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Health","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institutes of Health \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"National Institutes of Health \/ National Institutes of Health"},{"orgOrder":0,"company":"National Institute on Drug Abuse","sponsor":"Altasciences Company Inc | Technical Resources International, Inc. (TRI)","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"MITRAGYNINE","moa":"Mu opioid receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase I","graph3":"National Institute on Drug Abuse","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institute on Drug Abuse \/ Altasciences Company Inc | Technical Resources International, Inc. (TRI)","highestDevelopmentStatusID":"6","companyTruncated":"National Institute on Drug Abuse \/ Altasciences Company Inc | Technical Resources International, Inc. (TRI)"},{"orgOrder":0,"company":"National Institute of Allergy and Infectious Diseases","sponsor":"National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"L9LS","moa":"Circumsporozoite protein (malaria)","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"National Institute of Allergy and Infectious Diseases","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"National Institute of Allergy and Infectious Diseases \/ National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo","highestDevelopmentStatusID":"8","companyTruncated":"National Institute of Allergy and Infectious Diseases \/ National Institutes of Health | Malaria Research and Training Center | Facult\u00e9 de M\u00e9decine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo"},{"orgOrder":0,"company":"National Institute on Drug Abuse","sponsor":"Anebulo Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Controlled Substance","year":"2025","type":"Inapplicable","leadProduct":"Selonabant","moa":"CNR1","graph1":"Genetic Disease","graph2":"Phase I","graph3":"National Institute on Drug Abuse","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"National Institute on Drug Abuse \/ National Institute on Drug Abuse","highestDevelopmentStatusID":"6","companyTruncated":"National Institute on Drug Abuse \/ National Institute on Drug Abuse"}]

    Find Clinical Drug Pipeline Developments & Deals by National Institutes of Health

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                            01

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : L9LS

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : National Institutes of Health | Malaria Research and Training Center | Faculté de Médecine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            L9LS-R21 Interaction

                            Details : L9LS is currently being evaluated in Phase II clinical studies for the treatment of Malaria.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            October 06, 2025

                            Lead Product(s) : L9LS

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : National Institutes of Health | Malaria Research and Training Center | Faculté de Médecine Pharmacie d'Odontostomatologie (FMOS) | University of Sciences, Techniques, and Technologies of Bamako (USTTB) | University of Washington | Indiana University Schoo

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            National Institute on Aging

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institute on Aging

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Aluminium Hydroxide

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Recipient : ADvantage Therapeutics

                            Deal Size : $2.5 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Advantage Therapeutics Receives $2.5M NIH Grant for Alzheimer’s Drug AD04® Development

                            Details : The funding will support the development of AD04 (aluminim hydroxide), a small molecule for Alzheimer's disease.

                            Product Name : AD04

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            September 26, 2025

                            Lead Product(s) : Aluminium Hydroxide

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Recipient : ADvantage Therapeutics

                            Deal Size : $2.5 million

                            Deal Type : Funding

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                            03

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institutes of Health

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Ateganosine,Cemiplimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : MAIA Biotechnology

                            Deal Size : $2.3 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Maia Biotechnology Receives $2.3M NIH Grant for THIO-101 Cancer Trial

                            Details : The Funding aims to advance the ateganosine targeting TERT for advanced non-small cell lung cancer (NSCLC).

                            Product Name : THIO

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            September 24, 2025

                            Lead Product(s) : Ateganosine,Cemiplimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : MAIA Biotechnology

                            Deal Size : $2.3 million

                            Deal Type : Funding

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                            04

                            National Cancer Institute

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Cancer Institute

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Belzutifan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : NYU Langone Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)

                            Details : Belzutifan is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Carcinoma, Renal Cell.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 18, 2025

                            Lead Product(s) : Belzutifan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : NYU Langone Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Discovery Platform

                            Recipient : Renovaro Biosciences

                            Deal Size : $1.8 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Lunai Bioworks Awarded NIH STTR Grant to Develop AI-Powered Platform for AUD Therapeutics

                            Details : The funding will support the development of a novel platform that combines artificial intelligence and in vivo zebrafish screening to accelerate drug discovery for Alcohol Use Disorder (AUD)

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            September 11, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Discovery Platform

                            Recipient : Renovaro Biosciences

                            Deal Size : $1.8 million

                            Deal Type : Funding

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                            06

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : NN-840

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : NanoNewron

                            Deal Size : $2.5 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            NanoNewron Awarded $2.5 Million in NIH STTR Phase 2 Grant to Advance NN-840

                            Details : The proceeds will support development of its innovative TNF-alpha inhibitor NN-840 program for Alzheimer’s disease and other neurodegenerative conditions.

                            Product Name : NN-840

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            September 10, 2025

                            Lead Product(s) : NN-840

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : NanoNewron

                            Deal Size : $2.5 million

                            Deal Type : Funding

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                            07

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : R21

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Recipient : Serum Institute of India

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pfs230D1 + R21 in Matrix-M1 in African School Children and Adults

                            Details : R21 is a Vaccine drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Malaria.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            August 29, 2025

                            Lead Product(s) : R21

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Recipient : Serum Institute of India

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Glecaprevir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Gansu Provincial Maternal and Child Health Care Hospital | National Institute of Mental Health | AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Glecaprevir/Pibrentasvir PK and Safety In Pregnant Women with HCV ± HIV

                            Details : Glecaprevir is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I/ Phase II clinical studies for the treatment of Hepatitis C.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 27, 2025

                            Lead Product(s) : Glecaprevir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Gansu Provincial Maternal and Child Health Care Hospital | National Institute of Mental Health | AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institute of Allergy and Infectious Diseases

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Immune Tolerance Network | PPD | Rho, Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy of Tezepelumab in Peanut Oral Immunotherapy

                            Details : Tezepelumab is a Antibody drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Peanut Hypersensitivity.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            June 11, 2025

                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Immune Tolerance Network | PPD | Rho, Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            National Institutes of Health

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : AVR-48

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Recipient : AyuVis Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Single Ascending Dose and Multiple Ascending Dose Study of AVR-48

                            Details : AVR-48 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 26, 2025

                            Lead Product(s) : AVR-48

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Recipient : AyuVis Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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