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    [{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"||CD155","graph1":"Oncology","graph2":"Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intralesional Injection","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Istari Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2022","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"||CD155","graph1":"Oncology","graph2":"Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intralesional Injection","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Istari Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"CD155","graph1":"Oncology","graph2":"Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intralesional Injection","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Istari Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"CD155","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravesical Liquid, Instillation","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Istari Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"PD-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Istari Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Istari Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Inapplicable","leadProduct":"Lerapolturev","moa":"PD-1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Istari Oncology","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Istari Oncology \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Istari Oncology \/ Inapplicable"}]

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                            01

                            Istari Oncology

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                            Istari Oncology

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                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Istari Oncology Announces First Patient Dosed in the Non-Muscle-Invasive Bladder Cancer (NMIBC) Substudy of th...

                            Details : PVSRIPO (lerapolturev) is an immunotherapy based on the live attenuated Sabin type 1 polio vaccine, has a distinct target (the poliovirus receptor CD155), which is widely expressed in neoplastic cells of most solid tumors by targeting CD155 it causes tum...

                            Product Name : PVSRIPO

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            January 31, 2023

                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Istari Oncology

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                            IMCAS Asia
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                            Istari Oncology

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                            IMCAS Asia
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                            Lead Product(s) : Lerapolturev,Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Istari Oncology Announces Presentation of Clinical Responses from LUMINOS- 102, an ongoing Phase 2 Trial of Le...

                            Details : PVSRIPO (lerapolturev) is an investigational immunotherapy based on live attenuated Sabin type 1 polio vaccine genetically modified for safety. Lerapolturev has distinct target (the poliovirus receptor CD155), which is widely expressed in neoplastic cell...

                            Product Name : PVSRIPO

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            October 18, 2022

                            Lead Product(s) : Lerapolturev,Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Istari Oncology

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                            Istari Oncology

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                            Not Confirmed
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                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            First Patient Dosed With PVSRIPO in Istari Oncology’s LUMINOS-103 Phase 1/2 Bladder Cancer Sub-Study

                            Details : The phase 2 LUMINOS-103 bladder cancer sub-study will be conducted at approximately 10 research sites across the U.S. It will evaluate both a neoadjuvant approach in patients with resectable disease, and separately in a cohort of patients with metastatic...

                            Product Name : Pvsripo

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            December 10, 2021

                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Istari Oncology

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                            Istari Oncology

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                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Istari Oncology Presents Data on Its PVSRIPO Immunotherapy at the Annual November Meetings for the Society for...

                            Details : PVSRIPO has been shown to activate a patient’s innate and adaptive immune system to facilitate a systemic anti-tumor immune response. PVSRIPO utilizes CD155 (the poliovirus receptor) to enter both solid tumor cells and antigen–presenting cells in the...

                            Product Name : Pvsripo

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            September 11, 2021

                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Istari Oncology

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                            IMCAS Asia
                            Not Confirmed

                            Istari Oncology

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                            IMCAS Asia
                            Not Confirmed
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                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Istari Oncology Announces First Patient Dosed in the LUMINOS-102 Phase 2 Clinical Trial of PVSRIPO

                            Details : The open-label multi-centre, randomised trial will assess the safety, tolerability and initial efficacy of PVSRIPO intratumoral injection alone (Arm 1) and in combination with a PD-1 inhibitor (Arm 2).

                            Product Name : Pvsripo

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            March 31, 2021

                            Lead Product(s) : Lerapolturev

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Istari Oncology

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                            Istari Oncology

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                            IMCAS Asia
                            Not Confirmed
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                            Lead Product(s) : Lerapolturev,Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Istari Oncology Presents Data from Phase 1 Study of PVSRIPO in Patients with Unresectable Treatment Refractory...

                            Details : Data suggest that PVSRIPO, either alone or in combination with anti-PD-1, holds promise for patients with anti-PD-1 refractory melanoma.

                            Product Name : PVSRIPO

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            September 11, 2020

                            Lead Product(s) : Lerapolturev,Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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