Details : OUTREACH-2 study evaluating MTL-CEBPA specifically up-regulates CCAAT/enhancer-binding protein alpha (C/EBP-α) in combination with sorafenib, in comparison to sorafenib alone, in up to 150 patients.
Product Name : MTL-CEBPA
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
January 25, 2022
Lead Product(s) : MTL-CEBPA,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MTL-CEBPA is the first candidate from MiNA’s pipeline of small activating RNA therapeutics. In pre-clinical studies, MTL-CEBPA was shown to counteract a key cancer immune evasion pathway by inhibiting immune suppression by myeloid cells.
Product Name : MTL-CEBPA
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
September 04, 2021
Lead Product(s) : MTL-CEBPA,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Observed clinical activity, including durable and complete tumour responses, suggests that MTL-CEBPA may increase the effectiveness of sorafenib standard of care.
Product Name : MTL-CEBPA
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 29, 2020
Lead Product(s) : MTL-CEBPA,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
MiNA Therapeutics Announces Initiation of Phase I Clinical Study of MTL-CEBPA
Details : The study is designed to assess the safety, tolerability, pharmacology and clinical activity of MTL-CEBPA in combination with pembrolizumab in these patients.
Product Name : MTL-CEBPA
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 03, 2020
Lead Product(s) : MTL-CEBPA,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable