AD04

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 26, 2025

                          Lead Product(s) : Aluminium Hydroxide

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Recipient : ADvantage Therapeutics

                          Deal Size : $2.5 million

                          Deal Type : Funding

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The Funding aims to advance the ateganosine targeting TERT for advanced non-small cell lung cancer (NSCLC).

                          Product Name : THIO

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 24, 2025

                          Lead Product(s) : Ateganosine,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : MAIA Biotechnology

                          Deal Size : $2.3 million

                          Deal Type : Funding

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                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Belzutifan is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Carcinoma, Renal Cell.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 18, 2025

                          Lead Product(s) : Belzutifan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : NYU Langone Health

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The funding will support the development of a novel platform that combines artificial intelligence and in vivo zebrafish screening to accelerate drug discovery for Alcohol Use Disorder (AUD)

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 11, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Discovery Platform

                          Recipient : Renovaro Biosciences

                          Deal Size : $1.8 million

                          Deal Type : Funding

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The proceeds will support development of its innovative TNF-alpha inhibitor NN-840 program for Alzheimer’s disease and other neurodegenerative conditions.

                          Product Name : NN-840

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          September 10, 2025

                          Lead Product(s) : NN-840

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Recipient : NanoNewron

                          Deal Size : $2.5 million

                          Deal Type : Funding

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : R21 is a Vaccine drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Malaria.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          August 29, 2025

                          Lead Product(s) : R21

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : Serum Institute of India

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Lead Product(s) : Glecaprevir

                          Therapeutic Area : Infections and Infectious Diseases

                          Study Phase : Phase I/ Phase II

                          Sponsor : Gansu Provincial Maternal and Child Health Care Hospital | National Institute of Mental Health | AbbVie Inc

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Glecaprevir is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I/ Phase II clinical studies for the treatment of Hepatitis C.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          June 27, 2025

                          Lead Product(s) : Glecaprevir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Gansu Provincial Maternal and Child Health Care Hospital | National Institute of Mental Health | AbbVie Inc

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Tezepelumab is a Antibody drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Peanut Hypersensitivity.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          June 11, 2025

                          Lead Product(s) : Tezepelumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Immune Tolerance Network | PPD | Rho, Inc

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : AVR-48 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 26, 2025

                          Lead Product(s) : AVR-48

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Recipient : AyuVis Research

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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